Gene Page:NYNRIN

Summary?
GeneID 57523
Symbol NYNRIN
Synonyms CGIN1|KIAA1305
Description NYN domain and retroviral integrase containing
Reference HGNC:HGNC:20165|Ensembl:ENSG00000205978|Vega:OTTHUMG00000171314
Gene type protein-coding
Map location 14q12
Pascal p-value 0.516
Sherlock p-value 0.152
Fetal beta 2.607
eGene Myers' cis & trans
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
NYNRIN chr14 24884073 C T NM_025081 p.1040R>W missense Schizophrenia DNM:Fromer_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6687849 chr1 175904808 NYNRIN 57523 0.13 trans
rs2481653 chr1 176044120 NYNRIN 57523 0.17 trans
rs2502827 chr1 176044216 NYNRIN 57523 0.01 trans
rs17572651 chr1 218943612 NYNRIN 57523 0.06 trans
rs16829545 chr2 151977407 NYNRIN 57523 2.59E-19 trans
rs16841750 chr2 158288461 NYNRIN 57523 0.03 trans
rs3845734 chr2 171125572 NYNRIN 57523 5.374E-5 trans
rs7584986 chr2 184111432 NYNRIN 57523 1.899E-13 trans
rs6741060 chr2 217169088 NYNRIN 57523 0.14 trans
rs9810143 chr3 5060209 NYNRIN 57523 0.02 trans
rs2183142 chr4 159232695 NYNRIN 57523 0.06 trans
rs170776 chr4 173276735 NYNRIN 57523 0.11 trans
rs1396222 chr4 173279496 NYNRIN 57523 0.05 trans
rs335980 chr4 173329784 NYNRIN 57523 0.07 trans
rs335982 chr4 173330945 NYNRIN 57523 0.14 trans
rs337984 chr4 173411662 NYNRIN 57523 0.07 trans
rs17762315 chr5 76807576 NYNRIN 57523 0.08 trans
rs10491487 chr5 80323367 NYNRIN 57523 0.03 trans
rs9461864 chr6 33481468 NYNRIN 57523 0.06 trans
rs16890367 chr6 38078448 NYNRIN 57523 0.07 trans
rs3118341 chr9 25185518 NYNRIN 57523 0.02 trans
rs9406868 chr9 25223372 NYNRIN 57523 0.17 trans
rs11139334 chr9 84209393 NYNRIN 57523 0.03 trans
rs6480454 chr10 72108174 NYNRIN 57523 0.15 trans
rs12253651 chr10 72109045 NYNRIN 57523 0.15 trans
rs17104720 chr14 77127308 NYNRIN 57523 0.07 trans
rs16955618 chr15 29937543 NYNRIN 57523 1.787E-32 trans
rs11873184 chr18 1584081 NYNRIN 57523 0.08 trans
rs1041786 chr21 22617710 NYNRIN 57523 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某羊乳酪l (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0015074 DNA integration IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
SOTIRIOU BREAST CANCER GRADE 1 VS 3 DN 52 34 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN 182 111 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREY DN 74 44 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162 116 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193 112 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207 145 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN 209 137 All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297 194 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 706 713 1A,m8 hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-124/506 103 109 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-15/16/195/424/497 45 52 1A,m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-503 46 52 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG