SZGR2 - Beplay体育中心

Summary？

基因	57144
象征	PAK7
Synonyms	PAK5
Description	P21蛋白（CDC42/RAC）激活激酶7
Reference	MIM：608038\|HGNC：HGNC：15916\|Ensembl:ENSG00000101349\|HPRD：06423\|Vega：Otthumg0000000031857
基因类型	蛋白质编码
Map location	20p12
Pascal p-value	0.731
Sherlock p-value	0.668
胎儿β	1.226
DMG	1(# studies)
主持人	小脑
Support	G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	1
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
GSMA_I	Genome scan meta-analysis	Psr: 0.046
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息

Section I. Genetics and epigenetics annotation

差异甲基化基因

Probe	染色体	位置	最近的基因	p（dis）	Beta (dis)	fdr（dis）	学习
CG18815779	20	9819789	PAK7	9.87E-5	-0.313	0.028	DMG：Wockner_2014

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0000166	nucleotide binding	IEA		-
去：0005515	蛋白质结合	IPI		17353931
去：0005524	ATP binding	IEA		-
去：0004674	protein serine/threonine kinase activity	IEA		-
GO：0016740	转移酶活性	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
去：0006468	protein amino acid phosphorylation	IEA		-
GO:0006916	抗凋亡	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005739	mitochondrion	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
AP2S1	AP17 \|AP17-DELTA \|拍手2	adaptor-related蛋白有限公司mplex 2, sigma 1 subunit	Affinity Capture-MS	Biogrid	17353931
CCDC59	BR22 \|DKFZP686K1021 \|FLJ10294 \|HSPC128 \|TAP26	coiled-coil domain containing 59	Affinity Capture-MS	Biogrid	17353931
CDC42	CDC42Hs \| G25K	cell division cycle 42 (GTP binding protein, 25kDa)	-	HPRD,BioGRID	11756552\|12032833
FHL3	MGC19547 \|MGC23614 \|MGC8696 \|Slim2	四个半域3	Two-hybrid	Biogrid	16189514
LZTS2	KIAA1813 \|Lapser1	leucine zipper, putative tumor suppressor 2	Two-hybrid	Biogrid	16189514
PDLIM7	LMP1	PDZ and LIM domain 7 (enigma)	Two-hybrid	Biogrid	16189514
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	与RAS相关的C3肉毒纤维毒素底物1（RHO家族，小GTP结合蛋白Rac1）	-	HPRD,BioGRID	11756552
RPA3	repa3	复制蛋白A3，14KDA	Affinity Capture-MS	Biogrid	17353931
S100A7	psor1 \|S100A7C	S100钙结合蛋白A7	Affinity Capture-MS	Biogrid	17353931
S100A9	60b8ag \|CAGB \|CFAG \|CGLB \|l1ag \|liag \|MAC387 \|Mif \|MRP14 \|nif \| P14	S100钙结合蛋白A9	Affinity Capture-MS	Biogrid	17353931
TUBGCP4	76p \|FLJ14797 \|GCP4	微管蛋白，伽玛复合物相关蛋白4	Two-hybrid	Biogrid	16189514

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG轴突指导	129	103	All SZGR 2.0 genes in this pathway
kegg焦点粘附	201	138	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
肌动蛋白细胞骨架的KEGG调节	216	144	All SZGR 2.0 genes in this pathway
KEGG肾细胞癌	70	60	All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY	36	31	All SZGR 2.0 genes in this pathway
SIG PIP3在心脏肌周期中发出信号	67	54	All SZGR 2.0 genes in this pathway
SIG CHEMOTAXIS	45	37	All SZGR 2.0 genes in this pathway
Rho GTPases对肌动蛋白细胞骨架的SIG调节	35	25	All SZGR 2.0 genes in this pathway
ST整合素信号通路	82	62	All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION	45	33	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
Reactome Axon指导	251	188	All SZGR 2.0 genes in this pathway
RAC的反应组激活	14	11	All SZGR 2.0 genes in this pathway
Robo受体的反应组信号传导	30	26	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP	456	228	All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合靶向	191	128	All SZGR 2.0 genes in this pathway
Wong IFNA2电阻DN	34	20	All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6	469	239	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP	439	257	All SZGR 2.0 genes in this pathway
西肾上腺皮质肿瘤DN	546	362	All SZGR 2.0 genes in this pathway
MEISSNER ES ICP带有H3K4ME3和H3K27ME3	14	8	All SZGR 2.0 genes in this pathway
Meissner Brain ICP带有H3K4ME3	32	17	All SZGR 2.0 genes in this pathway
Mikkelsen MEF ICP，带有H3K4ME3和H3K27ME3	38	34	All SZGR 2.0 genes in this pathway
Mikkelsen IPS ICP带有H3K4ME3和H327Me3	126	83	All SZGR 2.0 genes in this pathway
Mikkelsen ES ICP带有H3K4ME3和H3K27ME3	137	85	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN	115	73	All SZGR 2.0 genes in this pathway
Gobert核心少突胶质细胞分化	40	28	All SZGR 2.0 genes in this pathway
Delacroix Rar Bound ES	462	273	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-10	311	317	1a	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	311	317	1a	hsa-miR-10b	uacccuguagaaccgaauuugu
mir-101	1993	1999	1a	hsa-miR-101	uacaguacugauaacugaag
miR-135	1422	1428	M8	HSA-MIR-135A	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1422	1428	M8	HSA-MIR-135B	Uauggcuuuucauuccuaugug
miR-139	1337	1343	M8	HSA-MIR-139^brain	ucuacagugcacgugucu
miR-139	1337	1343	M8	HSA-MIR-139^brain	ucuacagugcacgugucu
miR-144	1993	1999	1a	HSA-MIR-144	UACAGUAUAGAUGAUGUACUAG
miR-145	1636	1643	1A，M8	HSA-MIR-145	guccaguuucccaggaaucccuu
miR-15/16/195/424/497	1247	1253	M8	HSA-MIR-15A^brain	uagcagcacauaugguugug
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				HSA-MIR-15B^brain	UAGCAGCACAUCAUGGUUUACA
				HSA-MIR-195^SZ	uagcagaaaaauauuggc
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				HSA-MIR-497	cagcagcacacuguguuugu
miR-17-5p/20/93.mr/106/519.d	394	400	M8	HSA-MIR-17-5P	caaagugcuuacugcagguagu
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	caaagugcuugugcagguag
				HSA-MIR-519D	caaagugccucccuuuagugugu
miR-181	1267	1273	M8	HSA-MIR-181A^brain	AACAUUCAACGCUGUCGGUGAGU
				HSA-MIR-181B^SZ	aacauucauugcugucggggg
				HSA-MIR-181C^brain	AACAUUCAACCUGUCGGUGAGU
				HSA-MIR-181D^brain	aacauucauuguugucggggguggguu
miR-185	179	186	1A，M8	HSA-MIR-185^brain	UGGAGAGAAAGGCAGUUC
miR-186	584	591	1A，M8	HSA-MIR-186	caaagaauuuugggcuu
miR-191	284	290	1a	HSA-MIR-191^brain	caacggaaucccaaaagcagcu
miR-200bc/429	1104	1111	1A，M8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
mir-208	165	171	1a	hsa-miR-208	auaagacgaaaaaagcuugu
miR-24	748	754	1a	hsa-miR-24^SZ	uggcucucagagcaggaagag
mir-30-5p	521	527	M8	HSA-MIR-30A-5P	uguaaaacauccuccugagaag
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	uguaaacauccuaccucucagcu
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
mir-320	627	634	1A，M8	hsa-miR-320	aaaagcugggugagaggggcgaa
mir-323	1220	1226	M8	hsa-miR-323^brain	gcacauuacggucgaccucu
mir-369-3p	232	238	1a	hsa-miR-369-3p	aauauacaugguugaucuuu
miR-374	232	238	M8	HSA-MIR-374	uuauaauacaAccugauaagug
miR-375	539	545	1a	HSA-MIR-375	UUUGUUCGUUCGGCUCGCGUGA
mir-376c	1811	1817	1a	HSA-MIR-376C	aacauagaggaaauuccacg
miR-495	1428	1434	1a	HSA-MIR-495^brain	Aaacaaacauggugcacuuuuu
miR-499	165	171	1a	HSA-MIR-499	UUAAGACUUGCAGUGAUGUUUAA
mir-543	1268	1274	M8	hsa-miR-543	aaacauucgcggugcacuucu
miR-93.hd/291-3p/294/295/302/372/373/520	393	399	M8	HSA-MIR-93^brain	aaagugcuguucgugcagguag
				hsa-miR-302a	uaagugcuugcauguuuguga
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	uaagugcuuccauguucagugg
				hsa-miR-302d	Uaagugcuauguugugugu
				HSA-MIR-372	AAAGUGCUGCGACAUUUGAGCGU
				HSA-MIR-373	Gaagugcuucgauuuggggugu
				HSA-MIR-520E	Aaagugcuuuuuugaggg
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	aaagugcuuuuuuagaggg
				hsa-miR-520c	aaagugcuuuuuuaggggug
				hsa-miR-520d	aaaguguuugugggguggguu

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:PAK7