Gene Page:TRIM27

Summary?
GeneID 5987
Symbol TRIM27
Synonyms RFP|RNF76
Description tripartite motif containing 27
Reference MIM:602165|HGNC:HGNC:9975|Ensembl:ENSG00000204713|HPRD:15996|Vega:OTTHUMG00000031215
Gene type protein-coding
Map location 6p22
Pascal p-value 1E-12
Sherlock p-value 0.72
Fetal beta 0.756
DMG 2 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
GSMA_I Genome scan meta-analysis Psr: 0.033
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg11629443 6 28891340 TRIM27 1.53E-5 -0.512 0.015 DMG:Wockner_2014
cg26135345 6 28806907 TRIM27 4.18E-9 -0.016 2.51 e-6 DMG:Jaffe_2016
cg10162774 6 28864168 TRIM27 3.33E-8 -0.019 9.98E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL类型
snp_a-1856993 0 TRIM27 5987 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PDLIM3 0.52 0.43
PECI 0.50 0.44
CD99 0.50 0.35
DBI 0.49 0.43
NUP37 0.47 0.35
SNRPG 0.46 0.31
TEX9 0.46 0.21
EFNA4 0.45 0.35
CLIC1 0.45 0.34
RAB32 0.45 0.30
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NDRG1 -0.35 -0.40
SLCO3A1 -0.35 -0.37
AC016910.1 -0.35 -0.39
DOCK9 -0.35 -0.34
C1orf115 -0.34 -0.39
KIF16B -0.34 -0.30
SPTBN2 -0.33 -0.34
RHOU -0.33 -0.37
SPTBN1 -0.33 -0.32
DUSP7 -0.33 -0.35

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS neurite (GO term level: 8) 3078962
GO:0003677 DNA binding IEA -
GO:0005515 protein binding 新闻学会 9570750|15837424
GO:0008270 zinc ion binding IEA -
GO:0046872 metal ion binding TAS 3380101
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 10976108
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0006350 transcription IEA -
GO:0007283 spermatogenesis TAS 3380101
GO:0008283 cell proliferation TAS 2734021
GO:0045814 negative regulation of gene expression, epigenetic IDA 10976108
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005624 membrane fraction TAS 3078962
GO:0005634 nucleus IEA -
GO:0005654 nucleoplasm IDA 10976108
GO:0005737 cytoplasm IEA -
GO:0005887 integral to plasma membrane TAS 3078962
GO:0031965 nuclear membrane IDA 10976108

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BEGAIN KIAA1446 brain-enriched guanylate kinase-associated homolog (rat) Two-hybrid BioGRID 16189514
CHD4 DKFZp686E06161 | Mi-2b | Mi2-BETA chromodomain helicase DNA binding protein 4 - HPRD 14530259
DNMT1 AIM | CXXC9 | DNMT | FLJ16293 | MCMT | MGC104992 DNA (cytosine-5-)-methyltransferase 1 Two-hybrid BioGRID 16169070
EIF3E EIF3-P48 | EIF3S6 | INT6 | eIF3-p46 eukaryotic translation initiation factor 3, subunit E - HPRD 10504338
EPC1 DKFZp781P2312 | Epl1 enhancer of polycomb homolog 1 (Drosophila) - HPRD 10976108
FBF1 Alb | FBF-1 | FLJ00103 Fas (TNFRSF6) binding factor 1 Two-hybrid BioGRID 16189514
FXYD6 - FXYD domain containing ion transport regulator 6 Two-hybrid BioGRID 16169070
HDAC1 DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 histone deacetylase 1 - HPRD 14530259
MAGEA11 MAGE-11 | MAGE11 | MAGEA-11 | MGC10511 melanoma antigen family A, 11 Two-hybrid BioGRID 16189514
MCOLN1 ML4 | MLIV | MST080 | MSTP080 | TRP-ML1 | TRPM-L1 | TRPML1 mucolipin 1 Two-hybrid BioGRID 16169070
PML MYL | PP8675 | RNF71 | TRIM19 promyelocytic leukemia - HPRD,BioGRID 9570750
PRAM1 MGC39864 | PRAM-1 PML-RARA regulated adaptor molecule 1 Affinity Capture-Western
Two-hybrid		 BioGRID 9570750
TRIM11 BIA1 | RNF92 tripartite motif-containing 11 - HPRD,BioGRID 11331580
TRIM23 ARD1 | ARFD1 | RNF46 tripartite motif-containing 23 - HPRD,BioGRID 11331580
TRIM27 RFP | RNF76 tripartite motif-containing 27 Two-hybrid BioGRID 11331580
TRIM29 ATDC | FLJ36085 tripartite motif-containing 29 - HPRD,BioGRID 11331580
TRIM32 BBS11 | HT2A | LGMD2H | TATIP tripartite motif-containing 32 - HPRD,BioGRID 11331580
ZBTB16 PLZF | ZNF145 zinc finger and BTB domain containing 16 Two-hybrid BioGRID 16189514


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
CASORELLI APL SECONDARY VS DE NOVO UP 39 25 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 77 51 All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS 58 45 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176 111 All SZGR 2.0 genes in this pathway
TOMLINS PROSTATE CANCER UP 40 27 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 2 UP 17 10 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G 171 96 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS DN 187 109 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN 146 88 All SZGR 2.0 genes in this pathway