Gene Page:RARA

概括?
GeneID 5914
Symbol RARA
Synonyms NR1B1|RAR
描述 retinoic acid receptor alpha
参考 MIM：180240|HGNC:HGNC:9864|Ensembl:ENSG00000131759|HPRD:06769|Vega：Otthumg00000133328
Gene type protein-coding
Map location 17q21
Pascal p-value 0.168
Sherlock P值 0.21
Fetal beta -0.445
DMG 1（＃研究）

数据源中的基因
Gene set name Method of gene set 描述 Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur 高通量文献搜索 Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 高通量文献搜索 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) beta（dis） FDR (dis) Study
CG08580254 17 38478807 RARA 1.544e-4 0.271 0.032 DMG:Wockner_2014
cg19314352 17 38501397 RARA 2.395E-4 0.537 0.037 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
去：0003700 转录因子活性 IEA -
去：0003707 steroid hormone receptor activity IEA -
去：0003708 retinoic acid receptor activity IEA -
去：0003713 transcription coactivator activity IDA 2825025
GO:0001972 retinoic acid binding IDA 2825025
GO:0005515 protein binding 新闻学会 10866662|16432238|17560333
GO:0008270 zinc ion binding IEA -
GO:0046872 金属离子结合 IEA -
GO:0043565 序列特异性DNA结合 IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0030520 雌激素受体信号通路 IDA 15831516
GO:0006350 transcription IEA -
GO:0007165 signal transduction IDA 2825025
GO:0048384 retinoic acid receptor signaling pathway 小鬼 17538076
GO:0032689 negative regulation of interferon-gamma production IDA 18416830
GO:0032526 response to retinoic acid 小鬼 17538076
GO:0032754 白介素5产生的正调节 IDA 18416830
GO:0032753 positive regulation of interleukin-4 production IDA 18416830
GO:0032720 negative regulation of tumor necrosis factor production IDA 18416830
GO:0032736 positive regulation of interleukin-13 production IDA 18416830
GO:0032355 对雌二醇刺激的反应 IDA 15831516
GO:0045630 positive regulation of T-helper 2 cell differentiation IDA 18416830
细胞分量 GO term Evidence Neuro keywords PubMed ID
GO:0005634 核 IEA -
GO:0009986 cell surface IC 2825025

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental 资源 PubMed ID
ANP32A C15orf1 | I1PP2A | LANP | MAPM | MGC119787 | MGC150373 | PHAP1 | PHAPI | PP32 酸性（富含亮氨酸）核磷蛋白32家族，成员A RAR-alpha interacts with pp32. BIND 15308690
ARNTL BMAL1 | BMAL1c | JAP3 | MGC47515 | MOP3 | PASD3 | TIC | bHLHe5 aryl hydrocarbon receptor nuclear translocator-like Reconstituted Complex BioGRID 11439184
BAG1 RAP46 BCL2-associated athanogene - HPRD,BioGRID 9642262
BTG1 - B细胞易位基因1，抗增殖 BTG1 interacts with RARA (RAR-alpha). BIND 15674337
CCND3 - cyclin D3 in vitro
in vivo
两个杂交		 BioGRID 12482873
CDK7 CAK1 | CDKN7 | MO15 | STK1 | p39MO15 cyclin-dependent kinase 7 RAR-Alpha与HMO15相互作用。 BIND 15249124
CLOCK KAT13D | KIAA0334 | bHLHe8 clock homolog (mouse) Reconstituted Complex
两个杂交		 BioGRID 11439184
GADD45A DDIT1 | GADD45 growth arrest and DNA-damage-inducible, alpha Affinity Capture-Western BioGRID 10872826
GADD45G CR6 | DDIT2 | GADD45gamma | GRP17 growth arrest and DNA-damage-inducible, gamma Reconstituted Complex BioGRID 10872826
GATA2 MGC2306 | NFE1B GATA binding protein 2 - HPRD 10938104
HDAC3 HD3 | RPD3 | RPD3-2 histone deacetylase 3 Reconstituted Complex BioGRID 12943985
HDAC4 HA6116 | HD4 | HDAC-A | HDACA | KIAA0288 histone deacetylase 4 Reconstituted Complex BioGRID 12943985
IRX4 IRXA3 | MGC131996 iroquois homeobox 4 - HPRD,BioGRID 11382777
JARID1A KDM5A | RBBP2 | RBP2 jumonji, AT rich interactive domain 1A Reconstituted Complex BioGRID 11358960
JARID1A KDM5A | RBBP2 | RBP2 jumonji, AT rich interactive domain 1A Rbp2 interacts with RAR. BIND 11358960
KAT2B CAF | P | P/CAF | PCAF K(lysine) acetyltransferase 2B Affinity Capture-Western BioGRID 14581481
KLF5 BTEB2 | CKLF | IKLF Kruppel-like factor 5 (intestinal) in vitro
in vivo		 BioGRID 12101409
MECR CGI-63 | FASN2B | NRBF1 mitochondrial trans-2-enoyl-CoA reductase - HPRD,BioGRID 9795230
MED6 NY-REN-28 mediator complex subunit 6 Med6 interacts with RAR-alpha. BIND 15808511
NCOA1 F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42 nuclear receptor coactivator 1 RAR-alpha interacts with SRC-1. BIND 15249124
NCOA1 F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42 nuclear receptor coactivator 1 - HPRD 12138096
NCOA2 GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2 nuclear receptor coactivator 2 GRIP1与RAR相互作用。这种相互作用是在小鼠grip1和人RAR之间证明的相互作用上建模的。 BIND 9920895
NCOA3 ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIP nuclear receptor coactivator 3 RAC3 interacts with RAR-alpha. BIND 9238002
NCOA6 AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBP nuclear receptor coactivator 6 - HPRD,BioGRID 10567404
NCOR1 KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoR nuclear receptor co-repressor 1 NCOR1（N-COR）与P-RAR-ALPHA2（RAR-ALPHA2启动子）相互作用。 BIND 15729358
NCOR1 KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoR nuclear receptor co-repressor 1 Reconstituted Complex
两个杂交		 BioGRID 9531570|10336495
NCOR2 CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1 nuclear receptor co-repressor 2 Affinity Capture-Western
Reconstituted Complex		 BioGRID 9256429|11929748
NCOR2 CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1 nuclear receptor co-repressor 2 NCOR2 (SMRT) interacts with p-RAR-alpha2 (RAR-alpha2 promoter). BIND 15729358
NKX2-1 BCH | BHC | NK-2 | NKX2.1 | NKX2A | TEBP | TITF1 | TTF-1 | TTF1 NK2 HONEOBOX 1 - HPRD,BioGRID 10617585
NPAS2 FLJ23138 | MGC71151 | MOP4 | PASD4 | bHLHe9 neuronal PAS domain protein 2 Reconstituted Complex
两个杂交		 BioGRID 11439184
NR0B2 FLJ17090 | SHP | SHP1 nuclear receptor subfamily 0, group B, member 2 - HPRD,BioGRID 9773978
NR1H3 lxr-a |LXRA |RLD-1 nuclear receptor subfamily 1, group H, member 3 - HPRD 10022764
NR2E3 ESCS | MGC49976 | PNR | RNR | RP37 | rd7 nuclear receptor subfamily 2, group E, member 3 - HPRD,BioGRID 10611353
NR4A2 HZF-3 |不|nurr1 |RNR1 |Tinur nuclear receptor subfamily 4, group A, member 2 Reconstituted Complex
两个杂交		 BioGRID 7705655
NRBF2 copr1 |copr2 |DKFZP564C1664 |FLJ30395 |NRBF-2 核受体结合因子2 - HPRD,BioGRID 10786636
NRIP1 FLJ77253 |RIP140 nuclear receptor interacting protein 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 8887632|12549917
|14581481
NRIP1 FLJ77253 |RIP140 nuclear receptor interacting protein 1 - HPRD 12403842|12549917
NRIP2 DKFZP761G1913 nuclear receptor interacting protein 2 - HPRD 10860982
NSD1 ARA267 |DKFZP666C163 |FLJ10684 |FLJ22263 |FLJ44628 |KMT3B |sotos |斯托 nuclear receptor binding SET domain protein 1 - HPRD 9628876
PARP1 ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1 poly (ADP-ribose) polymerase 1 PARP-1 interacts with RAR-alpha. BIND 15808511
PML MYL | PP8675 | RNF71 | TRIM19 promyelocytic leukemia - HPRD 12935927
PML MYL | PP8675 | RNF71 | TRIM19 promyelocytic leukemia Reconstituted Complex BioGRID 10610177
PNRC2 FLJ20312 | MGC99541 proline-rich nuclear receptor coactivator 2 - HPRD 11574675
POU2F1 OCT1 | OTF1 POU 2级同型1 Reconstituted Complex BioGRID 10480874
PRMT2 HRMT1L1 | MGC111373 protein arginine methyltransferase 2 PRMT2与RAR相互作用。 BIND 12039952
RARA NR1B1 | RAR retinoic acid receptor, alpha Reconstituted Complex BioGRID 14521715
RBP2 Crabp-ii |CRBP2 |crbpii |RBPC2 retinol binding protein 2, cellular - HPRD 11358960
RXRA FLJ00280 |FLJ00318 |FLJ16020 |FLJ16733 |MGC102720 |NR2B1 retinoid X receptor, alpha Co-purification
Reconstituted Complex		 BioGRID 1314167|12052862
RXRB DAUDI6 | H-2RIIBP | MGC1831 | NR2B2 | RCoR-1 retinoid X receptor, beta 两个杂交 BioGRID 16189514
RXRG NR2B3 | RXRC retinoid X receptor, gamma 两个杂交 BioGRID 16189514
SP1 - Sp1 transcription factor Reconstituted Complex BioGRID 10361124
spen KIAA0929 | MINT | RP1-134O19.1 | SHARP spen homolog, transcriptional regulator (Drosophila) - HPRD 11331609
SRC ASV |src1 |C-SRC |P60-SRC v - src肉瘤(Schmidt-Ruppin A-2) viral oncogene homolog (avian) Reconstituted Complex BioGRID 10454579
TADA3L ADA3 |FLJ20221 |FLJ21329 |hada3 转录适配器3（NGG1同源性，酵母）类似 - HPRD,BioGRID 12235159
TDG - thymine-DNA glycosylase Reconstituted Complex BioGRID 12874288
TNFRSF10B CD262 | DR5 | KILLER | KILLER/DR5 | TRAIL-R2 | TRAILR2 | TRICK2 | TRICK2A | TRICK2B | TRICKB | ZTNFR9 肿瘤坏死因子受体超家族，成员10b RARA (RAR-alpha) interacts with TNFRSF10B (DR5) RARE. BIND 12805378
TRIM24 PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1 tripartite motif-containing 24 Reconstituted Complex BioGRID 9115274
TRIP4 HST17391 thyroid hormone receptor interactor 4 - HPRD,BioGRID 10454579
ZBTB16 PLZF | ZNF145 锌指和包含16的BTB结构域 - HPRD,BioGRID 14521715


V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG PATHWAYS IN CANCER 328 259 该途径中的所有SZGR 2.0基因
KEGG ACUTE MYELOID LEUKEMIA 60 47 该途径中的所有SZGR 2.0基因
BIOCARTA EGFR SMRTE PATHWAY 11 11 该途径中的所有SZGR 2.0基因
BIOCARTA RARRXR PATHWAY 15 9 该途径中的所有SZGR 2.0基因
BIOCARTA NUCLEARRS PATHWAY 15 12 该途径中的所有SZGR 2.0基因
BIOCARTA PML PATHWAY 17 12 该途径中的所有SZGR 2.0基因
BIOCARTA CARM1 PATHWAY 13 11 该途径中的所有SZGR 2.0基因
PID RXR VDR途径 26 24 该途径中的所有SZGR 2.0基因
pid视黄酸途径 30 23 该途径中的所有SZGR 2.0基因
REACTOME GENERIC TRANSCRIPTION PATHWAY 352 181 该途径中的所有SZGR 2.0基因
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 49 36 该途径中的所有SZGR 2.0基因
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 该途径中的所有SZGR 2.0基因
THUM SYSTOLIC HEART FAILURE UP 423 283 该途径中的所有SZGR 2.0基因
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158 103 该途径中的所有SZGR 2.0基因
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR DN 41 29 该途径中的所有SZGR 2.0基因
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 126 86 该途径中的所有SZGR 2.0基因
MULLIGHAN NPM1 MUTATED SIGNATURE 2 DN 77 46 该途径中的所有SZGR 2.0基因
MULLIGHAN NPM1 SIGNATURE 3 DN 162 116 该途径中的所有SZGR 2.0基因
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187 115 该途径中的所有SZGR 2.0基因
UDAYAKUMAR MED1 TARGETS DN 240 171 该途径中的所有SZGR 2.0基因
TIEN INTESTINE PROBIOTICS 24HR DN 214 133 该途径中的所有SZGR 2.0基因
NAGASHIMA NRG1 SIGNALING UP 176 123 该途径中的所有SZGR 2.0基因
KIM WT1 TARGETS UP 214 155 该途径中的所有SZGR 2.0基因
GOZGIT ESR1 TARGETS DN 781 465 该途径中的所有SZGR 2.0基因
Lindgren膀胱癌群集1 121 71 该途径中的所有SZGR 2.0基因
BERENJENO TRANSFORMED BY RHOA DN 394 258 该途径中的所有SZGR 2.0基因
LINDGREN BLADDER CANCER WITH LOH IN CHR9Q 116 71 该途径中的所有SZGR 2.0基因
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 该途径中的所有SZGR 2.0基因
ETS1和SP100 UP的Yordy倒数调节 25 11 该途径中的所有SZGR 2.0基因
SCHLESINGER METHYLATED DE NOVO IN CANCER 88 64 该途径中的所有SZGR 2.0基因
LOPEZ MBD TARGETS 957 597 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON 133 78 该途径中的所有SZGR 2.0基因
BYSTROEM CORRELATED WITH IL5 DN 64 47 该途径中的所有SZGR 2.0基因
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN 66 47 该途径中的所有SZGR 2.0基因
FERNANDEZ BOUND BY MYC 182 116 该途径中的所有SZGR 2.0基因
霍夫曼细胞淋巴瘤DN 39 29 该途径中的所有SZGR 2.0基因
ABRAHAM ALPC VS MULTIPLE MYELOMA UP 26 22 该途径中的所有SZGR 2.0基因
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 该途径中的所有SZGR 2.0基因
EHRLICH ICF SYNDROM UP 13 8 该途径中的所有SZGR 2.0基因
MOREIRA RESPONSE TO TSA UP 28 23 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 该途径中的所有SZGR 2.0基因
Krige对Tosedostat的反应24小时 783 442 该途径中的所有SZGR 2.0基因
ACEVEDO LIVER CANCER WITH H3K9ME3 UP 141 75 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER BASAL DN 701 446 该途径中的所有SZGR 2.0基因
BERNARD PPAPDC1B TARGETS DN 58 39 该途径中的所有SZGR 2.0基因
MATZUK SPERMATOCYTE 72 55 该途径中的所有SZGR 2.0基因
WEST ADRENOCORTICAL TUMOR DN 546 362 该途径中的所有SZGR 2.0基因
GRESHOCK CANCER COPY NUMBER UP 323 240 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
Vantveer乳腺癌ESR1 UP 167 99 该途径中的所有SZGR 2.0基因
TAVAZOIE METASTASIS 108 68 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 该途径中的所有SZGR 2.0基因
DANG REGULATED BY MYC DN 253 192 该途径中的所有SZGR 2.0基因
DANG MYC TARGETS DN 31 25 该途径中的所有SZGR 2.0基因
DANG BOUND BY MYC 1103 714 该途径中的所有SZGR 2.0基因
MARTENS BOUND BY PML RARA FUSION 456 287 该途径中的所有SZGR 2.0基因
GREGORY SYNTHETIC LETHAL WITH IMATINIB 145 83 该途径中的所有SZGR 2.0基因
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229 149 该途径中的所有SZGR 2.0基因
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 该途径中的所有SZGR 2.0基因
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 该途径中的所有SZGR 2.0基因
KASLER HDAC7 TARGETS 1 UP 194 133 该途径中的所有SZGR 2.0基因
Duan PRDM5目标 79 52 该途径中的所有SZGR 2.0基因
PURBEY TARGETS OF CTBP1 AND SATB1 UP 87 52 该途径中的所有SZGR 2.0基因
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 该途径中的所有SZGR 2.0基因
VANOEVELEN MYOGENESIS SIN3A TARGETS 220 133 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR start UTR end Match method
mir-128 739 745 1A HSA-MIR-128A UCACAGUGAACCGGUCUCUUUU
HSA-MIR-128B UCACAGUGAACCGGUCUCUUUC
mir-135 374 380 m8 hsa-miR-135a Uauggcuuuuuuuuccuauga
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
mir-138 329 336 1A,m8 hsa-miR-138脑 AGCUGGUGUUGUGAAUC
hsa-miR-138脑 AGCUGGUGUUGUGAAUC
miR-205 578 584 1A HSA-MIR-205 uccuucauucccggagucug
miR-218 564 570 m8 HSA-MIR-218脑 uugugcuugaucuaaccaugu
miR-27 739 746 1A,m8 hsa-miR-27a脑 UUCACAGUGGCUAAGUUCCGC
hsa-miR-27b脑 UUCACAGUGGCUAAGUUCUGC