Gene Page:RAP2A

Summary?
GeneID 5911
Symbol RAP2A
Synonyms K-REV|KREV|RAP2|RbBP-30
Description RAP2A, member of RAS oncogene family
Reference MIM:179540|HGNC:HGNC:9861|HPRD:01547|
Gene type protein-coding
Map location 13q34
帕斯卡pvalue 0.04
Sherlock p-value 0.5
Fetal beta 0.081
DMG 1 (# studies)
Support INTRACELLULAR SIGNAL TRANSDUCTION
G2Cdb.humanNRC
G2Cdb.humanPSP
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
简历:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0384

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25329939 13 98085947 RAP2A 6.57E-9 -0.013 3.39E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003924 GTPase activity TAS 1900290
GO:0005525 三磷酸鸟苷结合 IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007165 signal transduction TAS 3045729
GO:0007264 small GTPase mediated signal transduction IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005886 plasma membrane IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ARHGAP29 PARG1 | RP11-255E17.1 Rho GTPase activating protein 29 PARG1 interacts with Rap2. BIND 15752761
GABARAPL2 ATG8 | GATE-16 | GATE16 | GEF-2 | GEF2 GABA(A) receptor-associated protein-like 2 Biochemical Activity BioGRID 12581858
GRIN1 NMDA1 | NMDAR1 | NR1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 - HPRD 10862698
MLLT4 AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 - HPRD 10224125
RAF1 CRAF | NS5 | Raf-1 | c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 Raf-1 interacts with Rap2. This interaction was modeled on a demonstrated interaction between Raf-1 from unspecified species and human Rap2. BIND 15752761
RALA MGC48949 | RAL v-ral simian leukemia viral oncogene homolog A (ras related) Two-hybrid BioGRID 11786539
RALGDS FLJ20922 | RGF | RalGEF ral guanine nucleotide dissociation stimulator - HPRD,BioGRID 10085114
RAPGEF3 CAMP-GEFI | EPAC | EPAC1 | HSU79275 | MGC21410 | bcm910 Rap guanine nucleotide exchange factor (GEF) 3 Biochemical Activity BioGRID 10777494
RAPGEF4 CAMP-GEFII | CGEF2 | EPAC2 | Nbla00496 Rap guanine nucleotide exchange factor (GEF) 4 Biochemical Activity BioGRID 10777494
RAPGEF5 GFR | KIAA0277 | MR-GEF | REPAC Rap guanine nucleotide exchange factor (GEF) 5 Biochemical Activity BioGRID 10777494
RAPGEF6 DKFZp667N084 | DKFZp686I15116 | KIA001LB | PDZ-GEF2 | PDZGEF2 | RA-GEF-2 Rap guanine nucleotide exchange factor (GEF) 6 - HPRD,BioGRID 11524421|12581858
RASIP1 FLJ20401 | RAIN Ras interacting protein 1 - HPRD 15031288
RASSF5 MGC10823 | MGC17344 | Maxp1 | NORE1 | NORE1A | NORE1B | RAPL | RASSF3 Ras association (RalGDS/AF-6) domain family member 5 - HPRD,BioGRID 11857081
RGS14 - regulator of G-protein signaling 14 - HPRD,BioGRID 10926822
RUNDC3A RAP2IP | RPIP8 RUN domain containing 3A - HPRD,BioGRID 9523700
TNIK - TRAF2 and NCK interacting kinase - HPRD 15342639


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408 247 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS DN 123 78 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205 127 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276 165 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP 194 112 All SZGR 2.0 genes in this pathway
由阿霉素GRAESSMANN细胞凋亡UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227 137 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN DN 13 8 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246 180 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225 139 All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153 120 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 105 73 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202 132 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249 165 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317 177 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 3 33 12 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G12 UP 39 17 All SZGR 2.0 genes in this pathway
SYED ESTRADIOL RESPONSE 19 15 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207 143 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN 103 67 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-10 251 257 m8 hsa-miR-10a UACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10b UACCCUGUAGAACCGAAUUUGU
miR-124.1 2638 2645 1A,m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 2638 2644 1A hsa - mir - 506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-135 885 891 m8 hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-186 2678 2684 1A hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-203.1 3450 3457 1A,m8 hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-223 3388 3394 m8 hsa-miR-223 UGUCAGUUUGUCAAAUACCCC
miR-320 1056 1062 1A hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-326 3347 3354 1A,m8 hsa-miR-326 CCUCUGGGCCCUUCCUCCAG
miR-33 3485 3492 1A,m8 hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-330 2892 2899 1A,m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-9 2663 2669 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA