Gene Page:ZNF462
Summary?
| GeneID | 58499 |
| Symbol | ZNF462 |
| Synonyms | Zfp462 |
| Description | zinc finger protein 462 |
| Reference | HGNC:HGNC:21684|Ensembl:ENSG00000148143|HPRD: 10333|Vega:OTTHUMG00000020438 |
| Gene type | protein-coding |
| Map location | 9q31.2 |
| Pascal p-value | 0.019 |
| Sherlock p-value | 0.37 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Putamen basal ganglia Myers' cis & trans |
| Support | Darnell FMRP targets Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10184200 | chr2 | 134561640 | ZNF462 | 58499 | 0.08 | trans | ||
| rs16829545 | chr2 | 151977407 | ZNF462 | 58499 | 0.04 | trans | ||
| rs16955618 | chr15 | 29937543 | ZNF462 | 58499 | 7.642E-4 | trans | ||
| rs57332719 | 9 | 109720491 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 95113 | gtex_brain_putamen_basal |
| rs12002021 | 9 | 109721041 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 95663 | gtex_brain_putamen_basal |
| rs11999963 | 9 | 109721364 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 95986 | gtex_brain_putamen_basal |
| rs11790439 | 9 | 109724367 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 98989 | gtex_brain_putamen_basal |
| rs10512351 | 9 | 109725918 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 100540 | gtex_brain_putamen_basal |
| rs141972169 | 9 | 109727889 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 102511 | gtex_brain_putamen_basal |
| rs11793493 | 9 | 109731124 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 105746 | gtex_brain_putamen_basal |
| rs11793958 | 9 | 109731533 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 106155 | gtex_brain_putamen_basal |
| rs16926018 | 9 | 109731844 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 106466 | gtex_brain_putamen_basal |
| rs10123849 | 9 | 109731936 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 106558 | gtex_brain_putamen_basal |
| rs140826860 | 9 | 109733116 | ZNF462 | ENSG00000148143.8 | 6.197E-7 | 0.01 | 107738 | gtex_brain_putamen_basal |
| rs113985934 | 9 | 109733120 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 107742 | gtex_brain_putamen_basal |
| rs1510285 | 9 | 109733743 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 108365 | gtex_brain_putamen_basal |
| rs55710928 | 9 | 109735229 | ZNF462 | ENSG00000148143.8 | 5.232E-7 | 0.01 | 109851 | gtex_brain_putamen_basal |
| rs12344317 | 9 | 109738406 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 113028 | gtex_brain_putamen_basal |
| rs10978689 | 9 | 109740520 | ZNF462 | ENSG00000148143.8 | 8.168E-7 | 0.01 | 115142 | gtex_brain_putamen_basal |
| rs10978691 | 9 | 109741309 | ZNF462 | ENSG00000148143.8 | 5.233 e - | 0.01 | 115931 | gtex_brain_putamen_basal |
| rs67360244 | 9 | 109741801 | ZNF462 | ENSG00000148143.8 | 5.389E-7 | 0.01 | 116423 | gtex_brain_putamen_basal |
| rs5899724 | 9 | 109741967 | ZNF462 | ENSG00000148143.8 | 5.149E-7 | 0.01 | 116589 | gtex_brain_putamen_basal |
| rs905070 | 9 | 109743287 | ZNF462 | ENSG00000148143.8 | 4.999E-7 | 0.01 | 117909 | gtex_brain_putamen_basal |
| rs905071 | 9 | 109743427 | ZNF462 | ENSG00000148143.8 | 4.977E-7 | 0.01 | 118049 | gtex_brain_putamen_basal |
| rs7049113 | 9 | 109745208 | ZNF462 | ENSG00000148143.8 | 4.774E-7 | 0.01 | 119830 | gtex_brain_putamen_basal |
| rs68037703 | 9 | 109746947 | ZNF462 | ENSG00000148143.8 | 4.618E-7 | 0.01 | 121569 | gtex_brain_putamen_basal |
| rs12553031 | 9 | 109752583 | ZNF462 | ENSG00000148143.8 | 4.47E-7 | 0.01 | 127205 | gtex_brain_putamen_basal |
| rs67393007 | 9 | 109755104 | ZNF462 | ENSG00000148143.8 | 4.423E-7 | 0.01 | 129726 | gtex_brain_putamen_basal |
| rs72743712 | 9 | 109755320 | ZNF462 | ENSG00000148143.8 | 4.404E-7 | 0.01 | 129942 | gtex_brain_putamen_basal |
| rs7043107 | 9 | 109755972 | ZNF462 | ENSG00000148143.8 | 4.357E-7 | 0.01 | 130594 | gtex_brain_putamen_basal |
| rs10978697 | 9 | 109763587 | ZNF462 | ENSG00000148143.8 | 1.225E-6 | 0.01 | 138209 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CDK9 | 0.83 | 0.81 |
| THOC5 | 0.82 | 0.81 |
| INTS3 | 0.81 | 0.81 |
| WDR59 | 0.80 | 0.81 |
| DDX27 | 0.80 | 0.80 |
| SUPT7L | 0.80 | 0.79 |
| C1orf174 | 0.80 | 0.82 |
| COG7 | 0.80 | 0.79 |
| MSTO1 | 0.80 | 0.81 |
| IQCC | 0.80 | 0.80 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.70 | -0.66 |
| MT-CO2 | -0.70 | -0.65 |
| AF347015.21 | -0.69 | -0.68 |
| AF347015.8 | -0.68 | -0.65 |
| MT-CYB | -0.68 | -0.63 |
| AF347015.27 | -0.67 | -0.64 |
| AF347015.2 | -0.66 | -0.62 |
| AF347015.33 | -0.65 | -0.61 |
| AF347015.15 | -0.64 | -0.63 |
| HIGD1B | -0.62 | -0.62 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN | 198 | 110 | All SZGR 2.0 genes in this pathway |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE DN | 61 | 35 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 1 UP | 121 | 71 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 6HR DN | 514 | 330 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX4 DN | 32 | 22 | All SZGR 2.0 genes in this pathway |
| MOLENAAR TARGETS OF CCND1 AND CDK4 UP | 67 | 48 | All SZGR 2.0 genes in this pathway |
| 阿塞维多甲基化我N LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |
| ZHOU CELL CYCLE GENES IN IR RESPONSE 2HR | 8 | 5 | All SZGR 2.0 genes in this pathway |