Gene Page:Bard1

Summary？
基因 580
象征 Bard1
Synonyms -
Description BRCA1相关环域1
Reference MIM：601593|HGNC:HGNC:952|ENSEMBL：ENSG00000138376|HPRD：03354|Vega:OTTHUMG00000133016
基因类型 蛋白质编码
Map location 2q35
Pascal p-value 0.26
Sherlock p-value 0.701
胎儿β 1.216
主持人 Myers' cis & trans
元

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.00916
gsma_iie Genome scan meta-analysis (European-ancestry samples) Psr: 0.01016
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.3518

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS9789570 CHR2 215694649 Bard1 580 0.01 顺式
rs2166458 CHR2 215716168 Bard1 580 0 顺式
RS777307 CHR2 215731208 Bard1 580 0.18 顺式
rs7578759 CHR2 215798407 Bard1 580 0.17 顺式
RS1409612 CHR2 215800709 Bard1 580 0.03 顺式
rs2166458 CHR2 215716168 Bard1 580 0.11 反式
rs1007573 chr12 99092620 Bard1 580 0.13 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
USP40 0.79 0.82
CAPN2 0.74 0.70
SLC44A2 0.74 0.70
AK3 0.72 0.69
MCCC2 0.72 0.69
CHD1L 0.72 0.72
BMP7 0.72 0.70
ALDH7A1 0.72 0.72
CPT2 0.71 0.72
SEPT2 0.71 0.74
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
IL32 -0.40 -0.37
FAM159B -0.38 -0.26
AF347015.21 -0.36 -0.18
RP9P -0.32 -0.24
TTC9B -0.31 -0.28
CLEC3B -0.31 -0.36
AL050337.1 -0.31 -0.13
AC087071.1 -0.30 -0.13
AL049792.1 -0.29 -0.15
AC021914.1 -0.29 -0.10

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0003723 RNA结合 IDA 12419249
去：0005515 蛋白质结合 IPI 8944023|10026184|10477523
|15184379|15265711
|15782130
GO:0004842 ubiquitin-protein ligase activity nas 15905410
GO:0008270 zinc ion binding IEA -
去：0019900 kinase binding nas 15782130
GO：0042803 蛋白质同构化活性 IPI 15265711
GO:0046872 metal ion binding IEA -
GO:0046982 蛋白质异二聚化活性 IPI 15265711
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0001894 tissue homeostasis TAS 15782130
GO:0007050 cell cycle arrest nas 15632137
去：0006974 对DNA损伤刺激的反应 nas 15905410
GO:0043065 凋亡的阳性调节 IMP 15782130
GO：0016567 蛋白质泛素化 nas 15905410
GO:0043066 negative regulation of apoptosis IMP 15265711
GO：0042325 调节磷酸化 IMP 15782130
GO:0031441 negative regulation of mRNA 3'-end processing nas 15905410
GO:0045732 positive regulation of protein catabolic process nas 15905410
GO:0046826 negative regulation of protein export from nucleus IDA 15265711
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0000151 ubiquitin ligase complex nas 14976165
去：0005622 细胞内 IEA -
去：0005634 nucleus IDA 15265711
去：0005634 nucleus IMP 15632137
去：0005737 cytoplasm IDA 15265711
GO：0031436 BRCA1-BARD1 complex IDA 15265711

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
Bard1 - BRCA1相关环域1 重构的复合物 Biogrid 11257228
Bcl3 BCL4 | D19S37 B细胞CLL/淋巴瘤3 - HPRD,BioGRID 10362352
BRCA1 Brcai |BRCC1 |虹膜|PSCP |RNF53 breast cancer 1, early onset Affinity Capture-MS
亲和力捕获 - 韦斯特恩
共晶结构
共定位
共纯化
FRET
重构的复合物
Two-hybrid		 Biogrid 8944023|9342365
|9738006|9788437
|10026184|10477523
|10635334|11257228
|11278247|11301010
|11498787|11504724
|11526114|11573085
|11773071|11925436
|11927591|12431996
|12438698|12485996
|12700228|12732733
|12887909|12890688
|12951069|14636569
|14638690|14647430
|15159397|15184379
BRCA1 Brcai |BRCC1 |虹膜|PSCP |RNF53 breast cancer 1, early onset - HPRD 8944023|10026184
|11573085|11773071
|12431996
BRCA1 Brcai |BRCC1 |虹膜|PSCP |RNF53 breast cancer 1, early onset - HPRD 8944023|10026184
|11773071|12431996
BRCA2 brcc2 |FACD |时尚|Fad1 |Fancb |fancd |FANCD1 breast cancer 2, early onset 共纯化
重构的复合物		 Biogrid 14636569
BRCC3 BRCC36 |C6.1A |CXORF53 BRCA1/BRCA2-containing complex, subunit 3 Affinity Capture-MS
亲和力捕获 - 韦斯特恩		 Biogrid 14636569
布雷 BRCC4 |BRCC45 大脑和生殖器官表达（TNFRSF1A调节器） Affinity Capture-MS
亲和力捕获 - 韦斯特恩		 Biogrid 14636569
CSTF1 CstF-50 | CstFp50 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa - HPRD,BioGRID 10477523|11257228
CSTF2 CstF-64 切割刺激因子，3'Pre-RNA，亚基2，64KDA 亲和力捕获 - 韦斯特恩
共纯化		 Biogrid 10477523|11257228
E2F1 E2F-1 |RBAP1 |rbbp3 |rbp3 E2F transcription factor 1 E2F1与Bard1启动子相互作用。 绑定 11799067
E2F4 E2F-4 E2F转录因子4，P107/P130结合 E2F4与Bard1启动子区域相互作用。 绑定 11799067
ewsr1 ews Ewing sarcoma breakpoint region 1 - HPRD,BioGRID 12183411
FANCD2 DKFZP762A223 |FA-D2 |FA4 |FACD |时尚|Fad2 |fancd |FLJ23826 Fanconi贫血，互补组D2 共定位
重构的复合物		 Biogrid 12887909
H2AFX H2A.X | H2A/X | H2AX H2A histone family, member X 重构的复合物 Biogrid 11927591|12485996
Hist2H2AB - 组蛋白簇2，H2AB 重构的复合物 Biogrid 11927591
ING5 FLJ23842 | p28ING5 成长家族抑制剂，成员5 - HPRD 15383276
Med17 CRSP6 | CRSP77 | DRIP80 | FLJ10812 | TRAP80 mediator complex subunit 17 共纯化 Biogrid 12154023
MSH2 COCA1 | FCC1 | HNPCC | HNPCC1 | LCFS2 MUTS同源物2，结肠癌，非型型1型（大肠杆菌） - HPRD,BioGRID 11498787
MSH3 DUP | MGC163306 | MGC163308 | MRP1 MUTS同源物3（大肠杆菌） 重构的复合物 Biogrid 11498787
MSH6 GTBP | HNPCC5 | HSAP mutS homolog 6 (E. coli) 重构的复合物 Biogrid 11498787
nfkbiA ikba |Mad-3 |nfkbi nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Two-hybrid Biogrid 10362352
NPM1 B23 | MGC104254 | NPM nucleophosmin (nucleolar phosphoprotein B23, numatrin) Affinity Capture-MS
亲和力捕获 - 韦斯特恩
重构的复合物		 Biogrid 15184379
polr2a MGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa - HPRD 12154023
POU2F1 OCT1 | OTF1 POU class 2 homeobox 1 - HPRD 11777930
RAD51 BRCC5 |hrad51 |HSRAD51 |HST16930 |rad51a |reca RAD51homolog (RecA homolog, E. coli) (S. cerevisiae) Affinity Capture-MS
亲和力捕获 - 韦斯特恩		 Biogrid 14636569
RBBP8 ctip |轮缘 retinoblastoma binding protein 8 - HPRD,BioGRID 10764811
RELA MGC131774 |NFKB3 |P65 V-REL网状内皮症病毒性癌基因同源物A（Avian） 亲和力捕获 - 韦斯特恩 Biogrid 12700228
tcerg1 CA150 |MGC133200 |taf2s 转录伸长调节器1 - HPRD 15383276
TP53 FLJ92943 | LFS1 | TRP53 | p53 肿瘤蛋白p53 Affinity Capture-MS
亲和力捕获 - 韦斯特恩		 Biogrid 14636569
TP53 FLJ92943 | LFS1 | TRP53 | p53 肿瘤蛋白p53 TP53 (p53) interacts with BARD1. 绑定 15782130
UBA1 A1S9 |A1S9T |a1st |AMCX1 |GXP1 |MGC4781 |smax2 |Uba1a |ube1 |ube1x ubiquitin-like modifier activating enzyme 1 重构的复合物 Biogrid 11278247|11927591
|12431996|12438698
|12485996|12887909
|15184379
ube2d1 E2(17)KB1 | SFT | UBC4/5 | UBCH5 | UBCH5A ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 重构的复合物 Biogrid 11278247|11927591
|12438698|12485996
|12887909|12890688
|14636569|15184379
ube2d2 E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5B ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 重构的复合物 Biogrid 12431996
ube2d3 E2(17)KB3 | MGC43926 | MGC5416 | UBC4/5 | UBCH5C 泛素结合酶E2d 3（UBC4/5同源物，酵母） - HPRD 12732733
UBE2L3 E2-F1 | L-UBC | UBCH7 | UbcM4 泛素结合酶E2L 3 - HPRD 12732733
UBE3A ancr |AS |e6-ap |epve6ap |FLJ26981 |HPVE6A ubiquitin protein ligase E3A 重构的复合物 Biogrid 12890688
xist DKFZP779P0129 |DXS1089 |DXS399E |NCRNA00001 |SXI1 |XCE |xic |SWD66 X（非活动） - 特异性转录本（非蛋白质编码） 共定位 Biogrid 12419249
XRCC6 CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAA X射线修复补充中国仓鼠细胞中有缺陷的修复6 BARD1与XRCC6 (Ku70)。 绑定 15782130
ZHX1 - zinc fingers and homeoboxes 1 - HPRD 15383276


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
PID BARD1 PATHWAY 29 19 所有SZGR 2。0genes in this pathway
西部肾上腺皮质肿瘤标记 21 13 所有SZGR 2。0genes in this pathway
PYEON HPV POSITIVE TUMORS UP 98 47 所有SZGR 2。0genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP 146 86 所有SZGR 2。0genes in this pathway
Corre多发性骨髓瘤DN 62 41 所有SZGR 2。0genes in this pathway
vecchi胃癌早期 430 232 所有SZGR 2。0genes in this pathway
Gargalovic对氧化磷脂绿松石DN的反应 53 25 所有SZGR 2。0genes in this pathway
莱茵所有糖皮质激素治疗DN 362 238 所有SZGR 2。0genes in this pathway
Senese HDAC3靶向DN 536 332 所有SZGR 2。0genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 所有SZGR 2。0genes in this pathway
Kim WT1靶向DN 459 276 所有SZGR 2。0genes in this pathway
HAHTOLA SEZARY SYNDROM UP 98 58 所有SZGR 2。0genes in this pathway
hahtola兄弟姐妹Fungoides皮肤 177 113 所有SZGR 2。0genes in this pathway
Tang衰老TP53靶向DN 57 33 所有SZGR 2。0genes in this pathway
RIZ ERYTHROID DIFFERENTIATION HBZ 41 27 所有SZGR 2。0genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 所有SZGR 2。0genes in this pathway
Dacosta UV响应通过ERCC3公共DN 483 336 所有SZGR 2。0genes in this pathway
KIM MYCN扩增靶向DN 103 59 所有SZGR 2。0genes in this pathway
Pujana乳腺癌点燃int网络 101 73 所有SZGR 2。0genes in this pathway
PUJANA BRCA1 PCC网络 1652 1023 所有SZGR 2。0genes in this pathway
Pujana BRCA2 PCC网络 423 265 所有SZGR 2。0genes in this pathway
PUJANA CHEK2 PCC网络 779 480 所有SZGR 2。0genes in this pathway
Buytaert光动力疗法应力DN 637 377 所有SZGR 2。0genes in this pathway
狮子转移 539 324 所有SZGR 2。0genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 所有SZGR 2。0genes in this pathway
Benporath循环基因 648 385 所有SZGR 2。0genes in this pathway
Mir192和Mir215的Georges目标 893 528 所有SZGR 2。0genes in this pathway
尼尔森对雄激素DN的反应 19 14 所有SZGR 2。0genes in this pathway
彭谷氨酰胺剥夺 38 25 所有SZGR 2。0genes in this pathway
MANALO HYPOXIA DN 289 166 所有SZGR 2。0genes in this pathway
Pomeroy髓母细胞瘤预后DN 43 28 所有SZGR 2。0genes in this pathway
REN BOUND BY E2F 61 40 所有SZGR 2。0genes in this pathway
Sasaki成人T细胞白血病 176 122 所有SZGR 2。0genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI DN 73 45 所有SZGR 2。0genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 87 57 所有SZGR 2。0genes in this pathway
HADDAD B淋巴细胞祖细胞 293 193 所有SZGR 2。0genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP 70 47 所有SZGR 2。0genes in this pathway
Zhan V2晚分化基因 45 34 所有SZGR 2。0genes in this pathway
TACI DN的Moreaux多发性骨髓瘤 172 107 所有SZGR 2。0genes in this pathway
ly老龄过早的DN 30 17 所有SZGR 2。0genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2 50 34 所有SZGR 2。0genes in this pathway
KANG阿霉素耐药性 54 33 所有SZGR 2。0genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN 60 42 所有SZGR 2。0genes in this pathway
LY AGING OLD DN 56 35 所有SZGR 2。0genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 所有SZGR 2。0genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 所有SZGR 2。0genes in this pathway
由E2F4绑定的Marson未刺激 728 415 所有SZGR 2。0genes in this pathway
Sarrio上皮间质转变 180 114 所有SZGR 2。0genes in this pathway
DE YY1 TARGETS DN 92 64 所有SZGR 2。0genes in this pathway
Dairkee Cancer俯卧反应BPA E2 118 65 所有SZGR 2。0genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 所有SZGR 2。0genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 所有SZGR 2。0genes in this pathway
对Salirasib dn的Blum响应 342 220 所有SZGR 2。0genes in this pathway
FRASOR RESPONSE TO SERM OR FULVESTRANT DN 50 29 所有SZGR 2。0genes in this pathway
Ruiz TNC靶向DN 142 79 所有SZGR 2。0genes in this pathway
CHANG CYCLING GENES 148 83 所有SZGR 2。0genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G123 UP 45 21 所有SZGR 2。0genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP 178 108 所有SZGR 2。0genes in this pathway
Kobayashi EGFR信令24小时DN 251 151 所有SZGR 2。0genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 所有SZGR 2。0genes in this pathway
PYEON CANCAR CANCAR HEAD和NECK与颈椎 193 95 所有SZGR 2。0genes in this pathway
Hahtola CTCL皮肤 26 19 所有SZGR 2。0genes in this pathway
由MYC约束 1103 714 所有SZGR 2。0genes in this pathway
ZEMBUTSU SENSITIVITY TO VINCRISTINE 19 10 所有SZGR 2。0genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254 158 所有SZGR 2。0genes in this pathway
惠特菲尔德细胞周期G1 S 147 76 所有SZGR 2。0genes in this pathway
Dutertre雌二醇反应24小时 324 193 所有SZGR 2。0genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 所有SZGR 2。0genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 所有SZGR 2。0genes in this pathway