Gene Page:XPO5

Summary?
GeneID 57510
Symbol XPO5
Synonyms exp5
Description exportin 5
Reference MIM:607845|HGNC:HGNC:17675|Ensembl:ENSG00000124571|HPRD:06385|Vega:OTTHUMG00000014742
Gene type protein-coding
Map location 6p21.1
Pascal p-value 3.634E-5
Sherlock p-value 0.03
Fetal beta 1.472
DMG 1 (# studies)
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.04433

部分即遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg26468274 6 43544000 XPO5;POLH 2.721E-4 -0.329 0.038 DMG:Wockner_2014
cg07099407 6 43027930 XPO5 0.001 3.607 DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000049 tRNA binding IEA -
GO:0005515 protein binding 新闻学会 12702765|17353931
GO:0008565 protein transporter activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006611 protein export from nucleus IEA -
GO:0031047 gene silencing by RNA IEA -
GO:0015031 protein transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -
GO:0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
EEF1A1 CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1 eukaryotic translation elongation factor 1 alpha 1 - HPRD,BioGRID 12426393
FADD GIG3 | MGC8528 | MORT1 Fas (TNFRSF6)-associated via death domain - HPRD 12702765
GSTK1 GST13 glutathione S-transferase kappa 1 Affinity Capture-MS BioGRID 17353931
ILF3 CBTF | DRBF | DRBP76 | MMP4 | MPHOSPH4 | MPP4 | NF-AT-90 | NF110 | NF90 | NFAR | NFAR-1 | NFAR2 | TCP110 | TCP80 interleukin enhancer binding factor 3, 90kDa - HPRD,BioGRID 11777942
MAGEA6 MAGE-3b | MAGE3B | MAGE6 | MGC52297 melanoma antigen family A, 6 Affinity Capture-MS BioGRID 17353931
NEK6 SID6-1512 NIMA (never in mitosis gene a)-related kinase 6 Affinity Capture-MS BioGRID 17353931
NUP153 HNUP153 | N153 nucleoporin 153kDa - HPRD,BioGRID 11777942
NUP214 CAIN | CAN | D9S46E | MGC104525 | N214 nucleoporin 214kDa - HPRD,BioGRID 11777942
PHLDA3 TIH1 pleckstrin homology-like domain, family A, member 3 Affinity Capture-MS BioGRID 17353931
PTP4A3 PRL-3 | PRL-R | PRL3 protein tyrosine phosphatase type IVA, member 3 Affinity Capture-MS BioGRID 17353931
RAN ARA24 | Gsp1 | TC4 RAN, member RAS oncogene family - HPRD,BioGRID 11777942
SERINC3 AIGP1 | DIFF33 | SBBI99 | TDE | TDE1 | TMS-1 serine incorporator 3 Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME MICRORNA MIRNA BIOGENESIS 23 9 All SZGR 2.0 genes in this pathway
REACTOME REGULATORY RNA PATHWAYS 26 12 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA UP 92 57 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430 232 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335 193 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180 101 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390 236 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 All SZGR 2.0 genes in this pathway
BILD MYC ONCOGENIC SIGNATURE 206 117 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124/506 888 894 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-29 1290 1296 m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-34/449 81 88 1A,m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC