Gene Page:SEMA6A

Summary?
GeneID 57556
Symbol SEMA6A
Synonyms HT018|SEMA|SEMA6A1|SEMAQ|VIA
Description semaphorin 6A
Reference MIM:605885|HGNC:HGNC:10738|Ensembl:ENSG00000092421|HPRD:06906|Vega:OTTHUMG00000162987
Gene type protein-coding
Map location 5q23.1
Pascal p-value 0.257
DEG p-value DEG:Zhao_2015:p=2.24e-05:q=0.0404
Fetal beta 0.706
eGene Hippocampus

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DEG:Zhao_2015 RNA Sequencing analysis Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.
PMID:cooccur High-throughput literature-search 系统的搜索in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Expression Meta-analysis of gene expression Pvalue: 2.144
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IEA -
GO:0005515 protein binding 新闻学会 10993894
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007411 axon guidance NAS axon (GO term level: 13) 10993894
GO:0007399 nervous system development NAS neurite (GO term level: 5) 10993894
GO:0007010 cytoskeleton organization NAS 10993894
GO:0009887 organ morphogenesis NAS 10993894
GO:0007166 细胞surface receptor linked signal transduction NAS 10993894
GO:0006915 apoptosis NAS 10993894
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0030424 axon NAS neuron, axon, Neurotransmitter (GO term level: 6) 10993894
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0016021 integral to membrane NAS 10993894

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME OTHER SEMAPHORIN INTERACTIONS 15 14 All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS 68 53 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS UP 77 62 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229 142 All SZGR 2.0 genes in this pathway
LI CISPLATIN RESISTANCE DN 35 20 All SZGR 2.0 genes in this pathway
SHI SPARC TARGETS UP 24 17 All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS UP 201 127 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 UP 57 34 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236 139 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
BHATTACHARYA EMBRYONIC STEM CELL 89 60 All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293 193 All SZGR 2.0 genes in this pathway
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70 67 33 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA UP 98 64 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP 175 116 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY UP 86 48 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE DN 61 39 All SZGR 2.0 genes in this pathway
OSADA ASCL1 TARGETS UP 46 30 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216 143 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN 170 105 All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP 105 75 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN 74 47 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 All SZGR 2.0 genes in this pathway
DN CHYLA CBFA2T3目标 242 146 All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 2 DN 32 23 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
NABA ECM附属 171 89 All SZGR 2.0 genes in this pathway
NABA MATRISOMEASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 1306 1312 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 1305 1312 1A,m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-128 568 574 1A hsa-miR-128a UCACAGUGAACCGGUCUCUUUU
hsa-miR-128b UCACAGUGAACCGGUCUCUUUC
miR-132/212 3044 3050 m8 hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
hsa-miR-132brain UAACAGUCUACAGCCAUGGUCG
miR-141/200a 584 591 1A,m8 hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-144 566 572 m8 hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-145 813 820 1A,m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/497 1216 1222 1A hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-218 298 304 m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-27 1273 1279 1A hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-30-5p 2038 2044 m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-331 3 9 m8 hsa-miR-331brain GCCCCUGGGCCUAUCCUAGAA
miR-338 1210 1216 m8 hsa-miR-338brain UCCAGCAUCAGUGAUUUUGUUGA
miR-375 2053 2059 1A hsa-miR-375 UUUGUUCGUUCGGCUCGCGUGA
miR-377 1198 1204 1A hsa-miR-377 AUCACACAAAGGCAACUUUUGU
miR-496 1294 1301 1A,m8 hsa-miR-496 AUUACAUGGCCAAUCUC
miR-503 1216 1222 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG
miR-7 738 744 1A hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG
miR-96 1540 1546 m8 hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC