Gene Page:PEX19
概括?
| 基因 | 5824 |
| 象征 | PEX19 |
| Synonyms | D1S2223E | HK33 | PBD12A | PMP1 | PMPI | PXF | PXMP1 |
| Description | peroxisomal biogenesis factor 19 |
| Reference | MIM:600279|HGNC:HGNC:9713|Ensembl:ENSG00000162735|HPRD:02610|Vega:OTTHUMG00000033112 |
| Gene type | protein-coding |
| Map location | 1q23.2 |
| Sherlock p-value | 0.006 |
| Fetal beta | -1.145 |
| DMG | 2 (# studies) |
| eGene | 迈尔斯的顺式和跨性别 |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 2 |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | 基因组扫描荟萃分析 | Psr: 0.0235 | |
| GSMA_IIA | 基因组扫描荟萃分析(All samples) | Psr: 0.00814 | |
| 文学 | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | 点击to show details |
第一节遗传学和表观遗传学注释
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg07586906 | 1 | 160250600 | PEX19 | 1.126E-4 | 0.272 | 0.029 | DMG:Wockner_2014 |
| CG12701576 | 1 | 160254608 | PEX19 | -0.021 | 0.27 | DMG:Nishioka_2013 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| rs3766389 | chr1 | 160517213 | PEX19 | 5824 | 0.15 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| 分子功能 | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | 新闻学会 | 10704444 | |
| 生物过程 | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006625 | protein targeting to peroxisome | 小鬼 | 10704444 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005737 | 细胞质 | ISS | - | |
| GO:0005777 | peroxisome | IEA | - | |
| GO:0005777 | peroxisome | ISS | - | |
| GO:0005778 | 过氧化物酶体膜 | IDA | 9339377 | |
| 去：0016020 | 膜 | IEA | - |
第四节。蛋白质蛋白相互作用注释
| 互动者 | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| ABCD1 | ABC42 | ALD | ALDP | AMN | ATP结合盒，子家庭D（ALD），成员1 | ALDP与Farnesylated和突变型Farnesyl缺陷型PEX19相互作用。 | BIND | 10777694 |
| ABCD1 | ABC42 | ALD | ALDP | AMN | ATP结合盒，子家庭D（ALD），成员1 | - | HPRD,BioGRID | 10777694|11883941 |
| ABCD2 | ABC39 | ALDL1 | ALDR | ALDRP | hALDR | ATP结合盒，子家庭D（ALD），成员2 | - | HPRD | 10704444|10777694 |
| ABCD2 | ABC39 | ALDL1 | ALDR | ALDRP | hALDR | ATP结合盒，子家庭D（ALD），成员2 | Reconstituted Complex 两个杂交 |
BioGRID | 10777694|11883941 |
| ABCD2 | ABC39 | ALDL1 | ALDR | ALDRP | hALDR | ATP结合盒，子家庭D（ALD），成员2 | ALDRP interacts with both farnesylated and mutant farnesyl-deficient PEX19. | BIND | 10777694 |
| ABCD3 | ABC43 | PMP70 | PXMP1 | ATP结合盒，亚家族D（ALD），成员3 | PMP70 interacts with both farnesylated and mutant farnesyl-deficient PEX19. | BIND | 10777694 |
| ABCD3 | ABC43 | PMP70 | PXMP1 | ATP结合盒，亚家族D（ALD），成员3 | - | HPRD,BioGRID | 10777694|11453642 |
| PEX10 | MGC1998 | NALD | RNF69 | peroxisomal biogenesis factor 10 | PEX10 interacts with PEX19. | BIND | 12096124 |
| PEX10 | MGC1998 | NALD | RNF69 | peroxisomal biogenesis factor 10 | - | HPRD,BioGRID | 10704444 |
| PEX11A | MGC119947 | MGC138534 | PEX11-ALPHA | 过氧化物酶体生物发生因子11α | - | HPRD | 10704444 |
| PEX11B | PEX11-BETA | 过氧化物酶体生物发生因子11β | PEX11b与PEX19相互作用。 | BIND | 12096124 |
| PEX11B | PEX11-BETA | 过氧化物酶体生物发生因子11β | - | HPRD,BioGRID | 10704444 |
| PEX12 | PAF-3 | peroxisomal biogenesis factor 12 | - | HPRD,BioGRID | 10704444 |
| PEX12 | PAF-3 | peroxisomal biogenesis factor 12 | PEX12 interacts with PEX19. | BIND | 12096124 |
| PEX13 | NALD | ZWS | peroxisomal biogenesis factor 13 | PEX13 interacts with PEX19. | BIND | 12096124 |
| PEX13 | NALD | ZWS | peroxisomal biogenesis factor 13 | - | HPRD,BioGRID | 10704444 |
| PEX14 | MGC12767 |napp2 |PEX14P |DJ734G22.2 | peroxisomal biogenesis factor 14 | PEX14与PEX19相互作用。 | BIND | 12096124 |
| PEX14 | MGC12767 |napp2 |PEX14P |DJ734G22.2 | peroxisomal biogenesis factor 14 | - | HPRD,BioGRID | 10704444 |
| PEX16 | - | peroxisomal biogenesis factor 16 | PEX16 interacts with PEX19. | BIND | 12096124 |
| PEX16 | - | peroxisomal biogenesis factor 16 | - | HPRD,BioGRID | 10704444|11390669 |
| PEX3 | DKFZP686N14184 |FLJ13531 |TRG18 | 过氧化物酶体生物发生因子3 | - | HPRD,BioGRID | 10704444 |
| PEX3 | DKFZP686N14184 |FLJ13531 |TRG18 | 过氧化物酶体生物发生因子3 | PEX3interacts with PEX19. | BIND | 12096124 |
| PMP22 | CMT1A | CMT1E | DSS | GAS-3 | HMSNIA | HNPP | MGC20769 | Sp110 | peripheral myelin protein 22 | - | HPRD | 10704444 |
| PXMP4 | PMP24 | 过氧化物酶体膜protein 4, 24kDa | - | HPRD | 10704444 |
| SLC25A17 | PMP34 | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | - | HPRD,BioGRID | 10704444 |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PEROXISOME | 78 | 47 | 该途径中的所有SZGR 2.0基因 |
| REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | 18 | 11 | 该途径中的所有SZGR 2.0基因 |
| REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | 34 | 21 | 该途径中的所有SZGR 2.0基因 |
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | 该途径中的所有SZGR 2.0基因 |
| igarashi atf4靶向dn | 90 | 65 | 该途径中的所有SZGR 2.0基因 |
| Fulcher炎症反应凝集素与LPS | 579 | 346 | 该途径中的所有SZGR 2.0基因 |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | 该途径中的所有SZGR 2.0基因 |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | 该途径中的所有SZGR 2.0基因 |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | 该途径中的所有SZGR 2.0基因 |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | 该途径中的所有SZGR 2.0基因 |
| SHEN SMARCA2 TARGETS UP | 424 | 268 | 该途径中的所有SZGR 2.0基因 |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN | 546 | 351 | 该途径中的所有SZGR 2.0基因 |
| AFFAR YY1 TARGETS UP | 214 | 133 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | 该途径中的所有SZGR 2.0基因 |
| 击倒卡路里限制肌肉DN | 87 | 59 | 该途径中的所有SZGR 2.0基因 |
| BURTON ADIPOGENESIS 6 | 189 | 112 | 该途径中的所有SZGR 2.0基因 |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | 该途径中的所有SZGR 2.0基因 |
| ACEVEDO LIVER CANCER UP | 973 | 570 | 该途径中的所有SZGR 2.0基因 |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | 该途径中的所有SZGR 2.0基因 |
| CHNG MULTIPLE MYELOMA HYPERPLOID DN | 28 | 19 | 该途径中的所有SZGR 2.0基因 |
| WANG TUMOR INVASIVENESS DN | 210 | 128 | 该途径中的所有SZGR 2.0基因 |
| VANTVEER BREAST CANCER ESR1 UP | 167 | 99 | 该途径中的所有SZGR 2.0基因 |
| DANG REGULATED BY MYC DN | 253 | 192 | 该途径中的所有SZGR 2.0基因 |
| KIM ALL DISORDERS CALB1 CORR UP | 548 | 370 | 该途径中的所有SZGR 2.0基因 |
| VERHAAK GLIOBLASTOMA NEURAL | 129 | 85 | 该途径中的所有SZGR 2.0基因 |
| CHANGOLKAR H2AFY TARGETS DN | 40 | 26 | 该途径中的所有SZGR 2.0基因 |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | 该途径中的所有SZGR 2.0基因 |
Section VI. microRNA annotation
| mirna家族 | Target position | mirna id | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-183 | 135 | 142 | 1A,m8 | hsa-miR-183 | UAUGGCACUGGUAGAAUUCACUG |
| miR-205 | 259 | 265 | 1A | HSA-MIR-205 | uccuucauucccggagucug |
| miR-543 | 310 | 316 | 1A | hsa-miR-543 | AAACAUUCGCGGUGCACUUCU |