Gene Page:USP36

Summary?
GeneID 57602
Symbol USP36
Synonyms DUB1
Description ubiquitin specific peptidase 36
Reference MIM:612543|HGNC:HGNC:20062|Ensembl:ENSG00000055483|HPRD: 07164|Vega:OTTHUMG00000177542
Gene type protein-coding
Map location 17q25.3
Pascal p-value 0.004
Sherlock p-value 0.911
DMG 1 (# studies)
eGene Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
Expression 元-analysis of gene expression Pvalue: 2.033

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg27021056 17 76837047 USP36 2.451E-4 -0.224 0.037 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10512617 chr17 76693550 USP36 57602 1.207E-7 cis
rs17736494 chr17 76728667 USP36 57602 3.699E-8 cis
rs1384367 chr17 76729756 USP36 57602 7.953E-8 cis
rs8182269 chr17 76789990 USP36 57602 3.186E-6 cis
rs10512617 chr17 76693550 USP36 57602 2.646E-5 trans
rs17736494 chr17 76728667 USP36 57602 8.54E-6 trans
rs1384367 chr17 76729756 USP36 57602 1.758E-5 trans
rs8182269 chr17 76789990 USP36 57602 5.581E-4 trans
rs3744802 17 76793600 USP36 ENSG00000055483.15 9.501E-7 0.02 43923 gtex_brain_putamen_basal
rs3826552 17 76793885 USP36 ENSG00000055483.15 9.134E-7 0.02 43638 gtex_brain_putamen_basal
rs2306526 17 76798362 USP36 ENSG00000055483.15 4.587E-7 0.02 39161 gtex_brain_putamen_basal
rs3088040 17 76799860 USP36 ENSG00000055483.15 1.811E-6 0.02 37663 gtex_brain_putamen_basal
rs9302885 17 76799898 USP36 ENSG00000055483.15 1.584E-6 0.02 37625 gtex_brain_putamen_basal
rs11649964 17 76800182 USP36 ENSG00000055483.15 7.396E-7 0.02 37341 gtex_brain_putamen_basal
rs6501250 17 76808726 USP36 ENSG00000055483.15 4.688E-7 0.02 28797 gtex_brain_putamen_basal
rs7220532 17 76808773 USP36 ENSG00000055483.15 4.682E-7 0.02 28750 gtex_brain_putamen_basal
rs202089733 17 76809351 USP36 ENSG00000055483.15 1.151E-6 0.02 28172 gtex_brain_putamen_basal
rs1110274 17 76810284 USP36 ENSG00000055483.15 5.204E-7 0.02 27239 gtex_brain_putamen_basal
rs7218605 17 76811803 USP36 ENSG00000055483.15 5.481E-7 0.02 25720 gtex_brain_putamen_basal
rs2376828 17 76812840 USP36 ENSG00000055483.15 1.797E-6 0.02 24683 gtex_brain_putamen_basal
rs11650000 17 76828154 USP36 ENSG00000055483.15 1.475E-6 0.02 9369 gtex_brain_putamen_basal
rs4352096 17 76833916 USP36 ENSG00000055483.15 1.024E-6 0.02 3607 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NDC80 0.99 0.76
SGOL1 0.98 0.75
TTK 0.98 0.75
MELK 0.98 0.75
HMGB2 0.98 0.59
EXO1 0.98 0.71
DLGAP5 0.97 0.79
KIF23 0.97 0.73
PBK 0.97 0.75
CCNB2 0.97 0.77
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SLC9A3R2 -0.38 -0.55
FBXO2 -0.36 -0.64
ASPHD1 -0.36 -0.61
PTH1R -0.36 -0.63
HLA-F -0.36 -0.65
TNFSF12 -0.35 -0.62
C5orf53 -0.35 -0.62
ADAP1 -0.34 -0.41
LHPP -0.34 -0.58
CA4 -0.34 -0.67

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004221 泛素thiolesterase活动vity IEA -
GO:0008234 cysteine-type peptidase activity IEA -
GO:0008233 peptidase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006511 ubiquitin-dependent protein catabolic process IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
WANG LMO4 TARGETS UP 372 227 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 78 41 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240 171 All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176 123 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE UP 85 57 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205 126 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216 143 All SZGR 2.0 genes in this pathway
BEIER GLIOMA STEM CELL DN 66 42 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway