Gene Page:PYGL

Summary?
GeneID 5836
Symbol PYGL
Synonyms GSD6
Description phosphorylase, glycogen, liver
Reference MIM:613741|HGNC:HGNC:9725|Ensembl:ENSG00000100504|HPRD:01987|Vega:OTTHUMG00000166596
Gene type protein-coding
Map location 14q21-q22
Pascal p-value 0.048
Sherlock p-value 0.125
Fetal beta 0.065
DMG 1 (# studies)
eGene Myers' cis & trans
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search 系统本身arch in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg18125479 14 51411049 PYGL 1.36E-8 -0.017 5.37E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs11219646 chr11 124279239 PYGL 5836 0.05 trans
rs6598553 chr15 99339208 PYGL 5836 0.01 trans
rs2670497 chr15 99371240 PYGL 5836 0.09 trans
rs17342483 chrX 102250155 PYGL 5836 0.17 trans
rs7879274 chrX 145592957 PYGL 5836 0.04 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AGGF1 0.91 0.90
USO1 0.89 0.91
UBLCP1 0.88 0.88
MUDENG 0.88 0.87
HSPA9 0.88 0.86
VPS35 0.88 0.87
DLD 0.88 0.87
RAB18 0.88 0.86
XPOT 0.88 0.86
RPAP3 0.87 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.66 -0.47
MT-CO2 -0.63 -0.52
IFI27 -0.63 -0.54
HIGD1B -0.62 -0.52
FXYD1 -0.62 -0.52
AF347015.31 -0.59 -0.51
VAMP5 -0.58 -0.46
AF347015.2 -0.58 -0.50
AF347015.8 -0.57 -0.49
EIF4EBP3 -0.57 -0.58

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG STARCH AND SUCROSE METABOLISM 52 33 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
BIOCARTA FEEDER PATHWAY 9 8 All SZGR 2.0 genes in this pathway
REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 18 10 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247 154 All SZGR 2.0 genes in this pathway
REACTOME GLUCOSE METABOLISM 69 42 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA UP 92 57 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER CLASSES DN 34 26 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260 143 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293 179 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP 121 71 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN 200 112 All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165 100 All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244 154 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP 131 87 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA DN 41 27 All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI UP 92 58 All SZGR 2.0 genes in this pathway
PETROVA PROX1 TARGETS UP 28 16 All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS DIRECT UP 27 21 All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE DN 64 45 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C6 39 27 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220 147 All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE DN 88 42 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252 155 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS POLYSOMY7 UP 79 50 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222 141 All SZGR 2.0 genes in this pathway
MOOTHA GLYCOGEN METABOLISM 21 16 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242 159 All SZGR 2.0 genes in this pathway
国外RB1增长目标 243 155 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP 271 165 All SZGR 2.0 genes in this pathway