Gene Page:REV3L

Summary?
GeneID 5980
Symbol REV3L
Synonyms POLZ|REV3
Description REV3 like, DNA directed polymerase zeta catalytic subunit
Reference MIM:602776|HGNC:HGNC:9968|Ensembl:ENSG00000009413|HPRD:04145|Vega:OTTHUMG00000016318
Gene type protein-coding
Map location 6q21
Pascal p-value 3.171E-5
Sherlock p-value 0.701
Fetal beta 1.653
DMG 1 (# studies)
eGene Cerebellum
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

部分即遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg14634336 6 111804804 REV3L 8.88E-10 -0.032 1.1E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003677 DNA binding IEA -
GO:0003887 DNA-directed DNA polymerase activity TAS 9618506
GO:0016779 nucleotidyltransferase activity IEA -
GO:0016740 transferase activity IEA -
GO:0008270 zinc ion binding IEA -
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
去:0006281 DNA repair IEA -
GO:0006261 DNA-dependent DNA replication TAS 9618506
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME DNA REPAIR 112 59 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391 222 All SZGR 2.0 genes in this pathway
AKL HTLV1 INFECTION DN 68 41 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP 58 44 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
WAKASUGI HAVE ZNF143 BINDING SITES 58 33 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
考夫曼DNA修复基因 230 137 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 147 87 All SZGR 2.0 genes in this pathway
WONG IFNA2 RESISTANCE UP 16 10 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER UP 49 36 All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS DN 86 67 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR DN 101 70 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318 220 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6 153 112 All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D8 40 29 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 473 224 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP 69 46 All SZGR 2.0 genes in this pathway
好OME OVARIAN CANCER POOR SURVIVAL UP 31 22 All SZGR 2.0 genes in this pathway
好OME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN 209 137 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238 145 All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS 289 187 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275 155 All SZGR 2.0 genes in this pathway
KUMAR AUTOPHAGY NETWORK 71 46 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 797 804 1A,m8 hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-142-5p 402 409 1A,m8 hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
miR-144 798 804 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-145 912 919 1A,m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-17-5p/20/93.mr/106/519.d 401 407 1A hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-194 677 683 1A hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
miR-203.1 750 756 m8 hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-221/222 585 591 1A hsa-miR-221brain AGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brain AGCUACAUCUGGCUACUGGGUCUC
miR-25/32/92/363/367 470 476 m8 hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-29 65 71 m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-323 466 472 m8 hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-363 662 668 1A hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
miR-365 645 651 m8 hsa-miR-365 UAAUGCCCCUAAAAAUCCUUAU
miR-381 742 748 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-493-5p 188 195 1A,m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-495 675 681 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU