Gene Page:PSMD4
Summary？
| 基因 | 5710 |
| 象征 | PSMD4 |
| Synonyms | AF|AF-1|ASF|MCB1|Rpn10|S5A|pUB-R5 |
| Description | 蛋白酶体26S亚基，非ATPase 4 |
| Reference | MIM：601648|HGNC：HGNC：9561|Ensembl:ENSG00000159352|HPRD：03386|Vega：Otthumg0000000012349 |
| 基因类型 | 蛋白质编码 |
| Map location | 1q21.3 |
| Sherlock p-value | 0.003 |
| 胎儿β | 0.629 |
| 主持人 | 尾状基底神经节 海马 |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:PGCnp | 全基因组协会研究 | GWAS | |
| GSMA_I | Genome scan meta-analysis | PSR：0.0235 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | PSR：0.00814 |
Section I. Genetics and epigenetics annotation
第二节。转录组注释
一般基因表达（GTEX）
Devlopment期间的基因表达（BrainCloud）
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| 前10个积极共表达的基因 | ||
| Gene | 皮尔逊的相关性 | 斯皮尔曼的相关性 |
| MAS1 | 0.74 | 0.66 |
| Ankrd29 | 0.72 | 0.63 |
| BTBD3 | 0.72 | 0.71 |
| Wasl | 0.69 | 0.65 |
| AC110760.2 | 0.69 | 0.67 |
| SORT1 | 0.69 | 0.67 |
| DGKG | 0.68 | 0.67 |
| PLEKHA2 | 0.67 | 0.64 |
| RNF128 | 0.67 | 0.70 |
| SLC45A4 | 0.67 | 0.59 |
| 前10个负共表达基因 | ||
| Gene | 皮尔逊的相关性 | 斯皮尔曼的相关性 |
| BCL7C | -0.36 | -0.49 |
| SH3BP2 | -0.32 | -0.40 |
| SH2B2 | -0.31 | -0.40 |
| KIAA1949 | -0.31 | -0.24 |
| tubb2b | -0.30 | -0.36 |
| GTF3C6 | -0.30 | -0.33 |
| FADS2 | -0.29 | -0.26 |
| SNHG12 | -0.29 | -0.40 |
| PPP1R14B | -0.29 | -0.43 |
| C9orf46 | -0.29 | -0.37 |
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0005515 | 蛋白质结合 | IPI | 17353931|17662948|17891176 |
|
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO：0031145 | 后期促进复合依赖性蛋白酶体依赖性蛋白质分解代谢过程 | 经验 | 11285280 | |
| GO：0051436 | 在有丝分裂细胞周期期间泛素 - 蛋白连接酶活性的负调控 | 经验 | 15029244 | |
| GO：0051437 | positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle | 经验 | 12791267 | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO：0000502 | proteasome complex | TAS | 8811196 | |
| GO:0005829 | 细胞质 | IEA | - |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| ID1 | id |BHLHB24 | DNA结合1的抑制剂，显性负螺旋 - 环螺旋蛋白 | 体外 体内 Two-hybrid |
Biogrid | 9235903 |
| MYOD1 | myf3 |Myod |PUM |BHLHC1 | myogenic differentiation 1 | - | HPRD,BioGRID | 9235903 |
| nedd8 | FLJ43224 |MGC104393 |MGC125896 |MGC125897 |NEDD-8 | 神经前体细胞表达，发育下调8 | - | HPRD,BioGRID | 11585840 |
| NUB1 | BS4 |nub1l |NYREN18 | negative regulator of ubiquitin-like proteins 1 | - | HPRD,BioGRID | 11585840 |
| PSMD10 | dJ889N15.2 | p28 | 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，10 | Affinity Capture-MS | Biogrid | 17353931 |
| PSMD13 | HSPC027 |rpn9 |S11 |P40.5 | 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，13 | Affinity Capture-MS | Biogrid | 17353931 |
| PSMD6 | KIAA0107 | Rpn7 | S10 | SGA-113M | p44S10 | 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，6 | Affinity Capture-MS | Biogrid | 17353931 |
| rad23a | HHR23A |MGC111083 | RAD23同源物A（S. cerevisiae） | - | HPRD | 10488153|11827521 | 12970176 |
| rad23a | HHR23A |MGC111083 | RAD23同源物A（S. cerevisiae） | 重构的复合物 Two-hybrid |
Biogrid | 10488153|12970176 |
| rad23b | HHR23B | HR23B | P58 | RAD23同源物B（S. cerevisiae） | - | HPRD,BioGRID | 10488153|11827521 |
| RASSF8 | C12orf2 |HOJ-1 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | Two-hybrid | Biogrid | 16189514 |
| TCF3 | E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21 | 转录因子3（E2A免疫球蛋白增强子结合因子E12/E47） | - | HPRD,BioGRID | 9235903 |
| traf6 | MGC:3310 | RNF85 | TNF receptor-associated factor 6 | - | HPRD | 14743216 |
| UBQLN2 | Chap1 |Chap1/dsk2 |DSK2 |HRIHFB2157 |LIC-2 |N4BP4 |PLIC-2 |plic2 |RIHFB2157 | ubiquilin 2 | - | HPRD | 11827521 |
Section V. Pathway annotation
| 路径名 | 路径大小 | # SZGR 2.0 genes in pathway | 信息 |
|---|---|---|---|
| kegg蛋白酶体 | 48 | 28 | All SZGR 2.0 genes in this pathway |
| REACTOME信号通过WNT | 65 | 41 | All SZGR 2.0 genes in this pathway |
| 可溶性外源抗原内体的反应组交叉表现 | 48 | 29 | All SZGR 2.0 genes in this pathway |
| Reactome抗原加工交叉呈现 | 76 | 48 | All SZGR 2.0 genes in this pathway |
| REACTOME ER PHAGOSOME PATHWAY | 61 | 40 | All SZGR 2.0 genes in this pathway |
| 反应组细胞周期 | 421 | 253 | All SZGR 2.0 genes in this pathway |
| Reactome ORC1从染色质中去除 | 67 | 37 | All SZGR 2.0 genes in this pathway |
| B细胞受体BCR的Reactome下游信号传导事件 | 97 | 66 | All SZGR 2.0 genes in this pathway |
| B细胞中NF Kappab的反应组激活 | 64 | 43 | All SZGR 2.0 genes in this pathway |
| REACTOME信号通过THE B CELL RECEPTOR BCR | 126 | 90 | All SZGR 2.0 genes in this pathway |
| Reactome P53独立G1 S DNA损伤检查点 | 51 | 31 | All SZGR 2.0 genes in this pathway |
| 反应组CDK介导的磷酸化和CDC6的去除 | 48 | 27 | All SZGR 2.0 genes in this pathway |
| 氨基酸和衍生物的反应组代谢 | 200 | 136 | All SZGR 2.0 genes in this pathway |
| 鸟氨酸脱羧酶ODC的反应组调节 | 49 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF APOPTOSIS | 58 | 34 | All SZGR 2.0 genes in this pathway |
| Reactome细胞周期有丝分裂 | 325 | 185 | All SZGR 2.0 genes in this pathway |
| Reactome细胞周期检查点 | 124 | 70 | All SZGR 2.0 genes in this pathway |
| REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | 65 | 40 | All SZGR 2.0 genes in this pathway |
| Reactome P53依赖G1 DNA损伤响应 | 57 | 35 | All SZGR 2.0 genes in this pathway |
| Reactome M G1过渡 | 81 | 45 | All SZGR 2.0 genes in this pathway |
| Reactome G1 S过渡 | 112 | 63 | All SZGR 2.0 genes in this pathway |
| REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | 56 | 31 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS OF DNA | 92 | 53 | All SZGR 2.0 genes in this pathway |
| REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | 51 | 30 | All SZGR 2.0 genes in this pathway |
| mRNA的反应组代谢 | 284 | 128 | All SZGR 2.0 genes in this pathway |
| READEM RNA的代谢 | 330 | 155 | All SZGR 2.0 genes in this pathway |
| Reactome有丝分裂G1 G1 S相 | 137 | 79 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF MITOTIC CELL CYCLE | 85 | 46 | All SZGR 2.0 genes in this pathway |
| Reactome有丝分裂M M G1相 | 172 | 98 | All SZGR 2.0 genes in this pathway |
| 复制前复合物的反应组装 | 65 | 36 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 84 | 50 | All SZGR 2.0 genes in this pathway |
| AUF1 HNRNP D0对mRNA的反应组不稳定 | 53 | 31 | All SZGR 2.0 genes in this pathway |
| Reactome DNA复制 | 192 | 110 | All SZGR 2.0 genes in this pathway |
| REACTOME APOPTOSIS | 148 | 94 | All SZGR 2.0 genes in this pathway |
| Reactome HIV感染 | 207 | 122 | All SZGR 2.0 genes in this pathway |
| REACTOME HOST INTERACTIONS OF HIV FACTORS | 132 | 81 | All SZGR 2.0 genes in this pathway |
| Reactome APC C CDH1介导的CDC20和其他APC C CDH1靶向蛋白质的降解早期G1早期 | 72 | 38 | All SZGR 2.0 genes in this pathway |
| Reactome APC C CDC20介导的有丝分裂蛋白降解 | 73 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | 64 | 34 | All SZGR 2.0 genes in this pathway |
| Reactome SCF Beta TRCP介导的EMI1降解 | 51 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| Reactome适应性免疫系统 | 539 | 350 | All SZGR 2.0 genes in this pathway |
| Reactome I类MHC介导的抗原加工表现 | 251 | 156 | All SZGR 2.0 genes in this pathway |
| Reactome抗原加工泛素化蛋白酶体降解 | 212 | 129 | All SZGR 2.0 genes in this pathway |
| Reactome s阶段 | 109 | 66 | All SZGR 2.0 genes in this pathway |
| Reactome SCFSKP2介导的P27 P21降解 | 56 | 34 | All SZGR 2.0 genes in this pathway |
| Reactome VIF介导的apobec3g降解 | 52 | 30 | All SZGR 2.0 genes in this pathway |
| LAIHO COLORECTAL CANCER SERRATED UP | 112 | 71 | All SZGR 2.0 genes in this pathway |
| Ouellet培养的卵巢癌侵入性与LMP UP | 69 | 40 | All SZGR 2.0 genes in this pathway |
| Mattioli Mgus vs PCL | 116 | 62 | All SZGR 2.0 genes in this pathway |
| Spielman淋巴细胞欧洲vs亚洲 | 479 | 299 | All SZGR 2.0 genes in this pathway |
| 史密斯·泰特（Smith Tert） | 145 | 91 | All SZGR 2.0 genes in this pathway |
| tarte浆细胞与Plasmablast DN | 309 | 206 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 14HR DN | 298 | 200 | All SZGR 2.0 genes in this pathway |
| PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP | 64 | 40 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER T4 | 94 | 69 | All SZGR 2.0 genes in this pathway |
| Zheng由Foxp3绑定 | 491 | 310 | All SZGR 2.0 genes in this pathway |
| 由FOXP3绑定的Marson刺激 | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| LIN MELANOMA COPY NUMBER UP | 73 | 53 | All SZGR 2.0 genes in this pathway |
| 级结肠癌 | 871 | 505 | All SZGR 2.0 genes in this pathway |
| GRADE COLON AND RECTAL CANCER UP | 285 | 167 | All SZGR 2.0 genes in this pathway |
| Yoshimura MAPK8目标DN | 366 | 257 | All SZGR 2.0 genes in this pathway |
| 甜肺癌克拉斯 | 491 | 316 | All SZGR 2.0 genes in this pathway |
| ZHAN VARIABLE EARLY DIFFERENTIATION GENES DN | 30 | 19 | All SZGR 2.0 genes in this pathway |
| 开罗肝母细胞瘤 | 207 | 143 | All SZGR 2.0 genes in this pathway |
| lu eszh2靶向 | 295 | 155 | All SZGR 2.0 genes in this pathway |
| 棕熊UVC响应迟到 | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |