Gene Page:BAG1
概括?
| 基因 | 573 |
| 象征 | BAG1 |
| Synonyms | BAG-1|HAP|RAP46 |
| Description | BCL2associated athanogene 1 |
| Reference | MIM:601497|HGNC:HGNC:937|Ensembl:ENSG00000107262|HPRD:03292|Vega:OTTHUMG00000019766 |
| Gene type | protein-coding |
| Map location | 9P12 |
| Pascal p-value | 0.001 |
| Sherlock P值 | 0.841 |
| Fetal beta | -0.598 |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| 表达 | 基因表达的荟萃分析 | Pvalue: 1.75 | |
| 文学 | High-throughput literature-search | 与精神分裂症关键词共同存在：精神分裂症，精神分裂症 | Click to show details |
第一节遗传学和表观遗传学注释
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
大脑区域的顶级共表达基因
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RNF123 | 0.87 | 0.87 |
| BAIAP2 | 0.86 | 0.87 |
| Rab40c | 0.86 | 0.86 |
| DUSP7 | 0.86 | 0.87 |
| GIT1 | 0.86 | 0.86 |
| SLC25A42 | 0.85 | 0.84 |
| JPH4 | 0.85 | 0.87 |
| lingo1 | 0.85 | 0.86 |
| NUMBL | 0.84 | 0.85 |
| 达格拉 | 0.84 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.62 | -0.58 |
| GNG11 | -0.59 | -0.61 |
| AL139819.3 | -0.58 | -0.61 |
| AP002478.3 | -0.57 | -0.57 |
| C1orf54 | -0.57 | -0.61 |
| NOSTRIN | -0.55 | -0.54 |
| MT-CO2 | -0.54 | -0.50 |
| AF347015.31 | -0.54 | -0.49 |
| AF347015.8 | -0.53 | -0.49 |
| AL050337.1 | -0.53 | -0.61 |
Section III. Gene Ontology annotation
| 分子功能 | 去term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005057 | receptor signaling protein activity | 塔斯 | 8947043 | |
| GO:0005515 | 蛋白质结合 | IEA | - | |
| GO:0005515 | 蛋白质结合 | 新闻学会 | 11222862 | |
| 生物过程 | 去term | Evidence | Neuro keywords | PubMed ID |
| 去：0006464 | 蛋白质改性过程 | IEA | - | |
| GO:0007166 | cell surface receptor linked signal transduction | 塔斯 | 8947043 | |
| 去：0006916 | anti-apoptosis | 塔斯 | 8947043 | |
| 去：0006915 | 凋亡 | IEA | - | |
| Cellular component | 去term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005737 | 细胞质 | 塔斯 | 8947043 |
第四节。蛋白质蛋白相互作用注释
| 互动者 | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| AR | AIS |DHTR |Humara |KD |NR3C4 |SBMA |smax1 |TFM | 雄激素受体 | - | HPRD,BioGRID | 11278763 |
| BCL2 | Bcl-2 | B-cell CLL/lymphoma 2 | - | HPRD,BioGRID | 9305631 |
| Bcl2l1 | BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xS | BCL2-like 1 | - | HPRD | 10467399 |
| ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | 雌激素受体1 | - | HPRD,BioGRID | 8524784 |
| HBEGF | DTR | DTS | DTSF | HEGFL | heparin-binding EGF-like growth factor | - | HPRD,BioGRID | 11340068 |
| HSPA1A | FLJ54303 | FLJ54370 | FLJ54392 | FLJ54408 | FLJ75127 | HSP70-1 | HSP70-1A | HSP70I | HSP72 | HSPA1 | HSPA1B | 热休克70KDA蛋白1A | Reconstituted Complex | BioGRID | 14517289 |
| HSPA4 | APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RY | heat shock 70kDa protein 4 | BAG1 interacts with Hsp70. | BIND | 15603737 |
| HSPA8 | HSC54 |HSC70 |HSC71 |HSP71 |HSP73 |HSPA10 |lap1 |MGC131511 |MGC29929 |NIP71 | heat shock 70kDa protein 8 | - | HPRD,BioGRID | 9305631 |
| 见面 | AUTS9 | HGFR | RCCP2 | c-Met | MET原始癌基因（肝细胞生长因子受体） | - | HPRD | 8947043 |
| NR3C1 | GCCR | GCR | GR | GRL | 核受体亚科3，C组，成员1（糖皮质激素受体） | - | HPRD,BioGRID | 11101523 |
| PDGFRB | CD140B |JTK12 |PDGF-R-BETA |PDGFR |PDGFR1 | platelet-derived growth factor receptor, beta polypeptide | - | HPRD | 8947043 |
| PPP1R15A | GADD34 | protein phosphatase 1, regulatory (inhibitor) subunit 15A | - | HPRD,BioGRID | 12724406 |
| PSMD1 | MGC133040 | MGC133041 | P112 | Rpn2 | S1 | 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，1 | - | HPRD | 10671488 |
| RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | - | HPRD,BioGRID | 8692945 |
| RARA | NR1B1 | RAR | retinoic acid receptor, alpha | - | HPRD,BioGRID | 9642262 |
| RB1 | OSRC | RB | p105-Rb | pRb | pp110 | retinoblastoma 1 | Affinity Capture-Western | BioGRID | 12845674 |
| SIAH1 | FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1 | seven in absentia homolog 1 (Drosophila) | - | HPRD,BioGRID | 9582267 |
| Stub1 | CHIP | HSPABP2 | NY-CO-7 | SDCCAG7 | UBOX1 | STIP1 homology and U-box containing protein 1 | - | HPRD,BioGRID | 11676916 |
| TP53 | FLJ92943 |LFS1 |trp53 |p53 | tumor protein p53 | Phenotypic Suppression | BioGRID | 9582267 |
| VDR | NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor | - | HPRD,BioGRID | 10967105 |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID AP1 PATHWAY | 70 | 60 | 该途径中的所有SZGR 2.0基因 |
| NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN | 634 | 384 | 该途径中的所有SZGR 2.0基因 |
| PUIFFE INVASION INHIBITED BY ASCITES DN | 145 | 91 | 该途径中的所有SZGR 2.0基因 |
| WAMUNYOKOLI OVARIAN CANCER LMP UP | 265 | 158 | 该途径中的所有SZGR 2.0基因 |
| WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP | 137 | 84 | 该途径中的所有SZGR 2.0基因 |
| 多德鼻咽癌 | 1821 | 933 | 该途径中的所有SZGR 2.0基因 |
| PROVENZANI METASTASIS UP | 194 | 112 | 该途径中的所有SZGR 2.0基因 |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | 该途径中的所有SZGR 2.0基因 |
| FARMER BREAST CANCER APOCRINE VS LUMINAL | 326 | 213 | 该途径中的所有SZGR 2.0基因 |
| Schlosser MYC靶标和血清反应 | 47 | 32 | 该途径中的所有SZGR 2.0基因 |
| AIYAR COBRA1 TARGETS DN | 29 | 18 | 该途径中的所有SZGR 2.0基因 |
| DACOSTA UV RESPONSE VIA ERCC3 UP | 309 | 199 | 该途径中的所有SZGR 2.0基因 |
| 温曼对缺氧的适应 | 29 | 24 | 该途径中的所有SZGR 2.0基因 |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 该途径中的所有SZGR 2.0基因 |
| GARCIA TARGETS OF FLI1 AND DAX1 DN | 176 | 104 | 该途径中的所有SZGR 2.0基因 |
| DER IFN ALPHA RESPONSE UP | 74 | 48 | 该途径中的所有SZGR 2.0基因 |
| der ifn beta响应 | 102 | 67 | 该途径中的所有SZGR 2.0基因 |
| TARTE PLASMA CELL VS PLASMABLAST DN | 309 | 206 | 该途径中的所有SZGR 2.0基因 |
| DER IFN GAMMA RESPONSE UP | 71 | 45 | 该途径中的所有SZGR 2.0基因 |
| ZAMORA NOS2 TARGETS UP | 69 | 41 | 该途径中的所有SZGR 2.0基因 |
| NATSUME RESPONSE TO INTERFERON BETA DN | 52 | 33 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE UP | 1691年 | 1088 | 该途径中的所有SZGR 2.0基因 |
| SESTO RESPONSE TO UV C0 | 107 | 72 | 该途径中的所有SZGR 2.0基因 |
| JACKSON DNMT1 TARGETS UP | 77 | 57 | 该途径中的所有SZGR 2.0基因 |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN | 287 | 208 | 该途径中的所有SZGR 2.0基因 |
| Krige对Tosedostat 6小时DN的响应 | 911 | 527 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | 该途径中的所有SZGR 2.0基因 |
| riggins他莫昔芬抗性 | 66 | 44 | 该途径中的所有SZGR 2.0基因 |
| MARZEC IL2 SIGNALING UP | 115 | 80 | 该途径中的所有SZGR 2.0基因 |
| BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING | 246 | 152 | 该途径中的所有SZGR 2.0基因 |
| LABBE WNT3A TARGETS UP | 112 | 71 | 该途径中的所有SZGR 2.0基因 |
| BHATI G2M ARREST BY 2METHOXYESTRADIOL DN | 127 | 75 | 该途径中的所有SZGR 2.0基因 |
| WANG TUMOR INVASIVENESS UP | 374 | 247 | 该途径中的所有SZGR 2.0基因 |
| VANTVEER BREAST CANCER ESR1 UP | 167 | 99 | 该途径中的所有SZGR 2.0基因 |
| 4EBP1和4EBP2的COLINA目标 | 356 | 214 | 该途径中的所有SZGR 2.0基因 |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 | 181 | 101 | 该途径中的所有SZGR 2.0基因 |
| SASSON RESPONSE TO GONADOTROPHINS UP | 91 | 59 | 该途径中的所有SZGR 2.0基因 |
| SASSON RESPONSE TO FORSKOLIN UP | 90 | 58 | 该途径中的所有SZGR 2.0基因 |
| BAE BRCA1 TARGETS DN | 32 | 27 | 该途径中的所有SZGR 2.0基因 |
| KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | 该途径中的所有SZGR 2.0基因 |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | 该途径中的所有SZGR 2.0基因 |
| HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN | 103 | 67 | 该途径中的所有SZGR 2.0基因 |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | 该途径中的所有SZGR 2.0基因 |