Gene Page:跑

概括?
GeneID 5901
Symbol 跑
Synonyms ARA24|Gsp1|TC4
Description 跑, member RAS oncogene family
Reference MIM:601179|HGNC:HGNC:9846|Ensembl:ENSG00000132341|HPRD:03109|Vega:OTTHUMG00000134328
Gene type protein-coding
Map location 12q24.3
Pascal p-value 0.424
Sherlock p-value 0.807
Fetal beta 0.208
eGene Myers' cis & trans
Support G2Cdb.humanNRC
G2Cdb.humanPSP

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
Network 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 Contribution to shortest path in PPI network: 0.0519

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7132043 chr12 80968399 跑 5901 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KNTC1 0.95 0.85
PLK4 0.95 0.83
BRCA2 0.95 0.75
HELLS 0.94 0.74
SMC4 0.94 0.87
MCM8 0.94 0.81
C6orf167 0.94 0.85
FANCI 0.94 0.69
CENPI 0.94 0.79
TIMELESS 0.94 0.86
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.52 -0.71
PTH1R -0.52 -0.70
FBXO2 -0.51 -0.64
HLA-F -0.51 -0.68
AF347015.31 -0.50 -0.77
CA4 -0.50 -0.72
IFI27 -0.50 -0.80
TNFSF12 -0.49 -0.65
AF347015.27 -0.49 -0.74
MT-CO2 -0.49 -0.78

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003682 chromatin binding TAS 1961752
GO:0003713 transcription coactivator activity NAS 15572661
GO:0003924 GTPase活性 EXP 7878053
GO:0003924 GTPase活性 TAS 10400640
GO:0005515 protein binding IPI 1961752
GO:0005525 GTP binding IDA 1961752
GO:0050681 androgen receptor binding NAS 15572661
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006405 RNA从核出口 NAS -
GO:0006259 DNA metabolic process TAS 8421051
GO:0007165 signal transduction TAS 7603572
GO:0007067 有丝分裂 TAS 8421051
GO:0007052 mitotic spindle organization TAS 10408446
GO:0007264 small GTPase mediated signal transduction IEA -
GO:0006913 nucleocytoplasmic transport IEA -
GO:0006611 protein export from nucleus NAS -
GO:0006886 intracellular protein transport IEA -
GO:0030521 androgen receptor signaling pathway NAS 15572661
GO:0045893 positive regulation of transcription, DNA-dependent NAS 15572661
GO:0044419 interspecies interaction between organisms IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0000785 chromatin IDA 1961752
GO:0005829 cytosol EXP 7878053
GO:0005634 nucleus IEA -
GO:0005643 nuclear pore NAS 8421051
GO:0005654 nucleoplasm EXP 9405152|9837918
GO:0005737 细胞质 IDA 1961752
GO:0042470 melanosome IEA -

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental 资源 PubMed ID
ABL1 ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl c-abl oncogene 1, receptor tyrosine kinase - HPRD,BioGRID 11420673
AR AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM androgen receptor - HPRD,BioGRID 10400640
ASAP2 Amap2 |Centb3 |ddef2 |FLJ42910 |KIAA0400 |pag3 |PAP |pap-alpha |shag1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 - HPRD 10022920
BMPR1B ALK-6 | ALK6 | CDw293 bone morphogenetic protein receptor, type IB BMPR1B interacts with RAN. This interaction was modeled on a demonstrated interaction between human BMPR1B and mouse RAN. BIND 15761153
CSE1L 中科院| CSE1 | MGC117283 | MGC130036 | MGC130037 | XPO2 CSE1 chromosome segregation 1-like (yeast) - HPRD 9323134
IPO11 RanBP11 importin 11 - HPRD 11809816
IPO5 DKFZp686O1576 | FLJ43041 | IMB3 | KPNB3 | MGC2068 | RANBP5 importin 5 - HPRD,BioGRID 9114010
IPO7 FLJ14581 | Imp7 | MGC138673 | RANBP7 importin 7 - HPRD 9214382
KIAA1377 - KIAA1377 两个杂交 BioGRID 16169070
KPNB1 IMB1 | IPOB | Impnb | MGC2155 | MGC2156 | MGC2157 | NTF97 karyopherin (importin) beta 1 Far Western
Reconstituted Complex		 BioGRID 9102465|9135132
|10779340
KPNB1 IMB1 | IPOB | Impnb | MGC2155 | MGC2156 | MGC2157 | NTF97 karyopherin (importin) beta 1 - HPRD 8576188|9135132
KPNB1 IMB1 | IPOB | Impnb | MGC2155 | MGC2156 | MGC2157 | NTF97 karyopherin (importin) beta 1 Interaction between KPNB1 (PDB ID: 1IBR_B) and RAN (PDB ID: 1IBR_A). BIND 7615630|7627554
|8896452|10367892
NEK9 DKFZp434D0935 | MGC138306 | MGC16714 | NERCC | NERCC1 | Nek8 NIMA (never in mitosis gene a)- related kinase 9 - HPRD,BioGRID 12101123
NR3C1 GCCR | GCR | GR | GRL nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 两个杂交 BioGRID 10508170
NUP153 HNUP153 | N153 nucleoporin 153kDa Reconstituted Complex BioGRID 10202161
NUP50 MGC39961 | NPAP60 | NPAP60L nucleoporin 50kDa - HPRD 12176322
NUTF2 NTF2 | PP15 nuclear transport factor 2 - HPRD 8757804|9368653
|9533885|9822603
|10679025
NUTF2 NTF2 | PP15 nuclear transport factor 2 Co-crystal Structure
Reconstituted Complex		 BioGRID 9533885|15522285
PTMA MGC104802 | TMSA prothymosin, alpha - HPRD 11310559
跑BP1 HTF9A | MGC88701 跑binding protein 1 - HPRD,BioGRID 7891706|10779340
跑BP10 FLJ31165 | KIAA1464 跑binding protein 10 - HPRD,BioGRID 14684163
跑BP2 NUP358 | TRP1 | TRP2 跑binding protein 2 - HPRD,BioGRID 10318915
跑BP3 DKFZp586I1520 跑binding protein 3 - HPRD,BioGRID 9637251
跑BP9 跑BPM 跑binding protein 9 - HPRD,BioGRID 9817760
跑GAP1 Fug1 | KIAA1835 | MGC20266 | SD Ran GTPase activating protein 1 - HPRD,BioGRID 7744835|9219684
|10394366
rangrf DKFZP686F02139 |HSPC165 |HSPC236 |MGC110973 |Mog1 |rangnrf 跑guanine nucleotide release factor - HPRD,BioGRID 11290418
RCC1 CHC1 | RCC1-I regulator of chromosome condensation 1 Co-crystal Structure
Reconstituted Complex
两个杂交		 BioGRID 7891706|10369786
|10811801|11336674
RCC1 CHC1 | RCC1-I regulator of chromosome condensation 1 - HPRD 10369786|12194828
RGPD5 BS-63 | DKFZp686I1842 | RANBP2L1 | RGP5 跑BP2-like and GRIP domain containing 5 - HPRD 11774384
SMAD1 BSP1 | JV4-1 | JV41 | MADH1 | MADR1 SMAD family member 1 SMAD1 interacts with RAN. This interaction was modeled on a demonstrated interaction between human SMAD1 and mouse RAN. BIND 15761153
SMARCB1 BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFS SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Reconstituted Complex BioGRID 11782423
TGFBR1 AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1 transforming growth factor, beta receptor 1 TGF-beta-RI interacts with RAN. This interaction was modeled on a demonstrated interaction between human TGF-beta-RI and mouse RAN. BIND 15761153
TNPO1 IPO2 | KPNB2 | MIP | MIP1 | TRN transportin 1 - HPRD,BioGRID 10353245
XPO1 CRM1 | DKFZp686B1823 exportin 1 (CRM1 homolog, yeast) - HPRD,BioGRID 9323133
XPO5 FLJ14239 | FLJ32057 | FLJ45606 | KIAA1291 exportin 5 - HPRD,BioGRID 11777942
XPO6 EXP6 | FLJ22519 | KIAA0370 | RANBP20 exportin 6 亲和力捕获ms BioGRID 14592989
XPOT XPO3 exportin, tRNA (nuclear export receptor for tRNAs) - HPRD,BioGRID 9660920|12138183


V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA RANMS PATHWAY 10 7 该途径中的所有SZGR 2.0基因
PID HDAC CLASSII PATHWAY 34 27 该途径中的所有SZGR 2.0基因
PID NFKAPPAB规范途径 23 20 该途径中的所有SZGR 2.0基因
PID HDAC CLASSI PATHWAY 66 50 该途径中的所有SZGR 2.0基因
PID NFAT 3 Pathway 54 47 该途径中的所有SZGR 2.0基因
PID FOXO PATHWAY 49 43 该途径中的所有SZGR 2.0基因
PID RANBP2途径 11 11 该途径中的所有SZGR 2.0基因
pid aurora a通道 31 20 该途径中的所有SZGR 2.0基因
REACTOME MICRORNA MIRNA BIOGENESIS 23 9 该途径中的所有SZGR 2.0基因
REACTOME REGULATORY RNA PATHWAYS 26 12 该途径中的所有SZGR 2.0基因
REACTOME INFLUENZA LIFE CYCLE 203 72 该途径中的所有SZGR 2.0基因
REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY 27 19 该途径中的所有SZGR 2.0基因
REACTOME HIV INFECTION 207 122 该途径中的所有SZGR 2.0基因
Reactome HIV生命周期 125 69 该途径中的所有SZGR 2.0基因
REACTOME HOST INTERACTIONS OF HIV FACTORS 132 81 该途径中的所有SZGR 2.0基因
REACTOME LATE PHASE OF HIV LIFE CYCLE 104 61 该途径中的所有SZGR 2.0基因
WINTER HYPOXIA UP 92 57 该途径中的所有SZGR 2.0基因
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294 178 该途径中的所有SZGR 2.0基因
GARY CD5 TARGETS DN 431 263 该途径中的所有SZGR 2.0基因
Borczuk恶性间皮瘤 305 185 该途径中的所有SZGR 2.0基因
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 该途径中的所有SZGR 2.0基因
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 该途径中的所有SZGR 2.0基因
LUI THYROID CANCER PAX8 PPARG DN 45 29 该途径中的所有SZGR 2.0基因
Hwang前列腺癌标记 28 19 该途径中的所有SZGR 2.0基因
LI AMPLIFIED IN LUNG CANCER 178 108 该途径中的所有SZGR 2.0基因
MATTIOLI MGUS VS PCL 116 62 该途径中的所有SZGR 2.0基因
GRASEMANN RETINOBLASTOMA WITH 6P AMPLIFICATION 14 14 该途径中的所有SZGR 2.0基因
LUI TARGETS OF PAX8 PPARG FUSION 34 23 该途径中的所有SZGR 2.0基因
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 159 93 该途径中的所有SZGR 2.0基因
SCHLOSSER MYC TARGETS AND SERUM RESPONSE DN 47 34 该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK 1652 1023 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
PUJANA CHEK2 PCC NETWORK 779 480 该途径中的所有SZGR 2.0基因
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP 167 92 该途径中的所有SZGR 2.0基因
LOPEZ MBD TARGETS 957 597 该途径中的所有SZGR 2.0基因
SCIAN CELL CYCLE TARGETS OF TP53 AND TP73 DN 22 14 该途径中的所有SZGR 2.0基因
BENPORATH CYCLING GENES 648 385 该途径中的所有SZGR 2.0基因
Sakai肿瘤浸润单核细胞DN 81 51 该途径中的所有SZGR 2.0基因
MORI PRE BI LYMPHOCYTE UP 80 54 该途径中的所有SZGR 2.0基因
MORI LARGE PRE BII LYMPHOCYTE UP 86 49 该途径中的所有SZGR 2.0基因
MORI IMMATURE B LYMPHOCYTE DN 90 55 该途径中的所有SZGR 2.0基因
SANA RESPONSE TO IFNG DN 85 56 该途径中的所有SZGR 2.0基因
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 该途径中的所有SZGR 2.0基因
PEART HDAC PROLIFERATION CLUSTER DN 76 57 该途径中的所有SZGR 2.0基因
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 该途径中的所有SZGR 2.0基因
MOREAUX B LYMPHOCYTE MATURATION BY TACI DN 73 45 该途径中的所有SZGR 2.0基因
MA MYELOID DIFFERENTIATION UP 39 29 该途径中的所有SZGR 2.0基因
MOREAUX MULTIPLE MYELOMA BY TACI DN 172 107 该途径中的所有SZGR 2.0基因
MUNSHI MULTIPLE MYELOMA UP 81 52 该途径中的所有SZGR 2.0基因
KAAB FAILED HEART ATRIUM DN 141 99 该途径中的所有SZGR 2.0基因
ZAMORA NOS2 TARGETS UP 69 41 该途径中的所有SZGR 2.0基因
LU AGING BRAIN DN 153 120 该途径中的所有SZGR 2.0基因
Yamazaki TCEB3靶向DN 215 132 该途径中的所有SZGR 2.0基因
DAZARD RESPONSE TO UV SCC UP 123 75 该途径中的所有SZGR 2.0基因
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE 77 50 该途径中的所有SZGR 2.0基因
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM 66 47 该途径中的所有SZGR 2.0基因
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 132 93 该途径中的所有SZGR 2.0基因
HELLER HDAC TARGETS DN 292 189 该途径中的所有SZGR 2.0基因
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 该途径中的所有SZGR 2.0基因
GRADE COLON AND RECTAL CANCER UP 285 167 该途径中的所有SZGR 2.0基因
ALONSO METASTASIS EMT UP 36 24 该途径中的所有SZGR 2.0基因
ALONSO METASTASIS UP 198 128 该途径中的所有SZGR 2.0基因
Lee Liver Cancer生存DN 175 103 该途径中的所有SZGR 2.0基因
MOOTHA MITOCHONDRIA 447 277 该途径中的所有SZGR 2.0基因
GOLDRATH ANTIGEN RESPONSE 346 192 该途径中的所有SZGR 2.0基因
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163 102 该途径中的所有SZGR 2.0基因
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 该途径中的所有SZGR 2.0基因
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193 112 该途径中的所有SZGR 2.0基因
开罗肝母细胞瘤上课 605 377 该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 143 86 该途径中的所有SZGR 2.0基因
WHITFIELD CELL CYCLE M G1 148 95 该途径中的所有SZGR 2.0基因
MARTENS TRETINOIN RESPONSE DN 841 431 该途径中的所有SZGR 2.0基因
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 该途径中的所有SZGR 2.0基因
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 该途径中的所有SZGR 2.0基因
KIM ALL DISORDERS CALB1 CORR UP 548 370 该途径中的所有SZGR 2.0基因
PILON KLF1 TARGETS DN 1972 1213 该途径中的所有SZGR 2.0基因
LEE BMP2 TARGETS DN 882 538 该途径中的所有SZGR 2.0基因
RAO BOUND BY SALL4 ISOFORM A 182 108 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
mir-151 27 33 m8 hsa-miR-151brain ACUAGACUGAAGCUCCUUGAGG
miR-181 156 162 m8 hsa-miR-181abrain aacauucaacgcugucggugagu
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-324-5p 124 130 m8 HSA-MIR-324-5p CGCAUCCCCUAGGGCAUUGGUGU