Gene Page:SLC17A6

概括?
基因 57084
Symbol SLC17A6
Synonyms dnpi | vglut2
Description solute carrier family 17 member 6
Reference MIM:607563|HGNC:HGNC:16703|Ensembl:ENSG00000091664|HPRD:10459|Vega:OTTHUMG00000166063
Gene type protein-coding
Map location 11p14.3
Pascal p-value 0.203
Fetal beta -0.312
eGene Cerebellar Hemisphere
Myers' cis & trans
Support METABOTROPIC GLUTAMATE RECEPTOR
NEUROTRANSMITTER METABOLISM

数据源中的基因
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关关键字的命中：4

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9875049 chr3 56457469 SLC17A6 57084 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005313 L-glutamate transmembrane transporter activity IEA glutamate (GO term level: 9) -
GO:0005215 transporter activity IEA -
GO:0015293 分类者活动 IEA -
GO：0031402 sodium ion binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0001504 neurotransmitter uptake IEA neuron, Cholinergic, Synap, Neurotransmitter, Glial (GO term level: 8) -
GO:0006814 sodium ion transport IEA -
GO:0006811 ion transport IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0008021 synaptic vesicle IEA Synap, Neurotransmitter (GO term level: 12) -
GO:0019717 synaptosome IEA Synap, Brain (GO term level: 7) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
去：0016020 membrane IEA -
GO：0016021 integral to membrane IEA -
GO:0030054 cell junction IEA -
GO:0031410 cytoplasmic vesicle IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 该途径中的所有SZGR 2.0基因
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241 157 该途径中的所有SZGR 2.0基因
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 94 65 该途径中的所有SZGR 2.0基因
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 49 36 该途径中的所有SZGR 2.0基因
LEE NEURAL CREST STEM CELL UP 146 99 该途径中的所有SZGR 2.0基因
ROVERSI GLIOMA LOH REGIONS 44 30 该途径中的所有SZGR 2.0基因
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164 111 该途径中的所有SZGR 2.0基因
HATADA METHYLATED IN LUNG CANCER UP 390 236 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
LEIN MIDBRAIN MARKERS 82 55 该途径中的所有SZGR 2.0基因
LEIN PONS MARKERS 89 59 该途径中的所有SZGR 2.0基因
LEIN MEDULLA MARKERS 81 48 该途径中的所有SZGR 2.0基因
MARSON BOUND BY FOXP3 STIMULATED 1022 619 该途径中的所有SZGR 2.0基因
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 该途径中的所有SZGR 2.0基因
MARSON FOXP3 TARGETS STIMULATED UP 29 19 该途径中的所有SZGR 2.0基因
KONDO PROSTATE CANCER WITH H3K27ME3 196 93 该途径中的所有SZGR 2.0基因
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-129-5p 746 753 1A,m8 hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
mir-137 1314 1321 1A,m8 hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-141/200a 1725 1731 1A hsa-miR-141 uaacacugucugugugugugaugg
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
hsa-miR-141 uaacacugucugugugugugaugg
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-19 53 59 1A hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-203.1 696 703 1A,m8 hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-25/32/92/363/367 889 895 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 Aauugcacuuuagcaaugga
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 Aauugcacuuuagcaaugga
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-33 887 893 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-330 1636 1642 m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-380-5p 98 104 1A HSA-MIR-380-5p UGGUUGACCAUAGAACAUGCGC
hsa-miR-563 AGGUUGACAUACGUUUCCC
miR-382 789 795 m8 hsa-miR-382brain GAAGUUGUUCGUGGUGGAUUCG
miR-450 746 752 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA