SZGR2 - Beplay体育中心

Summary?

基因	5879
Symbol	Rac1
同义词	MIG5 \| RAC-1 \| TC-25 \| P21-RAC1
描述	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
参考	MIM：602048\|HGNC：HGNC：9801\|ENSEMBL：ENSG00000136238\|HPRD：03627\|Vega：Otthumg0000000023540
基因type	protein-coding
地图位置	7p22
Pascal P值	0.705
Sherlock P值	0.56
Fetal beta	-0.426
DMG	1（＃研究）
eGene	Cerebellum
支持	细胞内信号转导 G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-CONSESUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_TAP-PSD-95-CORE G2Cdb.humanNRC g2cdb.humanpsd G2CDB.HUMANPSP CompositeSet Potential synaptic genes

基因in Data Sources

基因set name	基因组方法	描述	Info
简历：PGCNP	全基因组协会研究	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	高通量文献搜索	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学	高通量文献搜索	与精神分裂症关键词共同存在：精神分裂症，精神分裂症	Click to show details
网络	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.2217

Section I. Genetics and epigenetics annotation

差异甲基化基因

探测	Chromosome	Position	最近的基因	P (dis)	beta（dis）	FDR (dis)	Study
cg15381475	7	6436101	Rac1	1.34E-4	0.506	0.031	DMG:Wockner_2014

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
SPIRE1	0.91	0.95
SLAIN2	0.90	0.91
Nell2	0.89	0.88
RLBP1L1	0.89	0.89
NCOA2	0.89	0.94
ACVR1B	0.89	0.93
LASS6	0.88	0.93
KBTBD7	0.88	0.93
HERC3	0.88	0.92
ZNF238	0.88	0.89

前10个负共表达基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
FXYD1	-0.67	-0.84
SERPINB6	-0.65	-0.72
HSD17B14	-0.64	-0.76
MT-CO2	-0.64	-0.82
AF347015.31	-0.64	-0.80
S100B	-0.62	-0.77
AF347015.33	-0.62	-0.77
TSC22D4	-0.62	-0.73
HEPN1	-0.62	-0.71
AIFM3	-0.62	-0.71

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0000166	核苷酸结合	IEA		-
去：0003924	GTPase activity	塔斯		9312003
GO:0005525	GTP结合	IEA		-
GO：0019899	enzyme binding	IPI		16636067
GO:0030742	GTP-dependent蛋白结合	IPI		10954424
Biological process	去的术语	Evidence	Neuro keywords	PubMed ID
去：0007155	细胞粘附	塔斯		9572733
去：0009653	anatomical structure morphogenesis	塔斯		9572733
GO：0010310	regulation of hydrogen peroxide metabolic process	塔斯		16636067
GO:0006954	炎症反应	塔斯		9572733
去：0006928	细胞运动	塔斯		9572733
去：0007264	small GTPase mediated signal transduction	IEA		-
GO:0035025	positive regulation of Rho protein signal transduction	塔斯		9312003
GO：0031529	ruffle organization	塔斯		9312003
GO:0048261	negative regulation of receptor-mediated endocytosis	塔斯		9312003
GO：0030041	肌动蛋白丝聚合	塔斯		9312003
去：0030032	lamellipodium biogenesis	小鬼		9312003
GO:0051668	localization within membrane	小鬼		16636067
GO:0060263	呼吸爆发调节	艾达		16636067
细胞分量	去的术语	Evidence	Neuro keywords	PubMed ID
去：0005829	cytosol	经验		7744773\|10648409\|14737186
GO:0005622	intracellular	IEA		-
GO:0005886	质膜	IEA		-
GO：0042470	黑色素体	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
acta1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	肌动蛋白，α1，骨骼肌	-	HPRD	11027608
动作	PS1TP5BP1	肌动蛋白,β	-	HPRD，Biogrid	11027608
arfip2	POR1	ADP-核糖基化因子相互作用蛋白2	Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	8670882\|11346801 \|11478794
arfip2	POR1	ADP-核糖基化因子相互作用蛋白2	-	HPRD	8670882\|11478794
ARHGAP15	BM046	Rho GTPase激活蛋白15	-	HPRD，Biogrid	12650940
ARHGAP17	DKFZP564A1363 \|FLJ37567 \|FLJ43368 \|MGC87805 \|MST066 \|MST110 \|MSTP038 \|MSTP066 \|MSTP110 \|纳德林\| RICH1 \| WBP15	Rho GTPase激活蛋白17	Biochemical Activity	BioGRID	11431473
ARHGAP27	CAMGAP1 \|FLJ43547 \|MGC120624	Rho GTPase activating protein 27	Biochemical Activity	BioGRID	15147912
ARHGAP8	BPGAP1 \|FLJ20185 \|PP610	Rho GTPase activating protein 8	BPGAP1 interacts with Rac1.	BIND	12944407
Arhgdia	GDIA1 \|MGC117248 \|Rhogdi \|Rhogdi-1	Rho GDP dissociation inhibitor (GDI) alpha	-	HPRD	10346909\|10673424 \| 11513579
Arhgdia	GDIA1 \|MGC117248 \|Rhogdi \|Rhogdi-1	Rho GDP dissociation inhibitor (GDI) alpha	-	HPRD，Biogrid	10673424
Arhgdib	D4 \| GDIA2 \| GDID4 \| LYGDI \| Ly-GDI \| RAP1GN1 \| RhoGDI2	RHO GDP解离抑制剂（GDI）β	-	HPRD，Biogrid	9799233
Arhgdig	RHOGDI-3	Rho GDP dissociation inhibitor (GDI) gamma	Rac1与Rhogdi互动。	BIND	14764880
Arhgef2	DKFZP547L106 \|DKFZP547P1516 \|GEF \|GEF-H1 \|gefh1 \|KIAA0651 \|LFP40 \|P40	Rho/RAC鸟嘌呤核苷酸交换因子（GEF）2	-	HPRD，Biogrid	9857026\|11595749
Arhgef4	ASEF \|ASEF1 \|gef4 \|STM6	Rho鸟嘌呤核苷酸交换因子（GEF）4	Reconstituted Complex	BioGRID	10947987
Arhgef6	COOL2 \| Cool-2 \| KIAA0006 \| MRX46 \| PIXA \| alpha-PIX \| alphaPIX	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	ARHGEF6（Cool-2）与Rac1相互作用。	BIND	15649357
BAIAP2	bap2 \|IRSP53	BAI1-associated protein 2	-	HPRD，Biogrid	11130076\|12054568
CDC42	cdc42hs \|G25K	细胞分裂周期42（GTP结合蛋白，25KDA）	Two-hybrid	BioGRID	9427749
cdc42bpg	DMPK2 \| HSMDPKIN \| KAPPA-200 \| MRCKgamma	Cdc42结合蛋白激酶γ（类似DMPK）	-	HPRD，Biogrid	15194684
CDC42SE1	SCIP1 \| SPEC1	CDC42小效应器1	-	HPRD，Biogrid	10816584
CDC42SE2	FLJ21967 \| SPEC2	CDC42小效应器2	Two-hybrid	BioGRID	10816584
CDGAP	KIAA1204 \| MGC138368 \| MGC138370	Cdc42 GTPase-activating protein	-	HPRD	9786927
CHN1	ARHGAP2 \| CHN \| DURS2 \| RHOGAP2	chimerin (chimaerin) 1	-	HPRD	8496137
CIT	克里克\|KIAA0949 \|STK21	Citron（Rho Interacting，丝氨酸/苏氨酸激酶21）	远西方	BioGRID	8543060
CLIP1	剪辑\|夹170 \|夹170 \|cyln1 \|MGC131604 \|RSN	CAP-GLY domain containing linker protein 1	Affinity Capture-Western	BioGRID	12110184
Cyba	p22-PHOX	cytochrome b-245, alpha polypeptide	-	HPRD	10486263
CYFIP1	FLJ45151 \| P140SRA-1 \| SHYC \| SRA1	细胞质FMR1相互作用蛋白1	-	HPRD	9417078
DEF6	IBP \| SLAT	differentially expressed in FDCP 6 homolog (mouse)	-	HPRD，Biogrid	15023524
DEF6	IBP \| SLAT	differentially expressed in FDCP 6 homolog (mouse)	DEF6与Rac1相互作用。这种相互作用是基于未指定物种的人类Def6和Rac1之间的相互作用进行建模的。	BIND	15023524
diaph1	DFNA1 \|dia1 \|drf1 \|FLJ25265 \|lfhl1 \|HDIA1	diaphanous homolog 1 (Drosophila)	-	HPRD	11590143
DMPK	DM \|DM1 \|DM1PK \|DMK \|MDPK \|MT-PK	营养不良肌蛋白蛋白激酶	Reconstituted Complex	BioGRID	10869570
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	Rac interacts with Dock180.	BIND	12134158
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	-	HPRD，Biogrid	9808620
DOCK2	FLJ46592 \| KIAA0209	dedicator of cytokinesis 2	-	HPRD，Biogrid	10559471
DOCK8	FLJ00026 \|FLJ00152 \|FLJ00346 \|MRD2 \|ZIR8	dedicator of cytokinesis 8	-	HPRD，Biogrid	15304341
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	-	HPRD	7738010
FHOD1	FHOS	formin同源性2包含1个域	-	HPRD，Biogrid	11590143
FLNA	ABP-280 \|ABPX \|DKFZP434P031 \|fln \|fln1 \|FMD \|MNS \|NHBP \|OPD \|OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD	10051605
FMNL1	C17orf1 \|C17orf1b \|FHOD4 \|fmnl \|KW-13 \|MGC133052 \|MGC1894 \|MGC21878	类似于形式的1	-	HPRD，Biogrid	10958683
geft	p63rhogef	RhoA/RAC/CDC42 exchange factor	-	HPRD，Biogrid	12547822
ICMT	HSTE14 \| MGC39955 \| MST098 \| MSTP098 \| PCCMT \| PCMT \| PPMT	isoprenylcysteine carboxyl methyltransferase	-	HPRD，Biogrid	12006387
IL1RAP	C3orf13 \| FLJ37788 \| IL-1RAcP \| IL1R3	白介素1受体配件蛋白	-	HPRD，Biogrid	11416133
IQGAP1	humorfa01 \|KIAA0051 \|sar1 \|P195	IQ motif containing GTPase activating protein 1	-	HPRD，Biogrid	8670801
IQGAP2	-	IQ motif containing GTPase activating protein 2	-	HPRD，Biogrid	8702968\|8756646 \| 8756646
IQGAP2	-	IQ motif containing GTPase activating protein 2	-	HPRD	8756646
KTN1	CG1 \| KIAA0004 \| KNT \| MGC133337 \| MU-RMS-40.19	动力蛋白1（动力素受体）	-	HPRD，Biogrid	8769096
MAP3K10	MLK2 \|MST	有丝分裂原激活的蛋白激酶激酶激酶10	Reconstituted Complex	BioGRID	9427749
MAP3K11	MGC17114 \|MLK-3 \|MLK3 \|ptk1 \|泉水	有丝分裂原激活的蛋白激酶激酶激酶11	-	HPRD	9427749
MAP3K4	FLJ42439 \| KIAA0213 \| MAPKKK4 \| MEKK4 \| MTK1 \| PRO0412	mitogen-activated protein kinase kinase kinase 4	Reconstituted Complex	BioGRID	9079650
MCF2L	Arhgef14 \|DBS \|FLJ12122 \|KIAA0362 \|Ost	MCF.2细胞系导出的转化序列样	-	HPRD，Biogrid	7957046\|14701795
METAP2	MAP2 \| MNPEP \| p67 \| p67eIF2	甲基氨基肽酶2	-	HPRD	7738010
MYD88	myd88d	myeloid differentiation primary response gene (88)	Affinity Capture-Western Reconstituted Complex	BioGRID	11416133
NCF1C	SH3PXD1C	neutrophil cytosolic factor 1C pseudogene	-	HPRD	9255350
NCF2	FLJ93058 \| NCF-2 \| NOXA2 \| P67-PHOX \| P67PHOX	neutrophil cytosolic factor 2	-	HPRD	9255350\|9624165 \|11896062 \| 11090627
NCF2	FLJ93058 \| NCF-2 \| NOXA2 \| P67-PHOX \| P67PHOX	neutrophil cytosolic factor 2	-	HPRD	7738010\|8036496 \|9255350\|9624165 \|11090627\|11896062 \| 11090627
NCF2	FLJ93058 \| NCF-2 \| NOXA2 \| P67-PHOX \| P67PHOX	neutrophil cytosolic factor 2	Co-crystal Structure Reconstituted Complex	BioGRID	9624165\|9642115 \|11090627
NCK1	MGC12668 \| NCK \| NCKalpha	NCK适配器蛋白1	-	HPRD	10766742
NCKAP1	FLJ11291 \| HEM2 \| KIAA0587 \| MGC8981 \| NAP1 \| NAP125	NCK-associated protein 1	-	HPRD	9148763\|9417078
NCKAP1	FLJ11291 \| HEM2 \| KIAA0587 \| MGC8981 \| NAP1 \| NAP125	NCK-associated protein 1	-	HPRD，Biogrid	9148763
NOS2	hep-nos \|iNos \|nos \|NOS2A	nitric oxide synthase 2, inducible	-	HPRD	11422783\|11457725
NOS2	hep-nos \|iNos \|nos \|NOS2A	nitric oxide synthase 2, inducible	-	HPRD，Biogrid	11457725
NOXA1	FLJ25475 \| MGC131800 \| NY-CO-31 \| SDCCAG31 \| p51NOX	NADPH氧化酶激活剂1	-	HPRD	12716910
OPHN1	MRX60 \|OPN1	oligophrenin 1	-	HPRD，Biogrid	9582072\|11998687
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	PAK1与RAC的未指定同工型相互作用。这种相互作用是基于中国仓鼠的人类PAK1与RAC之间的相互作用建模的。	BIND	15975516
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	PAK1与RAC的未指定同工型相互作用。This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Rac.	BIND	15864311
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD	7744004\|8107774 \|11134022\|11950930\|11134022
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	Reconstituted Complex	BioGRID	12650940\|12879077
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	活跃的GTP结合Rac1与PAK1B相互作用。这种相互作用是建立在鸡肉Rac1和人PAK1B之间的相互作用的模型的。	BIND	15735674
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	Rac1与PAK1相互作用。这种相互作用是基于未指定物种的Rac1和Pak1之间的相互作用进行建模的。	BIND	15652748
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	Rac1与PAK1相互作用。This interaction was modelled on a demonstrated interacton between Rac1 from an unspecified species and human Pak1.	BIND	12944407
PAK2	PAK65 \| PAKgamma	p21 protein (Cdc42/Rac)-activated kinase 2	-	HPRD，Biogrid	9535855
PAK3	CDKN1A \|MRX30 \|MRX47 \|OPHN3 \|pak3beta \|bpak \|HPAK3	p21 protein (Cdc42/Rac)-activated kinase 3	Reconstituted Complex Two-hybrid	BioGRID	11478794
PAK4	-	p21 protein (Cdc42/Rac)-activated kinase 4	Affinity Capture-Western	BioGRID	11756552
PAK7	KIAA1264 \|MGC26232 \|PAK5	p21 protein (Cdc42/Rac)-activated kinase 7	-	HPRD，Biogrid	11756552
PARD6A	Par-6a \|PAR6 \|PAR6C \|par6alpha \|税务40 \|提示40	PAR-6分区有缺陷的6个同源α（C.秀丽隐杆线）	-	HPRD，Biogrid	11260256
PARD6G	FLJ45701 \| PAR-6G \| PAR6gamma	par-6 partitioning defective 6 homolog gamma (C. elegans)	-	HPRD，Biogrid	11260256
PARK2	AR-JP \| LPRS2 \| PDJ \| PRKN	Parkinson disease (autosomal recessive, juvenile) 2, parkin	Two-hybrid	BioGRID	16169070
PIK3R1	grb1 \|P85 \|p85-alpha	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	7629060\|8034624 \|12086876
PIK3R1	grb1 \|P85 \|p85-alpha	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	12086876
PLD1	-	phospholipase D1, phosphatidylcholine-specific	-	HPRD	11950936
PLEKHG2	clg \|DKFZP667J2325 \|FLJ00018 \|FLJ22458 \|FLJ38638	pleckstrin同源域包含家庭G (with RhoGef domain) member 2	-	HPRD，Biogrid	11839748
PLXNB1	KIAA0407 \|MGC149167 \|plexin-b1 \|PLXN5 \|九月	plexin B1	-	HPRD	12123608
PLXNB1	KIAA0407 \|MGC149167 \|plexin-b1 \|PLXN5 \|九月	plexin B1	Plexin-B1与Rac1相互作用。这种相互作用是基于未指定物种的人类Plexin-B1与Rac1之间的相互作用进行建模的。	BIND	15642257
PRKCA	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	蛋白激酶C，α	-	HPRD，Biogrid	11284700
Ptplad1	B-IND1 \| FLJ90376 \| HSPC121	蛋白酪氨酸磷酸酶类似于1个结构域	-	HPRD，Biogrid	10747961
Rac1	MGC111543 \|Mig5 \|TC-25 \|P21-RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	Reconstituted Complex	BioGRID	11134022
ralbp1	RIP1 \|rlip1 \|rlip76	ralA binding protein 1	Rac1与RLIP76相互作用。	BIND	7673236
ralbp1	RIP1 \|rlip1 \|rlip76	ralA binding protein 1	-	HPRD，Biogrid	7673236
RAP1GDS1	GDS1 \| MGC118859 \| MGC118861 \| SmgGDS	RAP1，GTP-GDP解离刺激器1	-	HPRD，Biogrid	11948427
RCC2	DKFZp762N0610 \| KIAA1470 \| TD-60	regulator of chromosome condensation 2	-	HPRD	12919680
RGL2	HKE1.5 \|ke1.5 \|rab2l	拉尔鸟嘌呤核苷酸解离刺激器样2	Two-hybrid	BioGRID	8939933
Rich2	KIAA0672 \|NPC-A-10	Rho-type GTPase-activating protein RICH2	Biochemical Activity	BioGRID	11431473
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	Biochemical Activity	BioGRID	12454018\|12819203
RPS6KB1	PS6K \| S6K \| S6K1 \| STK14A \| p70(S6K)-alpha \| p70-S6K \| p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	-	HPRD	11438723
SH3BP1	-	SH3膜结合蛋白1	-	HPRD	10508610
STAT3	APRF \|FLJ20882 \|hies \|MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	-	HPRD，Biogrid	11021801
SYNJ2	INPP5H \| KIAA0348 \| MGC44422	synaptojanin 2	-	HPRD，Biogrid	11084340
TBC1D3	TBC1D3A \| TRE17	TBC1域家庭，成员3	-	HPRD，Biogrid	12612085
TCF7L2	TCF-4 \| TCF4	transcription factor 7-like 2 (T-cell specific, HMG-box)	Rac1与TCF4相互作用。	BIND	15377999
TEC	MGC126760 \|MGC126762 \|PSCTK4	TEC蛋白酪氨酸激酶	表型增强	BioGRID	11328862
提亚姆1	FLJ36302	T-cell lymphoma invasion and metastasis 1	GTPase RAC1与核苷酸交换因子TIAM1的DBL - 同源结构域特异性相互作用。这种相互作用是建立在小鼠tiam1和人rac1之间的相互作用上的模型。	BIND	11130063
提亚姆1	FLJ36302	T-cell lymphoma invasion and metastasis 1	-	HPRD，Biogrid	11130063\|11595749
TNFRSF12A	CD266 \| FN14 \| TWEAKR	肿瘤坏死因子受体超家族，成员12a	-	HPRD	14573547
TNFRSF12A	CD266 \| FN14 \| TWEAKR	肿瘤坏死因子受体超家族，成员12a	FN14与Rac1相互作用。	BIND	14573547
TRIO	FLJ42780 \| tgat	三重功能域（PTPRF相互作用）	-	HPRD，Biogrid	11595749
TUBA4A	FLJ30169 \| H2-ALPHA \| TUBA1	微管蛋白，α4A	-	HPRD	8631991
vav1	VAV	VAV 1鸟嘌呤核苷酸交换因子	Affinity Capture-Western	BioGRID	11287617
vav3	FLJ40431	VAV 3鸟嘌呤核苷酸交换因子	-	HPRD，Biogrid	10523675
曾是	IMD2 \|THC \|黄蜂	Wiskott-Aldrich综合征（湿疹 - 肉毒细胞减少症）	-	HPRD，Biogrid	8643625
WASF1	FLJ31482 \|KIAA0269 \|Scar1 \|波\|Wave1	是蛋白质家族，成员1	-	HPRD	9843499

V.途径注释

Pathway name	Pathway size	＃szgr 2.0基因	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
kegg wnt信号通路	151	112	All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE	129	103	All SZGR 2.0 genes in this pathway
kegg vegf信号通路	76	53	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
kegg粘附交界处	75	53	All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	102	88	All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY	137	92	All SZGR 2.0 genes in this pathway
KEGG B细胞受体信号通路	75	56	All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY	79	58	All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS	97	71	All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION	118	78	All SZGR 2.0 genes in this pathway
KEGG神经营养蛋白信号传导途径	126	103	All SZGR 2.0 genes in this pathway
肌动蛋白细胞骨架的KEGG调节	216	144	All SZGR 2.0 genes in this pathway
KEGG肌萎缩性侧索硬化症ALS	53	43	All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION	68	44	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER	62	47	All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA	70	60	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG病毒心肌炎	73	58	All SZGR 2.0 genes in this pathway
Biocarta AGR途径	36	31	All SZGR 2.0 genes in this pathway
Biocarta AT1R途径	36	28	All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY	37	28	All SZGR 2.0 genes in this pathway
Biocarta FMLP途径	39	29	All SZGR 2.0 genes in this pathway
BIOCARTA SALMONELLA PATHWAY	13	10	All SZGR 2.0 genes in this pathway
Biocarta RaccyCD途径	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
Biocarta MAPK途径	87	68	All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY	40	31	All SZGR 2.0 genes in this pathway
BIOCARTA PTDINS PATHWAY	23	16	All SZGR 2.0 genes in this pathway
BIOCARTA EDG1 PATHWAY	27	24	All SZGR 2.0 genes in this pathway
BIOCARTA RAC1 PATHWAY	23	16	All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY	23	20	All SZGR 2.0 genes in this pathway
Biocarta nkcells途径	20	13	All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY	19	17	All SZGR 2.0 genes in this pathway
BIOCARTA CDC42RAC PATHWAY	16	13	All SZGR 2.0 genes in this pathway
Biocarta TCR途径	49	37	All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY	27	25	All SZGR 2.0 genes in this pathway
Biocarta ARF途径	17	13	All SZGR 2.0 genes in this pathway
BIOCARTA UCALPAIN PATHWAY	18	11	All SZGR 2.0 genes in this pathway
BIOCARTA ACTINY PATHWAY	20	14	All SZGR 2.0 genes in this pathway
SA B CELL RECEPTOR COMPLEXES	24	20	All SZGR 2.0 genes in this pathway
St Myocyte广告路径	27	25	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID BCR 5 Pathway	65	50	All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY	23	17	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID P38 MKK3 6 Pathway	26	21	All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY	32	26	All SZGR 2.0 genes in this pathway
PID遇到了路径	80	60	All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY	29	24	All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY	40	38	All SZGR 2.0 genes in this pathway
PID AVB3 OPN途径	31	29	All SZGR 2.0 genes in this pathway
PID ILK PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID NECTIN PATHWAY	30	20	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY	31	25	All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY	70	51	All SZGR 2.0 genes in this pathway
PID RET PATHWAY	39	29	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID TXA2 Pathway	57	43	All SZGR 2.0 genes in this pathway
PID S1P S1P1途径	21	18	All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY	32	27	All SZGR 2.0 genes in this pathway
PID整合素A9B1途径	25	18	All SZGR 2.0 genes in this pathway
PID ARF6下游途径	15	14	All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY	69	55	All SZGR 2.0 genes in this pathway
PID CXCR4途径	102	78	All SZGR 2.0 genes in this pathway
PID PI3KCI途径	49	40	All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY	48	38	All SZGR 2.0 genes in this pathway
PID IL2 PI3K PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY	69	51	All SZGR 2.0 genes in this pathway
PID Ecadherin新生AJ途径	39	33	All SZGR 2.0 genes in this pathway
PID AVB3整合素途径	75	53	All SZGR 2.0 genes in this pathway
PID LIS1 PATHWAY	28	22	All SZGR 2.0 genes in this pathway
PID ERBB1下游途径	105	78	All SZGR 2.0 genes in this pathway
PID SYNDECAN 4 PATHWAY	32	25	All SZGR 2.0 genes in this pathway
pid upa upar途径	42	30	All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3途径	44	35	All SZGR 2.0 genes in this pathway
PID IL6 7途径	47	40	All SZGR 2.0 genes in this pathway
PID ECADHERIN KERATINOCYTE PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID PDGFRB途径	129	103	All SZGR 2.0 genes in this pathway
PID TRKR途径	62	48	All SZGR 2.0 genes in this pathway
PID肾素Neph1途径	31	24	All SZGR 2.0 genes in this pathway
pid ar nongenomic途径	31	27	All SZGR 2.0 genes in this pathway
PID A6B1 A6B4整合素途径	46	35	All SZGR 2.0 genes in this pathway
PID RAC1 REG PATHWAY	38	25	All SZGR 2.0 genes in this pathway
PID ARF 3PATHWAY	19	13	All SZGR 2.0 genes in this pathway
PID Ephrinb Rev Pathway	30	25	All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY	33	32	All SZGR 2.0 genes in this pathway
PID S1P S1P2途径	24	19	All SZGR 2.0 genes in this pathway
PID EPHA2 FWD PATHWAY	19	16	All SZGR 2.0 genes in this pathway
PID整合素A4B1途径	33	24	All SZGR 2.0 genes in this pathway
PID Rac1途径	54	37	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
Rho GTPases的Reactome信号传导	113	81	All SZGR 2.0 genes in this pathway
NGF的Reactome信号传导	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
Reactome发育生物学	396	292	All SZGR 2.0 genes in this pathway
Reactome细胞通信	120	77	All SZGR 2.0 genes in this pathway
Reactome Nrage通过JNK发出死亡的信号	43	33	All SZGR 2.0 genes in this pathway
Reactome细胞死亡信号通过Nrage NRIF和NADE传导	60	43	All SZGR 2.0 genes in this pathway
Reactome P75 NTR受体介导的信号传导	81	61	All SZGR 2.0 genes in this pathway
GPCR的反应组信号传导	920	449	All SZGR 2.0 genes in this pathway
REACTOME GPVI MEDIATED ACTIVATION CASCADE	31	25	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
Reactome G alpha1213信号传导事件	74	56	All SZGR 2.0 genes in this pathway
Reactome CD28 CO刺激	32	26	All SZGR 2.0 genes in this pathway
Reactome GPCR下游信号传导	805	368	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF RAC	14	11	All SZGR 2.0 genes in this pathway
Reactome sema3a pak依赖性轴突排斥	15	14	All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT VAV1 PATHWAY	11	10	All SZGR 2.0 genes in this pathway
Semaphorin信号中的Reactome SemA4D	32	22	All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS	68	53	All SZGR 2.0 genes in this pathway
Reactome SemA4D诱导细胞迁移和生长锥塌陷	27	21	All SZGR 2.0 genes in this pathway
Reactome Sema3a丛集蛋白排斥信号通过抑制整联蛋白粘附	13	9	All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY	63	48	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ROBO RECEPTOR	30	26	All SZGR 2.0 genes in this pathway
Reactome L1CAM相互作用	86	62	All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING	41	30	All SZGR 2.0 genes in this pathway
L1反应组信号转导	34	25	All SZGR 2.0 genes in this pathway
Reactome DCC介导的有吸引力的信号	13	11	All SZGR 2.0 genes in this pathway
巨核细胞发育和血小板产生涉及的反应组因素	132	101	All SZGR 2.0 genes in this pathway
REACTOME DSCAM INTERACTIONS	11	10	All SZGR 2.0 genes in this pathway
反应组止血	466	331	All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION	207	122	All SZGR 2.0 genes in this pathway
Reactome宿主的艾滋病毒因素的相互作用	132	81	All SZGR 2.0 genes in this pathway
Reactome NEF在HIV1复制和疾病发病机理中的作用	28	19	All SZGR 2.0 genes in this pathway
Reactome免疫系统	933	616	All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统	539	350	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL UP	73	50	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
TIMOFEEVA GROWTH STRESS VIA STAT1 DN	16	12	All SZGR 2.0 genes in this pathway
Borczuk恶性间皮瘤	305	185	All SZGR 2.0 genes in this pathway
Senese HDAC1靶向DN	260	143	All SZGR 2.0 genes in this pathway
EWSR1 FLII融合的Kinsey目标	1278	748	All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞	530	342	All SZGR 2.0 genes in this pathway
王食道癌与正常DN	101	66	All SZGR 2.0 genes in this pathway
LI LUNG CANCER	41	30	All SZGR 2.0 genes in this pathway
Dairkee Tert目标	380	213	All SZGR 2.0 genes in this pathway
CALVET IRINOTECAN SENSITIVE VS REVERTED UP	5	5	All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向DN	1024	594	All SZGR 2.0 genes in this pathway
弗里德曼衰老	77	60	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
牙肺纹状横纹肌肉瘤DN	408	274	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP	69	41	All SZGR 2.0 genes in this pathway
WHITESIDE CISPLATIN RESISTANCE UP	11	7	All SZGR 2.0 genes in this pathway
村上紫外线响应6小时	37	31	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
Maclachlan BRCA1靶向	21	16	All SZGR 2.0 genes in this pathway
Verrecchia延迟对TGFB1的响应	39	26	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN	88	58	All SZGR 2.0 genes in this pathway
Verrecchia对TGFB1 C4的响应	13	10	All SZGR 2.0 genes in this pathway
Yoshimura MAPK8目标DN	366	257	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP	91	63	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP	84	60	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL IL3RA	9	6	All SZGR 2.0 genes in this pathway
Johnstone Parvb目标3 DN	918	550	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family	目标位置			mirna id	miRNA seq
miRNA family	UTR start	UTR end	Match method	mirna id	miRNA seq
miR-101	537	544	1a,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-137	987	993	1a	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
mir-142-3p	747	754	1a,m8	HSA-MIR-142-3P	uguaguuuccuacuuuaugga
mir-144	538	544	1a	hsa-miR-144	uacaguauagauguauguaguag
mir-182	308	315	1a,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
mir-194	127	133	1a	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
MiR-200BC/429	715	721	m8	hsa-miR-200b	uaauacugccugguaaugaugac
				hsa-miR-200c	uaauacugccggguaaugaugg
				HSA-MIR-429	uaauacuguguguguguguaaaaaccgu
miR-361	1018	1025	1a,m8	hsa-miR-361^脑	UUAUCAGAAUCUCCAGGGGUAC
mir-485-3p	1493	1499	m8	hsa-miR-485-3p	gucauacgggcucucucucucucu
mir-485-5p	466	472	m8	hsa - mir - 485 - 5 - p	aggcuggccgugaugauuc
miR-495	125	131	1a	hsa-miR-495^脑	AAACAAACAUGGUGCACUUCUUU
mir-96	309	315	1a	HSA-MIR-96^脑	UUUGGCACUAGCACAUUUUUGC
mir-99/100	777	783	1a	HSA-MIR-99A^脑	AACCCGUAGAUCCGAUCUUGUG
				hsa-miR-100^脑	AACCCGUAGAUCCGAACUUGUG
				HSA-MIR-99B^脑	CACCCGUAGAACCGACCUUGCG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhere查看与SZ相关的miRNA列表。
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.

基因页：Rac1