SZGR2 - Beplay体育中心

Summary?

GeneID	595
Symbol	CCND1
Synonyms	BCL1\|D11S287E\|PRAD1\|U21B31
Description	cyclin D1
Reference	MIM:168461\|HGNC:HGNC:1582\|Ensembl:ENSG00000110092\|HPRD:01346\|Vega:OTTHUMG00000167877
Gene type	protein-coding
Map location	11q13
Pascal p-value	0.591
Sherlock p-value	0.045
Fetal beta	-0.397
DMG	1 (# studies)
eGene	Myers' cis & trans Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
PMID:cooccur	High-throughput literature-search	系统search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.015

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg05200606	11	69457819	CCND1	1.42E-8	-0.017	5.5E-6	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs11708509	chr3	98075542	CCND1	595		0.18		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

十大积极co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ARFGAP2	0.89	0.87
VPS26B	0.89	0.89
VPS4A	0.88	0.85
RNF187	0.88	0.84
GDI1	0.88	0.83
L3MBTL2	0.86	0.83
PPP2R2D	0.85	0.82
TBC1D10B	0.85	0.83
CSRP2BP	0.85	0.80
METTL13	0.85	0.83

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.76	-0.74
AF347015.31	-0.75	-0.74
AF347015.8	-0.72	-0.73
AF347015.21	-0.72	-0.70
AF347015.33	-0.72	-0.69
AF347015.2	-0.71	-0.69
HIGD1B	-0.71	-0.73
MT-CYB	-0.71	-0.70
FXYD1	-0.71	-0.73
AF347015.26	-0.70	-0.68

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	新闻学会		15232106\|17254966\|17274640 \|17334399
GO:0004672	protein kinase activity	IEA		-
GO:0016538	cyclin-dependent protein kinase regulator activity	IEA		-
GO:0019901	protein kinase binding	新闻学会		8114739
Biological process	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0000082	G1/S transition of mitotic cell cycle	NAS		-
GO:0000320	re-entry into mitotic cell cycle	IEA		-
GO:0001934	positive regulation of protein amino acid phosphorylation	IDA		8114739
GO:0030968	endoplasmic reticulum unfolded protein response	IEA		-
GO:0051301	cell division	IEA		-
GO:0045737	positive regulation of cyclin-dependent protein kinase activity	IDA		8114739
GO:0045444	fat cell differentiation	IEA		-
GO:0051726	regulation of cell cycle	IEA		-
Cellular component	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IEA		-
GO:0005829	cytosol	EXP		9106657
GO:0005829	cytosol	IEA		-
GO:0005575	cellular_component	ND		-
GO:0005622	intracellular	IDA		11256614
GO:0005634	nucleus	IEA		-
GO:0005654	nucleoplasm	EXP		9190208\|16782892

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	资源	PubMed ID
AKAP8	AKAP95 \| DKFZp586B1222	A kinase (PRKA) anchor protein 8	-	HPRD,BioGRID	14641107
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	10344732
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	-	HPRD,BioGRID	9244350
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	BRCA1 associates with Cyclin D1	BIND	9244350
CALM1	CALML2 \| CAMI \| DD132 \| PHKD	calmodulin 1 (phosphorylase kinase, delta)	-	HPRD	9837900
CCNDBP1	DIP1 \| GCIP	cyclin D-type binding-protein 1	-	HPRD,BioGRID	10801854
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	-	HPRD	9150368\|9837900
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	CDK4 interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between human CDK4 and Cyclin D1 from an unspecified species.	BIND	9228064
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	CCND1 (cyclin D1) interacts with CDK4.	BIND	8662825
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	Affinity Capture-Western Reconstituted Complex	BioGRID	8259215\|9837900 \|10580009\|11360184
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	Affinity Capture-Western Reconstituted Complex	BioGRID	10580009\|11360184
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	-	HPRD	11739795
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	CCND1 (cyclin D1) interacts with CDK6.	BIND	12867429
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	-	HPRD,BioGRID	7478582\|8657154
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	p21 interacts with cyclin D.	BIND	9632134
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	Cyclin D1与P21相互作用。	BIND	8999999
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	CDKN1A (p21) interacts with CCND1 (cyclin D1).	BIND	8662825
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	in vitro Reconstituted Complex	BioGRID	10908655\|11360184
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	p27 interacts with cyclin D.	BIND	9632134
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	-	HPRD	7478582\|10908655
CDKN1C	BWCR \| BWS \| KIP2 \| WBS \| p57	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	Reconstituted Complex	BioGRID	10764802
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	Reconstituted Complex	BioGRID	10580009
CDKN2D	INK4D \| p19 \| p19-INK4D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	-	HPRD	7739547
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	IKK-alpha interacts with cyclin D1 promoter.	BIND	15808510
CREB1	CREB \| MGC9284	cAMP responsive element binding protein 1	CREB interacts with CRE.	BIND	15897899
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	CBP interacts with cyclin D1 promoter.	BIND	15808510
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	CTNNB1 (beta-catenin) interacts with the CCND1 promoter.	BIND	15592430
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	-	HPRD	11836555
CUL3	-	卡林3	-	HPRD	10500095
DMTF1	DMP1 \| DMTF \| FLJ41265 \| hDMP1	cyclin D binding myb-like transcription factor 1	-	HPRD	8887674
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	An unspecified isoform of EGFR binds to Cyclin D1 promoter.	BIND	15950906
EP300	KAT3B \| p300	E1A binding protein p300	-	HPRD,BioGRID	11788592
ERCC3	BTF2 \| GTF2H \| RAD25 \| TFIIH \| XPB	切除repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)	TFIIH interacts with Cyclin D1 promoter.	BIND	15893730
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	雌激素受体1	-	HPRD,BioGRID	9039267
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	雌激素受体1	ER-alpha interacts with cyclin D1 promoter.	BIND	15808510
FOXO4	AFX \| AFX1 \| MGC120490 \| MLLT7	forkhead box O4	MLLT7 (FOXO4) interacts with the CCND1 (Cyclin D1) promoter. This interaction was modelled on a demonstrated interaction between MLLT7 and CCND1 both from unspecified species.	BIND	15688030
HDAC3	HD3 \| RPD3 \| RPD3-2	histone deacetylase 3	Affinity Capture-Western	BioGRID	12048199\|15558026
HERC5	CEB1 \| CEBP1	hect domain and RLD 5	-	HPRD,BioGRID	10581175
IFI27	FAM14D \| ISG12 \| ISG12A \| P27	interferon, alpha-inducible protein 27	-	HPRD	9837900
KAT2B	CAF \| P \| P/CAF \| PCAF	K(lysine) acetyltransferase 2B	-	HPRD,BioGRID	10318892
KLF6	BCD1 \| COPEB \| CPBP \| DKFZp686N0199 \| GBF \| PAC1 \| ST12 \| ZF9	Kruppel-like factor 6	KLF6 interacts with Cyclin D1.	BIND	15172998
MCM10	CNA43 \| DNA43 \| MGC126776 \| PRO2249	minichromosome maintenance complex component 10	-	HPRD	15232106
MYBL2	B-MYB \| BMYB \| MGC15600	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	-	HPRD	10645009
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD,BioGRID	9832502
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	-	HPRD,BioGRID	9832502
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	AIB1 interacts with cyclin D1 promoter.	BIND	15808510
NEUROD1	BETA2 \| BHF-1 \| NEUROD \| bHLHa3	neurogenic differentiation 1	Affinity Capture-Western Phenotypic Suppression	BioGRID	11788592
NPDC1	CAB \| CAB- \| CAB-1 \| CAB1 \| DKFZp586J0523	neural proliferation, differentiation and control, 1	-	HPRD,BioGRID	11042687
PCNA	MGC8367	proliferating cell nuclear antigen	Reconstituted Complex	BioGRID	7908906
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	PIN1 interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between human PIN1 and Cyclin D1 from an unspecified species.	BIND	11805292
POLR2A	MGC75453 \| POLR2 \| POLRA \| RPB1 \| RPBh1 \| RPO2 \| RPOL2 \| RpIILS \| hRPB220 \| hsRPB1	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	Pol II interacts with cyclin D1 promoter.	BIND	15808510
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Rb interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between Cyclin D1 from mouse and Rb from human.	BIND	11126356
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	-	HPRD,BioGRID	8490963
RBL1	CP107 \| MGC40006 \| PRB1 \| p107	retinoblastoma-like 1 (p107)	-	HPRD,BioGRID	8643455
RBX1	BA554C12.1 \| MGC13357 \| MGC1481 \| RNF75 \| ROC1	ring-box 1	-	HPRD,BioGRID	11311237
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	RELA (NF-kappaB p65 subunit) interacts with the CCND1 (Cyclin D1) promoter.	BIND	15652748
RFC1	A1 \| MGC51786 \| MHCBFB \| PO-GA \| RECC1 \| RFC \| RFC140	replication factor C (activator 1) 1, 145kDa	-	HPRD,BioGRID	10353443
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	STAT3的未指定同工型与细胞周期蛋白D1启动子结合。	BIND	15950906
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	-	HPRD,BioGRID	11279133
TAF1	BA2R \| CCG1 \| CCGS \| DYT3 \| KAT4 \| N-TAF1 \| NSCL2 \| OF \| P250 \| TAF2A \| TAFII250	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TAFII250 interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between TAFII250 from human and Cyclin D1 from mouse.	BIND	11126356
TAF1	BA2R \| CCG1 \| CCGS \| DYT3 \| KAT4 \| N-TAF1 \| NSCL2 \| OF \| P250 \| TAF2A \| TAFII250	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	-	HPRD,BioGRID	9926939\|11126356
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	-	HPRD,BioGRID	12048199
THRB	Erba-Beta \|erba2 \|Grth \|MGC126109 \|MGC126110 \|NR1A2 \|prth \|thr1 \|thrb1 \|thrb2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	Affinity Capture-Western Reconstituted Complex	BioGRID	12048199
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	Affinity Capture-Western	BioGRID	16357142
XPO1	CRM1 \| DKFZp686B1823	exportin 1 (CRM1 homolog, yeast)	Reconstituted Complex	BioGRID	12529437

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG P53 SIGNALING PATHWAY	69	45	All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY	151	112	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY	155	105	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER	62	47	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER	52	45	All SZGR 2.0 genes in this pathway
KEGG GLIOMA	65	56	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG THYROID CANCER	29	26	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER	42	33	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA	60	47	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER	54	47	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
BIOCARTA CARM ER PATHWAY	35	27	All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY	28	21	All SZGR 2.0 genes in this pathway
BIOCARTA CELLCYCLE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY	27	26	All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA P53 PATHWAY	16	13	All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY	26	24	All SZGR 2.0 genes in this pathway
WNT SIGNALING	89	71	All SZGR 2.0 genes in this pathway
SA G1 AND S PHASES	15	10	All SZGR 2.0 genes in this pathway
SA REG CASCADE OF CYCLIN EXPR	13	7	All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY	59	49	All SZGR 2.0 genes in this pathway
PID AR PATHWAY	61	46	All SZGR 2.0 genes in this pathway
PID FRA PATHWAY	37	28	All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY	46	39	All SZGR 2.0 genes in this pathway
PID ILK PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY	68	48	All SZGR 2.0 genes in this pathway
PID ECADHERIN新生的AJ通路	39	33	All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY	59	43	All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY	70	60	All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY	40	30	All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY	62	48	All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY	84	61	All SZGR 2.0 genes in this pathway
PID ERA GENOMIC PATHWAY	65	37	All SZGR 2.0 genes in this pathway
PID P38 GAMMA DELTA PATHWAY	11	9	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY	36	31	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	29	17	All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH EXPRESSION AND PROCESSING	44	24	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE	38	23	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH	103	64	All SZGR 2.0 genes in this pathway
REACTOME S PHASE	109	66	All SZGR 2.0 genes in this pathway
PYEON HPV阳性肿瘤DN	10	5	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 6HR DN	18	13	All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN	182	111	All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE DN	66	44	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP	380	215	All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP	133	78	All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS DN	25	18	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN	275	168	All SZGR 2.0 genes in this pathway
BOGNI TREATMENT RELATED MYELOID LEUKEMIA DN	33	19	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN	187	115	All SZGR 2.0 genes in this pathway
LOPEZ MESOTHELIOMA SURVIVAL WORST VS BEST UP	14	10	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN	209	122	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP	265	158	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN	136	94	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 UP	58	39	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP	126	72	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN	229	142	All SZGR 2.0 genes in this pathway
CHIN BREAST CANCER COPY NUMBER UP	27	18	All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID UP	45	26	All SZGR 2.0 genes in this pathway
CAIRO PML TARGETS BOUND BY MYC DN	14	12	All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP	150	93	All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER DN	59	45	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP	58	44	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG UP	44	29	All SZGR 2.0 genes in this pathway
HUMMERICH MALIGNANT SKIN TUMOR UP	16	8	All SZGR 2.0 genes in this pathway
BUSA SAM68 TARGETS UP	7	6	All SZGR 2.0 genes in this pathway
MARKS HDAC TARGETS DN	15	11	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 TTD DN	84	63	All SZGR 2.0 genes in this pathway
BAKER HEMATOPOIESIS STAT3 TARGETS	16	12	All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT5 TARGETS	7	7	All SZGR 2.0 genes in this pathway
SANCHEZ MDM2 TARGETS	15	10	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK TARGETS	18	15	All SZGR 2.0 genes in this pathway
SUZUKI AMPLIFIED IN ORAL CANCER	16	12	All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 23	24	13	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 1	51	33	All SZGR 2.0 genes in this pathway
14问易位MATTIOLI多发性骨髓瘤S	36	25	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
HONRADO BREAST CANCER BRCA1 VS BRCA2	18	12	All SZGR 2.0 genes in this pathway
SNIJDERS AMPLIFIED IN HEAD AND NECK TUMORS	37	27	All SZGR 2.0 genes in this pathway
SCHRAMM INHBA TARGETS UP	7	7	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP	176	111	All SZGR 2.0 genes in this pathway
BORLAK LIVER CANCER EGF UP	57	41	All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS UP	48	23	All SZGR 2.0 genes in this pathway
MAINA VHL TARGETS DN	18	14	All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE IMMORTALIZED DN	31	26	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2	153	102	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK	101	73	All SZGR 2.0 genes in this pathway
OHM METHYLATED IN ADULT CANCERS	27	23	All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS UP	27	16	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A DN	103	71	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
BMYB多态性变体的Schwab靶标	13	9	All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP	77	60	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 60 HELA	46	32	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA	164	118	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 3	28	23	All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU UP	53	37	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON	158	93	All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS	29	20	All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL CIS	75	51	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA UP	61	40	All SZGR 2.0 genes in this pathway
WILLERT WNT SIGNALING	24	13	All SZGR 2.0 genes in this pathway
LIN APC TARGETS	77	55	All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP	108	75	All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE DN	52	37	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
ROSS AML WITH AML1 ETO FUSION	76	55	All SZGR 2.0 genes in this pathway
ZHANG TARGETS OF EWSR1 FLI1 FUSION	88	68	All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY DN	22	13	All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP	50	35	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA SPIKED	22	13	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA UP	26	22	All SZGR 2.0 genes in this pathway
STAEGE EWING FAMILY TUMOR	33	22	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP	206	118	All SZGR 2.0 genes in this pathway
Lee老化小脑DN	86	66	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY UP	86	48	All SZGR 2.0 genes in this pathway
SIMBULAN PARP1 TARGETS UP	31	23	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT	51	41	All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN	64	44	All SZGR 2.0 genes in this pathway
Zhu CMV 24小时DN	91	64	All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN	128	93	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 7	51	34	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2	163	113	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN	141	92	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS	217	138	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION	88	65	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
Heller HDAC靶向由甲基化DN沉默	281	179	All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 8G	95	62	All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G	171	96	All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER UP	73	53	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP	299	167	All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP	115	80	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN	540	340	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN	274	165	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP	172	109	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN	80	66	All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP	250	168	All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1	91	75	All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS UP	112	71	All SZGR 2.0 genes in this pathway
CLIMENT BREAST CANCER COPY NUMBER UP	23	20	All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING NOT VIA ATM UP	62	29	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
Beier神经胶质瘤干细胞DN	66	42	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D CLUSTER UP	27	19	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D UP	89	62	All SZGR 2.0 genes in this pathway
Yoshimura mapk8靶向	1305	895	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP	408	276	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP	491	316	All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE	89	56	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM LOW RISK DN	30	20	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM RISK UP	24	14	All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2	356	214	All SZGR 2.0 genes in this pathway
MIKKELSEN PARTIALLY REPROGRAMMED TO PLURIPOTENCY	10	6	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
LOPEZ MESOTHELIOMA SURVIVAL OVERALL DN	16	8	All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN	251	151	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA3 UP	80	54	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 12HR DN	33	25	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 24HR DN	43	32	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 32HR DN	39	28	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 48HR DN	40	29	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13	172	107	All SZGR 2.0 genes in this pathway
SUBTIL PROGESTIN TARGETS	36	25	All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS	77	62	All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN	213	127	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP	211	131	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP	281	183	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP	430	288	All SZGR 2.0 genes in this pathway
IVANOVSKA MIR106B TARGETS	90	56	All SZGR 2.0 genes in this pathway
WIEDERSCHAIN TARGETS OF BMI1 AND PCGF2	57	39	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN	321	200	All SZGR 2.0 genes in this pathway
瓦克缺氧VHL的目标	13	11	All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF	367	231	All SZGR 2.0 genes in this pathway
DELACROIX RAR TARGETS DN	24	16	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway
BOUDOUKHA BOUND BY IGF2BP2	111	59	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	2214	2220	1A	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-1/206	1000	1006	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
mir-15/16/195/424/497	2033	2040	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
				hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	1014	1020	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-19	1778	1785	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1778	1785	1A,m8	hsa-miR-19b	ugugcaaauccaugcaaaacuga
miR-23	2171	2177	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	2171	2177	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-323	2170	2177	1A,m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-338	907	913	m8	hsa-miR-338^brain	UCCAGCAUCAGUGAUUUUGUUGA
miR-34/449	2076	2082	1A	HSA-MIR-34A^brain	UGGCAGUGUCUUAGCUGGUUGUU
				HSA-MIR-34C	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-503	1960	1967	1A,m8	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-503	1960	1967	1A,m8	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-93.hd/291-3p/294/295/302/372/373/520	1013	1019	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhereto see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.

Gene Page:CCND1