Gene Page:RAB27A

Summary?
GeneID 5873
Symbol RAB27A
Synonyms GS2|HsT18676|RAB27|RAM
Description RAB27A, member RAS oncogene family
Reference MIM:603868|HGNC:HGNC:9766|Ensembl:ENSG00000069974|HPRD:04845|Vega:OTTHUMG00000131959
Gene type protein-coding
Map location 15q21.3
Pascal p-value 0.005
DEG p-value DEG:Sanders_2014:DS1_p=0.142:DS1_beta=0.042400:DS2_p=2.18e-02:DS2_beta=0.114:DS2_FDR=1.20e-01
Fetal beta 0.054
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Cerebellum
Cortex
Nucleus accumbens basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DEG:Sanders_2013 Microarray Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06032813 15 55582570 RAB27A 4.26E-8 0.016 1.18E-5 DMG:Jaffe_2016
cg15345126 15 55582248 RAB27A 6.61E-8 0.01 1.63E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PNPLA6 0.90 0.88
DCTN1 0.90 0.89
ABCF3 0.90 0.88
OTUD5 0.89 0.89
CACNB1 0.88 0.87
ENO2 0.88 0.88
MAPK8IP3 0.88 0.86
C17orf28 0.88 0.85
APLP1 0.88 0.88
ADRBK1 0.88 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 0.68 0.52
AF347015.31 0.59 0.47
MT-CO2 0.59 0.46
GNG11 0.59 0.49
AF347015.8 0.58 0.45
C1orf54 0.58 0.51
AP002478.3 0.57 0.50
NOSTRIN 0.56 0.44
AF347015.2 0.56 0.39
AF347015.18 0.56 0.42

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
走:0000166 nucleotide binding IEA -
走:0003924 GTPase activity TAS 9066979
走:0005515 protein binding IEA -
走:0005525 GTP binding IEA -
走:0031489 myosin V binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
走:0007596 blood coagulation IEA -
去:0007264 small GTPase mediated signal transduction IEA -
走:0006605 protein targeting IEA -
走:0016192 vesicle-mediated transport IEA -
走:0015031 protein transport IEA -
走:0043473 pigmentation IEA -
走:0032402 melanosome transport IEA -
走:0032400 melanosome localization IEA -
走:0030318 melanocyte differentiation IEA -
走:0043320 natural killer cell degranulation IEA -
走:0043316 cytotoxic T cell degranulation IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
走:0030425 dendrite IDA neuron, axon, dendrite (GO term level: 6) 11266474
走:0001750 photoreceptor outer segment IEA -
走:0005794 Golgi apparatus IEA -
走:0005737 cytoplasm IDA 18029348
走:0016020 membrane IEA -
走:0042470 melanosome IDA 11266474
走:0030141 secretory granule IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
C14orf1 ERG28 | NET51 chromosome 14 open reading frame 1 Two-hybrid BioGRID 16169070
C1orf103 FLJ11269 | RIF1 | RP11-96K19.1 chromosome 1 open reading frame 103 Two-hybrid BioGRID 16169070
C7orf64 DKFZP564O0523 | DKFZp686D1651 | HSPC304 chromosome 7 open reading frame 64 Two-hybrid BioGRID 16169070
COPS6 CSN6 | MOV34-34KD COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) Two-hybrid BioGRID 16169070
EEF1A1 CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1 eukaryotic translation elongation factor 1 alpha 1 Two-hybrid BioGRID 16169070
EXPH5 DKFZp781H0795 | KIAA0624 | MGC133291 | MGC134967 | SLAC2-B exophilin 5 Affinity Capture-Western BioGRID 11773082
GDF9 - growth differentiation factor 9 Two-hybrid BioGRID 16169070
GZMB CCPI | CGL-1 | CGL1 | CSP-B | CSPB | CTLA1 | CTSGL1 | HLP | SECT granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) - HPRD 11266473
KIAA1377 - KIAA1377 Two-hybrid BioGRID 16169070
MLPH MGC2771 | MGC59733 | SLAC2-A melanophilin - HPRD 11773082|11856727
|11980908|12062444
|15059972
MLPH MGC2771 | MGC59733 | SLAC2-A melanophilin Affinity Capture-Western
Reconstituted Complex
Two-hybrid		 BioGRID 11773082|11980908
|12062444|15059972
MYO5A GS1 | MYH12 | MYO5 | MYR12 myosin VA (heavy chain 12, myoxin) - HPRD,BioGRID 12006666
MYRIP DKFZp586F1018 | FLJ44025 | MGC130034 | MGC130035 | SLAC2-C | SLAC2C myosin VIIA and Rab interacting protein - HPRD,BioGRID 12590134
RPH3A KIAA0985 rabphilin 3A homolog (mouse) Affinity Capture-Western BioGRID 12578829
RPH3AL NOC2 rabphilin 3A-like (without C2 domains) - HPRD,BioGRID 12578829
STX1A HPC-1 | STX1 | p35-1 syntaxin 1A (brain) - HPRD 12101244
SYTL1 FLJ14996 | JFC1 | SLP1 synaptotagmin-like 1 - HPRD,BioGRID 11980908
SYTL1 FLJ14996 | JFC1 | SLP1 synaptotagmin-like 1 - HPRD 12590134
SYTL2 CHR11SYT | KIAA1597 | MGC102768 | SGA72M | SLP2 synaptotagmin-like 2 - HPRD 11773082|12590134
SYTL2 CHR11SYT | KIAA1597 | MGC102768 | SGA72M | SLP2 synaptotagmin-like 2 - HPRD,BioGRID 11773082
SYTL3 MGC105130 | MGC118883 | MGC118884 | MGC118885 | SLP3 synaptotagmin-like 3 - HPRD,BioGRID 11773082|12590134
SYTL4 DKFZp451P0116 | FLJ40960 | SLP4 synaptotagmin-like 4 - HPRD 11773082|11865063
SYTL4 DKFZp451P0116 | FLJ40960 | SLP4 synaptotagmin-like 4 Affinity Capture-Western
Reconstituted Complex
Two-hybrid		 BioGRID 11773082|11865063
|12101244|12176990
|12590134
SYTL5 slp5 synaptotagmin-like 5 - HPRD,BioGRID 12051743
UNC13D FHL3 | HLH3 | HPLH3 | Munc13-4 unc-13 homolog D (C. elegans) Reconstituted Complex BioGRID 14699162
ZBTB16 PLZF | ZNF145 zinc finger and BTB domain containing 16 Two-hybrid BioGRID 16169070


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA RAB PATHWAY 12 8 All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 133 91 All SZGR 2.0 genes in this pathway
REACTOME INSULIN SYNTHESIS AND PROCESSING 21 15 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198 110 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS DN 62 35 All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320 184 All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS UP 81 40 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367 220 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
BARRIER CANCER RELAPSE NORMAL SAMPLE UP 32 21 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
WANG PROSTATE CANCER ANDROGEN INDEPENDENT 66 37 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 87 58 All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION 101 66 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS UP 52 34 All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN 234 137 All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP 70 47 All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP 101 76 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN 60 42 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 148 96 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
ZHANG GATA6 TARGETS DN 64 46 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
马丁内斯RB1和TP53的目标 601 369 All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP 125 68 All SZGR 2.0 genes in this pathway
PARK APL PATHOGENESIS DN 50 35 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A4 196 124 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G6 DN 19 13 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G56 DN 17 9 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN 170 105 All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION DN 20 12 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 91 59 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 90 58 All SZGR 2.0 genes in this pathway
KAMIKUBO MYELOID MN1 NETWORK 19 14 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS LOW SERUM 100 51 All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS UP 44 30 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387 225 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229 135 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 135 96 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 338 345 1A,m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 338 344 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC