Gene Page:KLHL1

Summary?
GeneID 57626
Symbol KLHL1
Synonyms MRP2
Description kelch like family member 1
Reference MIM:605332|HGNC:HGNC:6352|Ensembl:ENSG00000150361|HPRD:05623|Vega:OTTHUMG00000017056
Gene type protein-coding
Map location 13q21
Pascal p-value 0.003
Fetal beta 3.697

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统的搜索页ubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 4

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg12917718 13 70682019 KLHL1;ATXN8OS 9.84E-5 -0.214 0.028 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003779 actin binding NAS 10888605
GO:0005515 protein binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0021680 cerebellar Purkinje cell layer development IEA neuron, axon, Synap, dendrite (GO term level: 12) -
GO:0016358 dendrite development IEA neurite, dendrite (GO term level: 11) -
GO:0007628 adult walking behavior IEA -
GO:0007626 运动的行为 IEA -
GO:0030036 actin cytoskeleton organization NAS 10888605
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0043025 cell soma IEA axon, dendrite (GO term level: 4) -
GO:0030425 dendrite IEA neuron, axon, dendrite (GO term level: 6) -
GO:0005856 cytoskeleton IEA -
GO:0005737 cytoplasm NAS 10888605

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
LEIN MIDBRAIN MARKERS 82 55 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K4ME3 AND H3K27ME3 38 34 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 126 83 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 137 85 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-24 727 734 1A,m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-452 669 675 1A hsa-miR-452 UGUUUGCAGAGGAAACUGAGAC
miR-496 1061 1068 1A,m8 hsa-miR-496 AUUACAUGGCCAAUCUC
miR-9 732 738 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA