Gene Page:RBL1

Summary?
GeneID 5933
Symbol RBL1
Synonyms CP107|PRB1|p107
Description retinoblastoma-like 1
Reference MIM:116957|HGNC:HGNC:9893|Ensembl:ENSG00000080839|HPRD:00312|Vega:OTTHUMG00000032406
Gene type protein-coding
Map location 20q11.2
Pascal p-value 0.222
Fetal beta 1.471
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg21570468 20 35724588 RBL1 5.41E-8 -0.005 1.4E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KIAA1429 0.93 0.93
CEBPZ 0.93 0.93
PRPF40A 0.92 0.93
XPO1 0.92 0.93
RMI1 0.92 0.91
N4BP2L2 0.92 0.92
DHX15 0.92 0.92
NUP54 0.92 0.92
CRNKL1 0.92 0.91
USP1 0.91 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.69 -0.83
AF347015.31 -0.69 -0.83
AF347015.33 -0.67 -0.80
AF347015.27 -0.67 -0.80
MT-CYB -0.67 -0.81
AF347015.8 -0.67 -0.82
AF347015.15 -0.66 -0.82
PTH1R -0.66 -0.76
HLA-F -0.65 -0.74
IFI27 -0.65 -0.82

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AATF CHE-1 | CHE1 | DED apoptosis antagonizing transcription factor Affinity Capture-Western BioGRID 12450794
ARID4A RBBP1 | RBP-1 | RBP1 AT rich interactive domain 4A (RBP1-like) Affinity Capture-Western BioGRID 10490602
BEGAIN KIAA1446 brain-enriched guanylate kinase-associated homolog (rat) Affinity Capture-Western
Two-hybrid		 BioGRID 16189514
BRCA1 BRCAI | BRCC1 | IRIS | PSCP | RNF53 早发性乳腺癌 Co-localization
Reconstituted Complex		 BioGRID 11521194
BRF1 BRF | FLJ42674 | FLJ43034 | GTF3B | MGC105048 | TAF3B2 | TAF3C | TAFIII90 | TF3B90 | TFIIIB90 | hBRF BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) - HPRD,BioGRID 10330166
CCNA1 - cyclin A1 Reconstituted Complex BioGRID 10022926
CCNA2 CCN1 | CCNA cyclin A2 - HPRD,BioGRID 1532458|8230483
|12439743
CCND1 BCL1 | D11S287E | PRAD1 | U21B31 cyclin D1 - HPRD,BioGRID 8643455
CCNE1 CCNE cyclin E1 - HPRD 8230483
CCNE1 CCNE cyclin E1 Affinity Capture-Western BioGRID 9891079
CDK2 p33(CDK2) cyclin-dependent kinase 2 Biochemical Activity
in vitro
in vivo		 BioGRID 9891079|11884610
CDK2 p33(CDK2) cyclin-dependent kinase 2 - HPRD 8230483|11884610
CDKN1C BWCR | BWS | KIP2 | WBS | p57 cyclin-dependent kinase inhibitor 1C (p57, Kip2) Affinity Capture-Western BioGRID 12947099
CREG1 CREG cellular repressor of E1A-stimulated genes 1 - HPRD,BioGRID 9710587
E2F1 E2F-1 | RBAP1 | RBBP3 | RBP3 E2F transcription factor 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 8230483
E2F1 E2F-1 | RBAP1 | RBBP3 | RBP3 E2F transcription factor 1 E2F1 interacts with the p107 promoter region. BIND 10766737
E2F2 E2F-2 E2F transcription factor 2 E2F2 interacts with the p107 promoter region. BIND 10766737
E2F4 E2F-4 E2F transcription factor 4, p107/p130-binding E2F4 interacts with the p107 promoter region. BIND 10766737
E2F4 E2F-4 E2F transcription factor 4, p107/p130-binding p107 interacts with E2F4. BIND 8816797
E2F4 E2F-4 E2F transcription factor 4, p107/p130-binding - HPRD,BioGRID 8643455|11573202
|12150994
E2F5 E2F-5 p130-binding E2F转录因子5日 Two-hybrid BioGRID 7760804
HDAC1 DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 histone deacetylase 1 - HPRD,BioGRID 9724731
HDAC2 RPD3 | YAF1 histone deacetylase 2 Affinity Capture-Western BioGRID 10490602
HDAC3 HD3 | RPD3 | RPD3-2 histone deacetylase 3 Affinity Capture-Western BioGRID 10490602
JARID1A KDM5A | RBBP2 | RBP2 jumonji, AT rich interactive domain 1A - HPRD,BioGRID 7935440
LIN9 BARA | BARPsv | Lin-9 | TGS | TGS1 lin-9 homolog (C. elegans) hMip130/TWIT interacts with p107. BIND 15479636
MCM7 CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146 minichromosome maintenance complex component 7 - HPRD,BioGRID 9566894
MCM7 CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146 minichromosome maintenance complex component 7 MCM7 interacts with p107. BIND 9566894
MT1G MGC12386 | MT1 | MT1K metallothionein 1G RBL1 (P107) interacts with the MT1G promoter. BIND 15735762
MYBL2 B-MYB | BMYB | MGC15600 v-myb myeloblastosis viral oncogene homolog (avian)-like 2 - HPRD,BioGRID 12439743|12947099
MYC bHLHe39 | c-Myc v-myc myelocytomatosis viral oncogene homolog (avian) - HPRD,BioGRID 8076603
PHB PHB1 prohibitin in vitro
in vivo		 BioGRID 10376528
PPP2R3A PPP2R3 | PR130 | PR72 protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha Affinity Capture-Western BioGRID 9927208
RB1 OSRC | RB | p105-Rb | pRb | pp110 retinoblastoma 1 Rb interacts with the p107 promoter. BIND 15716956
RB1 OSRC | RB | p105-Rb | pRb | pp110 retinoblastoma 1 Affinity Capture-Western BioGRID 10490602
RBBP8 CTIP | RIM retinoblastoma binding protein 8 - HPRD,BioGRID 9721205
RBBP9 BOG | MGC9236 | RBBP10 retinoblastoma binding protein 9 - HPRD,BioGRID 9697699
RBL2 FLJ26459 | P130 | Rb2 retinoblastoma-like 2 (p130) p130 interacts with the p107 promoter region. BIND 10766737
SMAD2 JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2 SMAD family member 2 - HPRD 12150994
SMAD3 DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396 SMAD family member 3 - HPRD,BioGRID 12150994
SMAD4 DPC4 | JIP | MADH4 SMAD family member 4 - HPRD,BioGRID 12150994
SNW1 Bx42 | MGC119379 | NCOA-62 | PRPF45 | Prp45 | SKIIP | SKIP SNW domain containing 1 - HPRD,BioGRID 12466551
SUV39H1 KMT1A | MG44 | SUV39H suppressor of variegation 3-9 homolog 1 (Drosophila) Affinity Capture-Western BioGRID 12588981
TAF1 BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa - HPRD,BioGRID 9242374
TFDP1 DP1 | DRTF1 | Dp-1 转录前沿空中管制官tor Dp-1 Affinity Capture-Western BioGRID 7739537
TFDP2 DP2 | Dp-2 转录前沿空中管制官tor Dp-2 (E2F dimerization partner 2) Affinity Capture-Western BioGRID 7739537
USP4 MGC149848 | MGC149849 | UNP | Unph ubiquitin specific peptidase 4 (proto-oncogene) in vitro
in vivo		 BioGRID 11571651
UXT ART-27 ubiquitously-expressed transcript p107 interacts with the UXT chromatin. BIND 11799066


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CELL CYCLE 128 84 All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY 86 64 All SZGR 2.0 genes in this pathway
BIOCARTA CELLCYCLE PATHWAY 23 15 All SZGR 2.0 genes in this pathway
BIOCARTA ETS PATHWAY 18 12 All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 82 63 All SZGR 2.0 genes in this pathway
PID E2F PATHWAY 74 48 All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 63 52 All SZGR 2.0 genes in this pathway
REACTOME G0 AND EARLY G1 25 13 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 27 17 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 38 26 All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352 181 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE 38 23 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 137 79 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 63 42 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP 126 72 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP 115 78 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
STREICHER LSM1 TARGETS UP 44 34 All SZGR 2.0 genes in this pathway
STREICHER LSM1 TARGETS DN 19 13 All SZGR 2.0 genes in this pathway
KONG E2F3 TARGETS 97 58 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 77 51 All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 1 DN 38 23 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164 111 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP 69 55 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED 100 68 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN 103 64 All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN 76 52 All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP 108 75 All SZGR 2.0 genes in this pathway
REN BOUND BY E2F 61 40 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP 89 51 All SZGR 2.0 genes in this pathway
KAMMINGA EZH2 TARGETS 41 26 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP 203 135 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
CHEN ETV5 TARGETS TESTIS 23 14 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373 196 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 88 65 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP 180 114 All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN 92 64 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425 253 All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250 168 All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163 102 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185 116 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277 166 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS DN 89 50 All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS DN 41 25 All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS DN 42 23 All SZGR 2.0 genes in this pathway
PYEON CANCER HEAD AND NECK VS CERVICAL UP 193 95 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229 149 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
YU BAP1 TARGETS 29 21 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182 108 All SZGR 2.0 genes in this pathway