Gene Page:RASA1
Summary?
GeneID | 5921 |
Symbol | RASA1 |
Synonyms | cm-avm | cmavm | gap | pkws | rasa | rasgap | p120 | p120gap | p120rasgap |
Description | RAS p21 protein activator 1 |
Reference | MIM:139150|HGNC:HGNC:9871|ENSEMBL:ENSG00000145715|HPRD:00745|Vega:OTTHUMG00000162605 |
基因类型 | 蛋白质编码 |
Map location | 5q13.3 |
Pascal p-value | 0.64 |
Sherlock p-value | 0.678 |
胎儿β | 0.423 |
DMG | 1(# studies) |
Gene in Data Sources
基因集名称 | Method of gene set | Description | 信息 |
---|---|---|---|
简历:PGCnp | Genome-wide Association Study | GWAS | |
DMG:JAFFE_2016 | 全基因组DNA甲基化分析 | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
GO_Annotation | 将与神经相关的关键字映射到基因本体论注释 | Hits with neuro-related keywords: 2 | |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | PPI网络中最短路径的贡献:0.2213 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | 染色体 | 位置 | Nearest gene | p(dis) | Beta (dis) | fdr(dis) | 学习 |
---|---|---|---|---|---|---|---|
cg09490071 | 5 | 86564760 | RASA1 | 2.7E-9 | -0.022 | 1.95E-6 | DMG:JAFFE_2016 |
第二节。转录组注释
一般基因表达(GTEX)
![Not available](http://www.tjghsg.com/bioinfo/SZGR/GeneImg/RASA1_DE_GTEx.png)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达(brainspan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25%和上层25%。
No co-expressed genes in brain regions
第三节。基因本体论注释
Molecular function | 去学期 | 证据 | 神经关键字 | PubMed ID |
---|---|---|---|---|
去:0005102 | receptor binding | IPI | 神经递质(GO期限:4) | 2157284|2176151 |
GO:0005099 | Ras GTPase activator activity | TAS | 2188736 | |
GO:0019870 | potassium channel inhibitor activity | nas | 1553544 | |
去:0051020 | GTPase binding | IPI | 2122974 | |
Biological process | 去学期 | 证据 | 神经关键字 | PubMed ID |
GO:0043524 | negative regulation of neuron apoptosis | ISS | 神经元(GO期限:9) | - |
GO:0001570 | vasculogenesis | ISS | - | |
GO:0000910 | 细胞因子 | ISS | - | |
GO:0001953 | negative regulation of cell-matrix adhesion | IDA | 8344248 | |
GO:0007242 | 细胞内信号传导级联 | nas | 1581965 | |
GO:0008360 | regulation of cell shape | nas | 9113414 | |
GO:0009790 | embryonic development | ISS | - | |
GO:0051056 | regulation of small GTPase mediated signal transduction | IEA | - | |
GO:0051252 | regulation of RNA metabolic process | nas | 9113414 | |
GO:0030833 | regulation of actin filament polymerization | IDA | 8344248 | |
GO:0045768 | positive regulation of anti-apoptosis | IDA | 15542850 | |
Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
GO:0001726 | ruffle | IEA | - | |
去:0005622 | 细胞内 | IEA | - | |
去:0005737 | cytoplasm | nas | 2821624 | |
去:0005886 | plasma membrane | IEA | - |
Section IV. Protein-protein interaction annotation
Interactors | 别名b | 官方全名b | 实验 | Source | PubMed ID |
---|---|---|---|---|---|
ABL1 | ABL |JTK7 |BCR/ABL |c-abl |P150 |V-ABL | C-ABL癌基因1,受体酪氨酸激酶 | c-Abl interacts with GAP. | 绑定 | 1383690 |
ALK | CD246 | Ki-1 | TFG/ALK | 肿瘤淋巴瘤受体酪氨酸激酶 | - | HPRD | 9174053 |
anxa6 | ANX6 | CBP68 | annexin A6 | - | HPRD,BioGRID | 8798684|10571081 |
anxa6 | ANX6 | CBP68 | annexin A6 | Annexin VI interacts with GAP. | 绑定 | 10571081 |
arhgap1 | CDC42GAP | RHOGAP | RHOGAP1 | p50rhoGAP | Rho GTPase激活蛋白1 | - | HPRD | 9034330 |
arhgap5 | GFI2 | RhoGAP5 | p190-B | Rho GTPase激活蛋白5 | GAP interacts with p190. This interaction was modeled on a demonstrated interaction between human GAP and rat p190. | 绑定 | 1689011|8344248 |10769036 |
arhgap5 | GFI2 | RhoGAP5 | p190-B | Rho GTPase激活蛋白5 | - | HPRD | 8537347 |
AURKA | aik |ark1 |光环|Aurora2 |btak |MGC34538 |STK15 |stk6 |STK7 | aurora kinase A | RasGAP interacts with HsAIRK-1. | 绑定 | 11976319 |
AURKB | AIK2 | AIM-1 | AIM1 | ARK2 | AurB | IPL1 | STK12 | STK5 | aurora kinase B | - | HPRD | 11976319 |
AURKB | AIK2 | AIM-1 | AIM1 | ARK2 | AurB | IPL1 | STK12 | STK5 | aurora kinase B | RasGAP interacts with HsAIRK-2 in the RasGAP/HsAIRK-2/survivin complex. | 绑定 | 11976319 |
BCR | 全部|BCR-ABL1 |BCR1 |CML |D22S11 |D22S662 |FLJ16453 |phl | breakpoint cluster region | BCRinteracts with GAP. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human GAP. | 绑定 | 1383690 |
BIRC5 | API4 | EPR-1 | baculoviral IAP repeat-containing 5 | - | HPRD | 11976319 |
CAV2 | CAV | MGC12294 | caveolin 2 | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 12091389 |
CD5 | LEU1 | T1 | CD5 molecule | - | HPRD,BioGRID | 9603468 |
CSF1R | C-FMS | CD115 | CSFR | FIM2 | FMS | colony stimulating factor 1 receptor | - | HPRD,BioGRID | 2172781 |
CSK | MGC117393 | c-src tyrosine kinase | - | HPRD,BioGRID | 7544435 |
DNAJA3 | FLJ45758 | TID1 | hTid-1 | DnaJ (Hsp40) homolog, subfamily A, member 3 | - | HPRD,BioGRID | 11116152 |
DOK1 | MGC117395 | MGC138860 | P62DOK | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | - | HPRD,BioGRID | 9008161 |
DOK1 | MGC117395 | MGC138860 | P62DOK | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | DOK1 interacts with RASGAP | 绑定 | 10822173 |
DOK2 | p56dok |p56dok-2 | docking protein 2, 56kDa | 亲和力捕获 - 韦斯特恩 | Biogrid | 10822173 |
DOK2 | p56dok |p56dok-2 | docking protein 2, 56kDa | Dok2与RASGAP | 绑定 | 10822173 |
DOK2 | p56dok |p56dok-2 | docking protein 2, 56kDa | - | HPRD | 10508618|10799545 |
DOK4 | FLJ10488 | docking protein 4 | - | HPRD | 12730241 |
DOK4 | FLJ10488 | docking protein 4 | IRS5/DOK4 interacts with RasGAP. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster RasGAP. | 绑定 | 12730241 |
egfr | ERBB |ERBB1 |her1 |PIG61 |梅纳 | 表皮生长因子受体(红细胞性白血病病毒(V-ERB-B)癌基因同源物,鸟类) | 重构的复合物 | Biogrid | 8647858 |
egfr | ERBB |ERBB1 |her1 |PIG61 |梅纳 | 表皮生长因子受体(红细胞性白血病病毒(V-ERB-B)癌基因同源物,鸟类) | GAP interacts with EGFR. | 绑定 | 1385407|1850098 |2176151 |
egfr | ERBB |ERBB1 |her1 |PIG61 |梅纳 | 表皮生长因子受体(红细胞性白血病病毒(V-ERB-B)癌基因同源物,鸟类) | - | HPRD | 1633149 |
EPHB2 | CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5 | EPH receptor B2 | - | HPRD,BioGRID | 9233798|10644995 |
EPHB3 | ETK2 |hek2 |Tyro6 | EPH receptor B3 | - | HPRD,BioGRID | 9674711 |
FES | FPS | feline sarcoma oncogene | - | HPRD,BioGRID | 7691175 |
G3BP1 | G3BP | HDH-VIII | MGC111040 | GTPase activating protein (SH3 domain) binding protein 1 | - | HPRD,BioGRID | 9632780 |
GNB2L1 | Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1 | 鸟嘌呤核苷酸结合蛋白(G蛋白),β多肽2类样1 | RACK1 interacts with p120GAP.This interaction was modeled on a demonstrated interaction between RACK1 from mouse and rat, and human p120GAP. | 绑定 | 11350068 |
GNB2L1 | Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1 | 鸟嘌呤核苷酸结合蛋白(G蛋白),β多肽2类样1 | - | HPRD,BioGRID | 11350068 |
GRB2 | 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 | growth factor receptor-bound protein 2 | - | HPRD,BioGRID | 12441060 |
grlf1 | grf-1 |KIAA1722 |MGC10745 |P190-A |P190A |P190RHOGAP | 糖皮质激素受体DNA结合因子1 | 重构的复合物 | Biogrid | 9034330 |
HCK | JTK9 | 血压细胞激酶 | - | HPRD,BioGRID | 7782336 |
HRAS | C-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | - | HPRD,BioGRID | 7628625|9219684 |
HRAS | C-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | - | HPRD | 2833817|7628625 |8663024|9219684 |
HSPD1 | CPN60 | GROEL | HSP60 | HSP65 | HuCHA60 | SPG13 | 热休克60KDA蛋白1(伴侣蛋白) | - | HPRD | 1347942 |
htt | 高清|IT15 | huntingtin | HDP interacts with RasGAP. | 绑定 | 9079622 |
htt | 高清|IT15 | huntingtin | - | HPRD,BioGRID | 9079622 |
IGF1R | CD221 |igfir |JTK13 |MGC142170 |MGC142172 |MGC18216 | insulin-like growth factor 1 receptor | - | HPRD,BioGRID | 7642582 |
INSR | CD220 | HHF5 | 胰岛素受体 | - | HPRD,BioGRID | 1331107 |
KDR | CD309 | FLK1 | VEGFR | VEGFR2 | kinase insert domain receptor (a type III receptor tyrosine kinase) | 亲和力捕获 - 韦斯特恩 | Biogrid | 10319320 |
KHDRBS1 | FLJ34027 | Sam68 | p62 | KH结构域含有RNA结合,信号转导相关1 | - | HPRD,BioGRID | 11604231 |
KHDRBS1 | FLJ34027 | Sam68 | p62 | KH结构域含有RNA结合,信号转导相关1 | Sam68 interacts with the SH2 domains of p120GAP, preferentially with the C-terminal SH2 domain. This interaction was modelled based on a demonstrated interaction between rat proteins. | 绑定 | 11604231 |
magi1 | AIP3 | BAIAP1 | BAP1 | MAGI-1 | TNRC19 | WWP3 | 膜相关的鸟苷酸激酶,WW和PDZ结构域,含有1个 | - | HPRD | 9169421 |
MAP4K4 | FLH21957 |FLJ10410 |FLJ20373 |FLJ90111 |HGK |KIAA0687 |尼克 | 有丝分裂原激活的蛋白激酶激酶激酶激酶4 | - | HPRD,BioGRID | 10669731 |
NCK1 | MGC12668 |NCK |nckalpha | NCK adaptor protein 1 | - | HPRD | 10508618 |
NCK1 | MGC12668 |NCK |nckalpha | NCK adaptor protein 1 | 亲和力捕获 - 韦斯特恩 | Biogrid | 9233798 |
PAG1 | CBP |FLJ37858 |MGC138364 |PAG | 与糖磷脂微域1相关的磷蛋白1 | - | HPRD | 10790433 |
PDE6D | PDED | phosphodiesterase 6D, cGMP-specific, rod, delta | - | HPRD | 11786539 |
PDGFRB | CD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1 | platelet-derived growth factor receptor, beta polypeptide | Activated PDGFR interacts with GAP. This interaction was modeled on a demonstrated interaction between human PDGFR and canine GAP. | 绑定 | 2157284 |
PDGFRB | CD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1 | platelet-derived growth factor receptor, beta polypeptide | GAP的N末端SH2结构域与PDGFR相互作用。这种相互作用是建立在未指定物种的人类和PDGFR之间的间隙之间的相互作用上建模的。 | 绑定 | 1385407|2173144 |7689724|8344248 |
PDGFRB | CD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1 | platelet-derived growth factor receptor, beta polypeptide | - | HPRD,BioGRID | 10697503|11896619 |
PDGFRB | CD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1 | platelet-derived growth factor receptor, beta polypeptide | Autophosphorylated PDGFR interacts with GAP. This interaction was modelled on a demonstrated interaction between human PDGFR and GAP from an unspecified species. | 绑定 | 8890167 |
PIK3R1 | GRB1 | p85 | p85-ALPHA | 磷酸肌醇3-激酶,调节亚基1(alpha) | - | HPRD | 1336372 |
PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | 亲和力捕获 - 韦斯特恩 | Biogrid | 9743338 |
PTK2B | Cadtk |cakb |fadk2 |fak2 |frnk |PKB |PTK |pyk2 |筏 | PTK2B protein tyrosine kinase 2 beta | - | HPRD,BioGRID | 8798684|10708762 |10713673 |
ptprc | B220 | CD45 | CD45R | GP180 | LCA | LY5 | T200一样 | 蛋白酪氨酸磷酸酶,受体类型,C | - | HPRD | 8570203 |
PXN | FLJ16691 | paxillin | - | HPRD,BioGRID | 10092539 |
RAB5A | RAB5 | RAB5A, member RAS oncogene family | - | HPRD | 11536198 |
Rap1a | KREV-1 | KREV1 | RAP1 | SMGP21 | Rap1a, member of RAS oncogene family | in vivo | Biogrid | 2164710 |
SLC9A2 | NHE2 | solute carrier family 9 (sodium/hydrogen exchanger), member 2 | - | HPRD,BioGRID | 10187839 |
SOCS3 | ATOD4 | CIS3 | Cish3 | MGC71791 | SOCS-3 | SSI-3 | SSI3 | 抑制细胞因子信号传导3 | - | HPRD,BioGRID | 11331873 |
SRC | ASV | SRC1 | c-SRC | p60-Src | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | - | HPRD,BioGRID | 1717825 |
SYN1 | Syn1a |SYN1B |Syni | 突触i | - | HPRD,BioGRID | 10899172 |
WWP1 | AIP5 |DKFZP434D2111 |tiul1 |HSDRP1 | 含有E3泛素蛋白连接酶1的WW结构域1 | - | HPRD | 9169421 |
WWP2 | AIP2 |像WWP2一样 | 含有E3泛素蛋白连接酶2的WW结构域2 | - | HPRD | 9169421 |
YES1 | HST441 |p61-yes |是|c-yes | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | - | HPRD,BioGRID | 1544885 |
ZAP70 | FLJ17670 |FLJ17679 |SRK |std |tzk |ZAP-70 | Zeta链(TCR)相关蛋白激酶70KDA | - | HPRD,BioGRID | 7760813 |
Section V. Pathway annotation
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | mirna seq | ||
---|---|---|---|---|---|
UTR开始 | UTR结束 | 匹配方法 | |||
mir-1/206 | 105 | 112 | 1A,M8 | hsa-miR-1 | UGGAAUGUAAAGAAGUAUGUA |
hsa-miR-206SZ | UGGAAUGUAAGGAAGUGUGUGG | ||||
hsa-miR-613 | AGGAAUGUUCCUUCUUUGCC | ||||
mir-132/212 | 473 | 479 | M8 | hsa-miR-212SZ | UAACAGUCUCCAGUCACGGCC |
HSA-MIR-132brain | UAACAGUCUACAGCCAUGGUCG | ||||
miR-145 | 415 | 421 | M8 | HSA-MIR-145 | GUCCAGUUUUCCCAGGAAUCCCUU |
miR-153 | 125 | 132 | 1A,M8 | HSA-MIR-153 | UUGCAUAGUCACAAAAGUGA |
miR-182 | 334 | 341 | 1A,M8 | HSA-MIR-182 | UUUGGCAAUGGUAGAACUCACA |
HSA-MIR-182 | UUUGGCAAUGGUAGAACUCACA | ||||
miR-21 | 179 | 185 | 1A | hsa-miR-21brain | UAGCUUAUCAGACUGAUGUUGA |
hsa-miR-590 | GAGCUUAUUCAUAAAAGUGCAG | ||||
mir-223 | 377 | 384 | 1A,M8 | hsa-miR-223 | ugucuuugucaauacccc |
miR-24 | 238 | 244 | M8 | hsa-miR-24SZ | uggcucucagagcaggaagag |
mir-30-5p | 700 | 707 | 1A,M8 | hsa-miR-30a-5p | UGUAAACAUCCUCGACUGGAAG |
hsa-miR-30cbrain | UGUAAACAUCCUACACUCUCAGC | ||||
hsa-miR-30dSZ | UGUAAACAUCCCCGACUGGAAG | ||||
hsa-miR-30bSZ | uguaaacauccuaccucucagcu | ||||
hsa-miR-30e-5p | UGUAAACAUCCUUGACUGGA | ||||
miR-31 | 78 | 85 | 1A,M8 | hsa-miR-31 | Aggcaagaugcuggcauagcug |
mir-320 | 620 | 627 | 1A,M8 | hsa-miR-320 | aaaagcugggugagaggggcgaa |
mir-335 | 76 | 82 | M8 | hsa-miR-335brain | UCAAGAGCAAUAACGAAAAAUGU |
mir-342 | 118 | 124 | M8 | hsa-miR-342brain | ucucacacagaaaucgcacccccguc |
miR-374 | 517 | 523 | 1A | HSA-MIR-374 | uuauaauacaAccugauaagug |
miR-376 | 367 | 373 | 1A | hsa-miR-376a | aucauagaaaaauccacgu |
hsa-miR-376b | AUCAUAGAGGAAAAUCCAUGUU | ||||
miR-377 | 117 | 123 | M8 | HSA-MIR-377 | AUCACACAAAGGCAACUUUUGU |
mir-448 | 126 | 132 | 1A | hsa-miR-448 | UUGCAUAUGUAGGAUGUCCCAU |
mir-505 | 583 | 589 | 1A | hsa-miR-505 | gucaacuugcugguuccuc |
miR-96 | 335 | 341 | 1A | hsa-miR-96brain | uuuggcacuagcacauuuuugc |
hsa-miR-96brain | uuuggcacuagcacauuuuugc |