Gene Page:TP53INP2

Summary?
GeneID 58476
Symbol TP53INP2
Synonyms C20orf110|DOR|PINH|dJ1181N3.1
Description tumor protein p53 inducible nuclear protein 2
Reference HGNC:HGNC:16104|Ensembl:ENSG00000078804|HPRD:15546|Vega:OTTHUMG00000032310
Gene type protein-coding
Map location 20q11.22
Pascal p-value 0.03
Sherlock p-value 0.076
Fetal beta -1.451
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg26806924 20 33760017 TP53INP2 8.592E-4 -4.427 DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NDUFB11 0.91 0.89
COPE 0.90 0.89
SF3B5 0.90 0.88
C12orf57 0.90 0.88
FAU 0.89 0.91
NUBP2 0.89 0.91
TIMM17B 0.88 0.87
SCAND1 0.87 0.89
FAM96B 0.87 0.88
C6orf226 0.87 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EPB41L2 -0.55 -0.67
Z83840.4 -0.53 -0.66
SYNM -0.53 -0.63
APOL1 -0.52 -0.66
COBLL1 -0.51 -0.59
ABCB1 -0.51 -0.61
PTPRB -0.51 -0.59
PK4P -0.50 -0.58
MAP3K5 -0.49 -0.55
MYH15 -0.49 -0.62

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN 136 86 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291 176 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355 243 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164 111 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 20Q11 AMPLICON 31 18 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE DN 19 12 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
VARELA ZMPSTE24 TARGETS DN 38 18 All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS UP 100 72 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189 112 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354 216 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER DN 33 22 All SZGR 2.0 genes in this pathway
KRISHNAN FURIN TARGETS UP 12 6 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293 203 All SZGR 2.0 genes in this pathway
ELLWOOD MYC TARGETS DN 40 27 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA 43 27 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP 74 45 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP 140 81 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217 131 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1 136 76 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE UP 116 65 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway