SZGR2 - Beplay体育中心

Summary?

基因	58
象征	ACTA1
同义词	ACTA\|ASMA\|CFTD\|CFTD1\|CFTDM\|MPFD\|NEM1\|NEM2\|NEM3\|SHPM
描述	肌动蛋白，α1，骨骼肌
参考	MIM:102610\|HGNC：HGNC：129\|Ensembl:ENSG00000143632\|HPRD:00030\|Vega:OTTHUMG00000038006
Gene type	protein-coding
地图位置	1Q42.13
Fetal beta	-0.745
DMG	1（＃研究）

Gene in Data Sources

Gene set name	基因组方法	描述	Info
简历：PGCNP	全基因组协会研究	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	高通量文献搜索	系统的搜索在酒吧Med for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学	高通量文献搜索	与精神分裂症关键词共同存在：精神分裂症，精神分裂症	Click to show details
网络	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.1982

Section I. Genetics and epigenetics annotation

差异甲基化基因

探测	Chromosome	Position	最近的基因	P (dis)	beta（dis）	FDR (dis)	Study
CG07777790	1	229570188	ACTA1	5.516E-4	-0.366	0.049	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0000166	核苷酸结合	IEA		-
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	新闻学会		12849983
GO:0005524	ATP结合	IEA		-
GO:0005524	ATP结合	塔斯		10508519
去：0005198	结构分子活性	IEA		-
GO:0005200	structural constituent of cytoskeleton	塔斯		10508519
GO:0017022	肌球蛋白结合	塔斯		10508519
GO:0043531	ADP binding	塔斯		10508519
生物过程	去的术语	Evidence	Neuro keywords	PubMed ID
GO：0030240	muscle thin filament assembly	小鬼		11333380
GO:0006936	肌肉收缩	塔斯		10508519
GO:0048741	骨骼肌纤维发育	ISS		-
细胞分量	去的术语	Evidence	Neuro keywords	PubMed ID
去：0001725	stress fiber	艾达		15198992
GO:0005856	cytoskeleton	IEA		-
GO:0005865	striated muscle thin filament	艾达		15198992
GO:0005737	cytoplasm	IEA		-
GO:0005884	肌动蛋白丝	艾达		12849983

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTR10	Actr11 \|HARP11	肌动蛋白相关蛋白10同源物（酿酒酵母）	-	HPRD	12857853
APC2	APCL	adenomatosis polyposis coli 2	共定位	BioGRID	11691822
CCT4	cct-delta \|CCTD \|MGC126164 \|MGC126165 \|SRB	chaperonin containing TCP1, subunit 4 (delta)	-	HPRD，Biogrid	11580270
CCT5	cct-epsilon \|CCTE \|KIAA0098 \|TCP-1- epsilon	chaperonin containing TCP1, subunit 5 (epsilon)	-	HPRD，Biogrid	11580270
CDH2	CD325 \| CDHN \| CDw325 \| NCAD	钙粘蛋白2，1型，N-钙粘蛋白（神经元）	Affinity Capture-Western	BioGRID	12438242
CFL1	CFL	cofilin 1 (non-muscle)	亲和力捕获ms	BioGRID	11950878
CFL1	CFL	cofilin 1 (non-muscle)	-	HPRD	11707283
CNN1	SMCC \|Sm-Calp	钙蛋白1，基本的平滑肌	Reconstituted Complex	BioGRID	2161834
CSNK1A1	CK1 \| HLCDGP1 \| PRO2975	酪蛋白激酶1，α1	亲和力捕获ms	BioGRID	12062430
DMD	BMD \|CMD3B \|DXS142 \|DXS164 \|DXS206 \|DXS230 \|DXS239 \|DXS268 \|DXS269 \|DXS270 \| DXS272	肌营养不良	-	HPRD，Biogrid	1544421 \| 11259305
DMD	BMD \|CMD3B \|DXS142 \|DXS164 \|DXS206 \|DXS230 \|DXS239 \|DXS268 \|DXS269 \|DXS270 \| DXS272	肌营养不良	-	HPRD	1544421
DNASE1	DKFZP686H0155 \|DNL1 \|Drni \|FLJ38093 \|FLJ44902	deoxyribonuclease I	-	HPRD	11707283
DNMBP	KIAA1010 \|图巴	dynamin binding protein	-	HPRD，Biogrid	14506234
DVL1L1	DSH \|DVL \|DVL-22 \|DVL1 \|DVL4	Dished，DSH同源1（果蝇） - 类似1	Affinity Capture-Western	BioGRID	12384700
EPB41	4.1R \| EL1 \| HE	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	-	HPRD	11071908
ETV6	电话\|电话/abl	ETS变体6	共定位	BioGRID	9695962
FGD4	CMT4H \| DKFZp313E1818 \| DKFZp434K1572 \| FLJ34370 \| FLJ42663 \| FRABP \| MGC57222 \| ZFYVE6	FYVE, RhoGEF and PH domain containing 4	-	HPRD	9668039\|11429692
FSCN1	FLJ38511 \| SNL \| p55	FASTIN同源物1，肌动蛋白捆绑蛋白（purvuratus strongylocentrotus）	-	HPRD，Biogrid	8999969
GAS7	KIAA0394 \| MGC1348 \| MLL/GAS7	growth arrest-specific 7	-	HPRD	11795944
GC	DBP \| DBP/GC \| VDBG \| VDBP	group-specific component (vitamin D binding protein)	Co-crystal Structure	BioGRID	12554937
GC	DBP \| DBP/GC \| VDBG \| VDBP	group-specific component (vitamin D binding protein)	-	HPRD	12119014
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	生长因子受体结合蛋白2	亲和力捕获ms	BioGRID	12577067
GSN	DKFZp313L0718	凝胶素（淀粉样变性，芬兰类型）	-	HPRD，Biogrid	10583954
hip1r	FLJ14000 \|FLJ27022 \|HIP12 \|hip3 \|ilweq \|KIAA0655 \|MGC47513	huntingtin interacting protein 1 related	-	HPRD	11889126
JUB	Ajuba \|MGC15563	jub, ajuba homolog (Xenopus laevis)	-	HPRD	12417594
KLHL20	khlhx \|Kleip \|klhlx \|RP3-383J4.3	类似Kelch的20（果蝇）	-	HPRD，Biogrid	14668487
标记4	FLJ90097 \|KIAA1860 \|markl1 \|NBLA00650	MAP/microtubule affinity-regulating kinase 4	亲和力捕获ms	BioGRID	14594945
MIB2	FLJ20648 \| FLJ39787 \| ZZANK1 \| ZZZ5	Mindbomb同源2（果蝇）	Reconstituted Complex Two-hybrid	BioGRID	14507647
MLPH	MGC2771 \| MGC59733 \| SLAC2-A	黑色素蛋白	Affinity Capture-Western	BioGRID	15059972
MYL1	MLC1F \| MLC3F	肌球蛋白，轻链1，碱；骨骼，快	-	HPRD	11707283
NRAP	-	nebulin-related anchoring protein	Reconstituted Complex	BioGRID	10320340
帕尔瓦	FLJ10793 \|FLJ12254 \|MXRA2	帕尔文，阿尔法	-	HPRD	11171322
PCYT1B	CCT-beta \| CTB	磷酸盐溶解酶1，胆碱，β	-	HPRD，Biogrid	11580270
PFDN1	PDF \| PFD1	preoldin亚基1	Reconstituted Complex	BioGRID	14634002
PFN1	-	profilin 1	-	HPRD	8413665
PHACTR1	KIAA1733 \|MGC126575 \|MGC126577 \|rpel \|rpel1 \|DJ257A7.2	磷酸酶和肌动蛋白调节剂1	-	HPRD，Biogrid	15107502
PLDN	PA \| PALLID	pallidin homolog (mouse)	-	HPRD	12019270
PPP1CA	MGC15877 \|MGC1674 \|PP-1A \|PPP1A	protein phosphatase 1, catalytic subunit, alpha isoform	Affinity Capture-Western	BioGRID	15107502
PPP1R9B	FLJ30345 \| PPP1R6 \| PPP1R9 \| SPINO \| Spn	protein phosphatase 1, regulatory (inhibitor) subunit 9B	Reconstituted Complex	BioGRID	12417592
PRKCA	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	蛋白激酶C，α	-	HPRD，Biogrid	10628374
PRKCE	MGC125656 \|MGC125657 \|PKCE \|npkc-epsilon	protein kinase C, epsilon	亲和力捕获ms Affinity Capture-Western	BioGRID	11897493
Rac1	MGC111543 \|Mig5 \|TC-25 \|P21-RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	-	HPRD	11027608
RPS6KB1	PS6K \|S6K \|S6K1 \|STK14A \|P70（S6K）-Alpha \|P70-S6K \|P70-Alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	Reconstituted Complex	BioGRID	15149849
S100A4	18a2 \|42a \|capl \|FSP1 \|MTS1 \|p9ka \|Pel98	S100 calcium binding protein A4	-	HPRD	14640694
sc	KIAA1905	scinderin	Reconstituted Complex	BioGRID	12438125
tagln	DKFZP686P11128 \|SM22 \|SMCC \|tagln1 \|WS3-10	跨胶结素	-	HPRD，Biogrid	11053353
测试工程师	DKFZp586B2022 \| MGC1146 \| TESS \| TESS-2	testis derived transcript (3 LIM domains)	Affinity Capture-Western	BioGRID	12695497
TLN1	ilweq \|KIAA1027 \| TLN	talin 1	-	HPRD	10581178
TMSB4X	FX \| PTMB4 \| TB4X \| TMSB4	thymosin beta 4, X-linked	-	HPRD，Biogrid	11812134
TMSB4Y	MGC26307 \|TB4Y	胸腺素β4，Y连锁	Reconstituted Complex	BioGRID	8416954
tnni3	CMD2A \|CMH7 \|MGC116817 \|tnnc1 \|ctni	troponin I type 3 (cardiac)	-	HPRD	12383268
tnni3K	CARK \| MGC142099 \| MGC33828	TNNI3相互作用激酶	-	HPRD，Biogrid	12721663
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF受体相关因子3	-	HPRD	11950878
TRIP6	MGC10556 \| MGC10558 \| MGC29959 \| MGC3837 \| MGC4423 \| OIP1 \| ZRP-1	甲状腺激素受体相互作用6	共定位	BioGRID	14688263
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	结节硬化症1	共定位	BioGRID	10806479
VCL	CMD1W \| MVCL	vinculin	-	HPRD	7816144
XIRP1	cmya1 \|DKFZP451D042 \|DKFZP779C1255 \|DKFZP779C1947 \|XIN	xin actin-binding repeat containing 1	-	HPRD	15454575
XPO6	EXP6 \| FLJ22519 \| KIAA0370 \| RANBP20	exportin 6	亲和力捕获ms	BioGRID	14592989

部分诉通路注释

Pathway name	Pathway size	＃szgr 2.0基因	Info
Biocarta No1途径	33	24	All SZGR 2.0 genes in this pathway
Biocarta AGR途径	36	31	All SZGR 2.0 genes in this pathway
Biocarta Epha4途径	10	8	All SZGR 2.0 genes in this pathway
BIOCARTA SALMONELLA PATHWAY	13	10	All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY	34	28	All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY	38	29	All SZGR 2.0 genes in this pathway
Biocarta McAlpain途径	25	16	All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY	56	45	All SZGR 2.0 genes in this pathway
BIOCARTA RAB PATHWAY	12	8	All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY	19	17	All SZGR 2.0 genes in this pathway
Biocarta遇到了途径	37	30	All SZGR 2.0 genes in this pathway
BIOCARTA HSP27 PATHWAY	15	11	All SZGR 2.0 genes in this pathway
BIOCARTA UCALPAIN PATHWAY	18	11	All SZGR 2.0 genes in this pathway
BIOCARTA ACTINY PATHWAY	20	14	All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY	45	33	All SZGR 2.0 genes in this pathway
PID AP1途径	70	60	All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY	52	39	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
Berenjeno由Rhoa转变为可逆DN	29	21	All SZGR 2.0 genes in this pathway
Markey RB1慢性LOF DN	118	78	All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment	536	340	All SZGR 2.0 genes in this pathway
Darwiche皮肤肿瘤启动子DN	185	115	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN	165	107	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN	180	110	All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN	181	107	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER F	54	32	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
彭葡萄糖剥夺	48	26	All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE UP	50	36	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP	157	105	All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE DN	19	12	All SZGR 2.0 genes in this pathway
CROMER METASTASIS DN	81	58	All SZGR 2.0 genes in this pathway
lu衰老的脑dn	153	120	All SZGR 2.0 genes in this pathway
Lee Calorie限制性新皮层	83	66	All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN	86	66	All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP	89	51	All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP	103	69	All SZGR 2.0 genes in this pathway
Aprelikova BRCA1目标	49	33	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN	178	121	All SZGR 2.0 genes in this pathway
Kuninger IGF1与PDGFB的目标	82	51	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向	601	369	All SZGR 2.0 genes in this pathway
Sarrio上皮间质转变DN	154	101	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
Yauch刺猬信号传导旁分泌DN	264	159	All SZGR 2.0 genes in this pathway
炎症反应和胆固醇DN	12	7	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED	351	238	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14	143	86	All SZGR 2.0 genes in this pathway
Sasson对促性腺营养蛋白DN的反应	87	66	All SZGR 2.0 genes in this pathway
Sasson对Forskolin DN的反应	88	68	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向	682	433	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway
Plasari TGFB1靶向10小时	199	143	All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN	308	187	All SZGR 2.0 genes in this pathway
Chemello Moleus vs Edl肌纤维向上	35	16	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family	目标位置			mirna id	miRNA seq
miRNA family	UTR start	UTR end	Match method	mirna id	miRNA seq
Let-7/98	163	169	1a	HSA-LET-7A^脑	UGAGGUAGUAGGUUGUAUAGUU
				HSA-LET-7B^脑	UGAGGUAGUAGGUUGUGUGGUU
				HSA-LET-7C^脑	ugagguaguagguuguaugguu
				HSA-LET-7D^脑	AGAGGUAGUAGGUUGCAUAGU
				HSA-LET-7E^脑	UGAGGUAGGAGGUUGUAUAGU
				HSA-LET-7F^脑	ugagguagauuguauauaguu
				HSA-MIR-98^脑	ugagguaaguuguauuguu
				HSA-LET-7G^SZ	ugagguaguuguuguacagu
				HSA-LET-7I^脑	UGAGGUAGUAGUUUGUGCUGU
miR-155	223	230	1a,m8	hsa-miR-155	uuaaugcuaaucgugauagggg
mir-26	214	220	1a	hsa-miR-26a^脑	Uucaaguaauccaggauaggc
mir-26	214	220	1a	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-495	171	177	1a	hsa-miR-495^脑	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhere查看与SZ相关的miRNA列表。
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.

基因页：ACTA1