Gene Page:RALA

Summary?
GeneID 5898
Symbol RALA
Synonyms RAL
Description v-ral simian leukemia viral oncogene homolog A (ras related)
Reference MIM:179550|HGNC:HGNC:9839|Ensembl:ENSG00000006451|HPRD:01549|Vega:OTTHUMG00000128775
Gene type protein-coding
Map location 7p15-p13
Pascal p-value 0.374
Sherlock p-value 0.492
Fetal beta 1.098
DMG 1 (# studies)
Support INTRACELLULAR SIGNAL TRANSDUCTION
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Potential synaptic genes

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0309

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg11610702 7 39773227 RALA 1.33E-11 -0.036 2.84E-7 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KIAA1009 0.93 0.90
KIAA1731 0.93 0.91
C21orf66 0.91 0.90
ZNF841 0.90 0.91
ZFC3H1 0.90 0.92
CSPP1 0.90 0.91
RBM6 0.90 0.88
CEP290 0.90 0.87
CENPJ 0.90 0.89
ZNF471 0.90 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.65 -0.77
IFI27 -0.64 -0.76
ENHO -0.63 -0.80
HIGD1B -0.63 -0.77
MT-CO2 -0.63 -0.75
AF347015.27 -0.61 -0.71
TSC22D4 -0.61 -0.69
FXYD1 -0.61 -0.72
RAMP1 -0.61 -0.70
HLA-F -0.61 -0.65

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005515 protein binding 新闻学会 7673236
GO:0005525 GTP binding TAS 2550440
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007265 Ras protein signal transduction EXP 11520933
GO:0006935 chemotaxis TAS 10848592
GO:0044419 interspecies interaction between organisms IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005886 plasma membrane IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ARF1 - ADP-ribosylation factor 1 Reconstituted Complex BioGRID 9688545
ARF1 - ADP-ribosylation factor 1 - HPRD 12509462
ARF6 DKFZp564M0264 ADP-ribosylation factor 6 Affinity Capture-Western BioGRID 12509462
CNKSR2 CNK2 | KIAA0902 | KSR2 connector enhancer of kinase suppressor of Ras 2 - HPRD,BioGRID 14597674
CSDA CSDA1 | DBPA | ZONAB cold shock domain protein A RalA interacts with ZONAB. This interaction was modeled on a demonstrated interaction between human or canine RalA and canine ZONAB. BIND 15592429
EXOC1 BM-102 | FLJ10893 | SEC3 | SEC3L1 | SEC3P exocyst complex component 1 - HPRD 11406615
EXOC2 FLJ11026 | SEC5 | SEC5L1 | Sec5p exocyst complex component 2 - HPRD,BioGRID 12839989
EXOC2 FLJ11026 | SEC5 | SEC5L1 | Sec5p exocyst complex component 2 - HPRD 11744922|12624092
|14525976
EXOC2 FLJ11026 | SEC5 | SEC5L1 | Sec5p exocyst complex component 2 RalA interacts with Sec5. This interaction was modelled on a demonstrated interaction between human RalA and Sec5 from an unspecified species. BIND 15920473
EXOC4 MGC27170 | REC8 | SEC8 | SEC8L1 | Sec8p exocyst complex component 4 - HPRD 11406615
EXOC7 2-5-3p | DKFZp686J04253 | EX070 | EXO70 | EXOC1 | Exo70p | FLJ40965 | FLJ46415 | YJL085W exocyst complex component 7 - HPRD 11406615
EXOC8 EXO84 | Exo84p | SEC84 exocyst complex component 8 - HPRD,BioGRID 14525976
FLNA ABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2 filamin A, alpha (actin binding protein 280) - HPRD,BioGRID 10051605
HRAS C-BAS / | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX| HAMSV | HRAS1 | K-RAS | N-RAS | RASH1 v-Ha-ras Harvey rat sarcoma viral oncogene homolog Two-hybrid BioGRID 11786539
LRPAP1 A2MRAP | A2RAP | HBP44 | MGC138272 | MRAP | RAP low density lipoprotein receptor-related protein associated protein 1 Reconstituted Complex BioGRID 11167825
PLD1 - phospholipase D1, phosphatidylcholine-specific - HPRD,BioGRID 9207251
RAB8B FLJ38125 RAB8B, member RAS oncogene family - HPRD 10889189
RALBP1 RIP1 | RLIP1 | RLIP76 ralA binding protein 1 - HPRD,BioGRID 7673236
RALBP1 RIP1 | RLIP1 | RLIP76 ralA binding protein 1 RalA interacts with RalBP1. BIND 15592429
RALBP1 RIP1 | RLIP1 | RLIP76 ralA binding protein 1 RalA interacts with RLIP76. BIND 7673236
RALGPS1 KIAA0351 | RALGEF2 | RALGPS1A Ral GEF with PH domain and SH3 binding motif 1 - HPRD,BioGRID 10889189
RAP1A KREV-1 | KREV1 | RAP1 | SMGP21 RAP1A, member of RAS oncogene family Two-hybrid BioGRID 11786539
RAP2A K-REV | KREV | RAP2 | RbBP-30 RAP2A, member of RAS oncogene family Two-hybrid BioGRID 11786539
RAP2B MGC20484 RAP2B, member of RAS oncogene family Two-hybrid BioGRID 11786539
RGL2 HKE1.5 | KE1.5 | RAB2L ral guanine nucleotide dissociation stimulator-like 2 Two-hybrid BioGRID 8939933
RGL4 MGC119678 | MGC119680 | Rgr ral guanine nucleotide dissociation stimulator-like 4 - HPRD,BioGRID 12874025
TSC2 FLJ43106 | LAM | TSC4 tuberous sclerosis 2 Affinity Capture-Western BioGRID 12842888


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 70 56 All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY 23 20 All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY 82 62 All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY 49 34 All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY 31 25 All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 49 43 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS 27 23 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS 36 30 All SZGR 2.0 genes in this pathway
REACTOME P38MAPK EVENTS 13 12 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 UP 38 27 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS RED DN 25 19 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP 137 84 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
CHOI ATL STAGE PREDICTOR 44 24 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC 108 74 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
OXFORD RALA TARGETS DN 10 8 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6 144 98 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
STOSSI RESPONSE TO ESTRADIOL 50 35 All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A DN 76 57 All SZGR 2.0 genes in this pathway
布莱洛克的艾尔ZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 108 71 All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS UP 100 72 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 3HR 74 47 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP 134 84 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245 159 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN 175 103 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221 135 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10 69 38 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS 220 133 All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP 146 75 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 1462 1468 1A hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-124.1 594 601 1A,m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 594 600 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-153 452 458 1A hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-181 238 245 1A,m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-183 772 779 1A,m8 hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-221/222 241 247 m8 hsa-miR-221brain AGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brain AGCUACAUCUGGCUACUGGGUCUC
miR-24 1838 1844 1A hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-27 519 525 1A hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-29 1760 1766 1A hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-30-3p 79 85 m8 hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p CUUUCAGUCGGAUGUUUACAGC
miR-329 638 644 m8 hsa-miR-329brain AACACACCUGGUUAACCUCUUU
miR-34b 389 395 m8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-369-3p 341 347 1A hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 341 348 1A,m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-376 1764 1770 1A hsa-miR-376a AUCAUAGAGGAAAAUCCACGU
hsa-miR-376b AUCAUAGAGGAAAAUCCAUGUU
miR-448 452 458 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU