Gene Page:PCDHB16
Summary?
| GeneID | 57717 |
| Symbol | PCDHB16 |
| Synonyms | ME1|PCDH-BETA16|PCDH3X|PCDHB8a |
| Description | protocadherin beta 16 |
| Reference | MIM:606345|HGNC:HGNC:14546|Ensembl:ENSG00000272674|HPRD:06961|Vega:OTTHUMG00000188325 |
| Gene type | protein-coding |
| Map location | 5q31 |
| Pascal p-value | 0.041 |
| Sherlock p-value | 0.212 |
| eGene | Cerebellar Hemisphere Cerebellum |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0032 | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| A2ML1 | 0.71 | 0.67 |
| EPHX2 | 0.70 | 0.67 |
| KANK1 | 0.69 | 0.70 |
| NFATC1 | 0.68 | 0.58 |
| SLC12A4 | 0.68 | 0.65 |
| ITPKB | 0.68 | 0.69 |
| RYR1 | 0.67 | 0.76 |
| PIPOX | 0.67 | 0.65 |
| PBXIP1 | 0.67 | 0.72 |
| ADHFE1 | 0.67 | 0.70 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BZW2 | -0.52 | -0.53 |
| CCNI | -0.52 | -0.52 |
| SSBP2 | -0.51 | -0.50 |
| AC027307.2 | -0.51 | -0.47 |
| VASH2 | -0.50 | -0.45 |
| DACT1 | -0.50 | -0.46 |
| SLA | -0.50 | -0.43 |
| FAM117B | -0.50 | -0.44 |
| PAK7 | -0.50 | -0.45 |
| FANCE | -0.50 | -0.45 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | - | |
| GO:0005515 | protein binding | NAS | 11322959 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0007416 | synaptogenesis | TAS | Synap (GO term level: 6) | 12231349 |
| GO:0007268 | synaptic transmission | TAS | neuron, Synap, Neurotransmitter (GO term level: 6) | 12231349 |
| GO:0007155 | cell adhesion | IEA | - | |
| GO:0007156 | homophilic cell adhesion | IEA | - | |
| GO:0016339 | calcium-dependent cell-cell adhesion | NAS | 11322959 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | NAS | 11322959 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| RODRIGUES DCC TARGETS DN | 121 | 84 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP | 211 | 136 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS WITH HCP H3K27ME3 | 102 | 76 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES HCP WITH H3K27ME3 | 41 | 30 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 1 UP | 125 | 61 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 UP | 170 | 97 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
| PEDRIOLI MIR31 TARGETS DN | 418 | 245 | All SZGR 2.0 genes in this pathway |