Gene Page:RAD51B

Summary?
GeneID 5890
Symbol RAD51B
Synonyms R51H2|RAD51L1|REC2
Description RAD51 paralog B
Reference MIM:602948|HGNC:HGNC:9822|Ensembl:ENSG00000182185|HPRD:04255|Vega:OTTHUMG00000157530
Gene type protein-coding
Map location 14q23-q24.2
Pascal p-value 0.182
Sherlock p-value 0.349
Fetal beta 0.348
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Montano_2016 Genome-wide DNA methylation analysis This dataset includes 172 replicated associations between CpGs with schizophrenia. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg10975863 14 68830704 RAD51B 6.9E-7 0.011 0.014 DMG:Montano_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DOPEY1 0.91 0.93
KIAA0528 0.91 0.93
BRWD1 0.90 0.93
BTAF1 0.90 0.92
C12orf30 0.89 0.94
ZFC3H1 0.89 0.90
YTHDC2 0.89 0.93
ZNF655 0.89 0.92
HLTF 0.89 0.93
ZNF248 0.88 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.70 -0.78
MT-CO2 -0.70 -0.78
FXYD1 -0.69 -0.77
HIGD1B -0.69 -0.81
IFI27 -0.67 -0.77
HSD17B14 -0.67 -0.73
CST3 -0.66 -0.77
MT-CYB -0.66 -0.74
METRN -0.66 -0.78
ENHO -0.66 -0.81

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG HOMOLOGOUS RECOMBINATION 28 17 All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132 101 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
考夫曼DNA修复基因 230 137 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA UP 61 40 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP 64 40 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP 56 34 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE UP 60 42 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA UP 60 40 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 UP 62 35 All SZGR 2.0 genes in this pathway
WENG POR TARGETS GLOBAL DN 23 14 All SZGR 2.0 genes in this pathway
WENG POR TARGETS LIVER DN 20 11 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP 180 114 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP 139 95 All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA UP 75 43 All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA DN 80 53 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 0 76 54 All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS UP 44 30 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
YU BAP1 TARGETS 29 21 All SZGR 2.0 genes in this pathway