SZGR2 - Beplay体育中心

Summary？

GeneID	60
Symbol	ACTB
Synonyms	BRWS1\|PS1TP5BP1
Description	Actin，Beta
Reference	MIM：102630\|HGNC：HGNC：132\|Ensembl：ENSG00000075624\|HPRD：00032\|Vega:OTTHUMG00000023268
基因类型	蛋白质编码
Map location	7p22
Pascal p-value	0.005
Sherlock p-value	0.495
胎儿β	1.4
主持人	Myers' cis & trans
Support	结构可塑性 CompositeSet Darnell FMRP targets

Gene in Data Sources

基因集名称	基因的方法设置	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症	点击显示详细信息
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0551

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	eQTL type
RS10409262	chr19	58154954	ACTB	60		0.04		反式

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

第三节。基因本体论注释

Molecular function	去学期	证据	神经关键字	PubMed ID
去：0000166	nucleotide binding	IEA		-
去：0005515	蛋白质结合	IEA		-
去：0005515	蛋白质结合	IPI		17342765
去：0005524	ATP binding	IEA		-
GO:0005198	structural molecule activity	IEA		-
去：0005200	细胞骨架的结构成分	TAS		6202424
去：0050998	一氧化物合酶结合	IPI		17502619
Biological process	去学期	证据	神经关键字	PubMed ID
去：0007605	sensory perception of sound	IEA		-
GO:0006928	cell motion	TAS		6202424\|16130169
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0005829	细胞质	IEA		-
去：0005856	细胞骨架	IEA		-
去：0005856	细胞骨架	TAS		16130169
去：0005625	soluble fraction	IEA		-
去：0005737	cytoplasm	TAS		16130169
GO：0035267	NuA4 histone acetyltransferase complex	IDA		10966108

Section IV. Protein-protein interaction annotation

Interactors	别名b	官方全名b	实验	Source	PubMed ID
ABRA	星星	actin-binding Rho activating protein	-	HPRD	11983702
ACTB	PS1TP5BP1	Actin，Beta	亲和力捕获 - 韦斯特恩重构的复合物 Two-hybrid	Biogrid	9209005\|16189514
ACTB	PS1TP5BP1	Actin，Beta	肌动蛋白与自身相互作用以形成F-肌动蛋白。	绑定	15361876
ACTC1	ACTC \| CMD1R \| CMH11	actin, alpha, cardiac muscle 1	-	HPRD	8913639
ACTG1	行为\|ACTG \|DFNA20 \|DFNA26	actin, gamma 1	Two-hybrid	Biogrid	16189514
arpc1b	ARC41 \|p40-arc \|P41-arc	actin related protein 2/3 complex, subunit 1B, 41kDa	-	HPRD	11533442\|11721045
C20orf20	EAF7 \|FLJ10914 \|MRG15BP \|MRGBP \|URCC4	chromosome 20 open reading frame 20	-	HPRD	12963728
CCT2	99D8.1 \| CCT-beta \| CCTB \| MGC142074 \| MGC142076 \| PRO1633 \| TCP-1-beta	伴侣素含有TCP1，亚基2（beta）	-	HPRD,BioGRID	10748209\|11580269
CCT5	CCT-epsilon \| CCTE \| KIAA0098 \| TCP-1-epsilon	伴侣素含有TCP1，亚基5（Epsilon）	-	HPRD,BioGRID	11580269
CCT8	C21orf112 \| Cctq \| D21S246 \| KIAA0002 \| PRED71	chaperonin containing TCP1, subunit 8 (theta)	-	HPRD	10748209
CFL1	CFL	Cofilin 1（非肌肉）	Two-hybrid	Biogrid	16189514
CFL2	NEM7	cofilin 2(肌肉)	亲和力捕获 - 韦斯特恩 Two-hybrid	Biogrid	16189514
CIITA	C2TA \| CIITAIV \| MHC2TA \| NLRA	class II, major histocompatibility complex, transactivator	β-肌动蛋白与P-MHC2TA相互作用。	绑定	15502823
CLIC4	CLIC4L \| DKFZp566G223 \| FLJ38640 \| H1 \| MTCLIC \| huH1 \| p64H1	chloride intracellular channel 4	-	HPRD	11563969
CPNE1	COPN1 \|CPN1 \|MGC1142	美洲i	-	HPRD	12522145
CPNE2	COPN2 \| CPN2 \| DKFZp686E06199 \| MGC16924	Cocine II	-	HPRD	12522145
CPNE4	COPN4 \| CPN4 \| MGC15604	COCHINE IV	-	HPRD	12522145
DNASE1	DKFZp686H0155 \| DNL1 \| DRNI \| FLJ38093 \| FLJ44902	脱氧核糖核酸酶i	DNase1（DNase I）与ACTB（β-肌动蛋白）相互作用。	绑定	15711563
DSTN	actdp \|ADF \|BA462D18.2	destrin (actin depolymerizing factor)	Two-hybrid	Biogrid	16189514
dynll1	DLC1 \| DLC8 \| DNCL1 \| DNCLC1 \| LC8 \| LC8a \| MGC126137 \| MGC126138 \| PIN \| hdlc1	Dynein，轻链，LC8型1	-	HPRD	14760703
EMD	EDMD \| LEMD5 \| STA	emerin	-	HPRD	12670476
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	ezrin	-	HPRD	7876308
flii	FLI \| FLIL \| Fli1 \| MGC39265	无飞的我同源物（果蝇）	-	HPRD	9525888
GSN	DKFZP313L0718	gelsolin (amyloidosis, Finnish type)	-	HPRD	10945978
hnrnpu	hnrpu \|SAF-A \|U21.1	异质核核糖核蛋白U（支架附着因子A）	ACTB（β-肌动蛋白）与HNRPU（HNRNP U）相互作用。	绑定	15711563
IFI6	6-16 \|FAM14C \|g1p3 \|ifi-6-16 \|ifi616	interferon, alpha-inducible protein 6	Beta-actin interacts with p-G1P3.	绑定	15502823
LGALS13	gal13 \|plac8 \|pp13	凝集素，半乳糖苷结合，可溶性，13	-	HPRD	15009185
我的C	Bhlhe39 \|c-myc	V-myc骨髓质体病毒性癌基因同源物（禽类）	Co-purification	Biogrid	11839798
NCALD	MGC33870 \|MGC74858	neurocalcin delta	亲和力捕获 - 韦斯特恩	Biogrid	16189514
NCF1	FLJ79451 \| NCF1A \| NOXO2 \| SH3PXD1A \| p47phox	中性粒细胞胞质因子1	Far Western	Biogrid	11027608
NCF1C	SH3PXD1C	中性粒细胞胞质因子1c假基因	-	HPRD	11027608
NCF2	FLJ93058 \| NCF-2 \| NOXA2 \| P67-PHOX \| P67PHOX	中性粒细胞胞质因子2	Far Western	Biogrid	11027608
Nebl	FLJ53769 \| LNEBL \| MGC119746 \| MGC119747 \| bA56H7.1	星云	-	HPRD	10470015
nrap	-	Nebulin相关锚定蛋白	-	HPRD	9295142
OSTF1	FLJ20559 \| OSF \| SH3P2 \| bA235O14.1	osteoclast stimulating factor 1	SH3P2interacts with beta-actin.	绑定	15135048
P2RX7	MGC20089 \| P2X7	purinergic receptor P2X, ligand-gated ion channel, 7	-	HPRD	11707406
PCYT1B	cct-beta \|CTB	phosphate cytidylyltransferase 1, choline, beta	共晶结构	Biogrid	11580269
PFDN1	PDF \| PFD1	prefoldin subunit 1	-	HPRD	11535601
PFN1	-	profilin 1	-	HPRD,BioGRID	10411937
PFN2	D3S1319E \|PFL	profilin 2	-	HPRD	10600384
PLD1	-	磷脂酶D1，磷脂酰胆碱特异性	-	HPRD	11373276
PLD2	-	phospholipase D2	-	HPRD	11373276
POLR1B	FLJ10816 \|FLJ21921 \|MGC131780 \|RPA135 \|RPA2 \|RPO1-2	polymerase (RNA) I polypeptide B, 128kDa	pol I与肌动蛋白互动。	绑定	15558034
PTN	HARP \| HBGF8 \| HBNF \| NEGF1	pleiotrophin	-	HPRD	9739080
RAB8B	FLJ38125	Rab8b，Ras Oncogene家族成员	亲和力捕获 - 韦斯特恩	Biogrid	12639940
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	-	HPRD,BioGRID	11027608
RAC2	EN-7 \| Gx \| HSPC022	与RAS相关的C3肉毒纤维毒素底物2（RHO家族，小GTP结合蛋白Rac2）	-	HPRD,BioGRID	11027608
RIBIN	-	rRNA promoter binding protein	Actin interacts with rDNA.	绑定	15558034
RRN3	DKFZp566E104 \| MGC104238 \| TIFIA	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	TIF-IA与肌动蛋白相互作用。	绑定	15558034
SMARCA4	BAF190 \| BRG1 \| FLJ39786 \| SNF2 \| SNF2-BETA \| SNF2L4 \| SNF2LB \| SWI2 \| hSNF2b	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	-	HPRD,BioGRID	9845365
SMARCC2	BAF170 \| CRACC2 \| Rsc8	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	亲和力捕获 - 韦斯特恩	Biogrid	9845365
SMARCE1	BAF57	SWI/SNF相关，矩阵相关，染色质的肌动蛋白依赖性调节剂，亚家族E，成员1	亲和力捕获 - 韦斯特恩	Biogrid	9845365
SPTAN1	（alpha）ii-spectrin \|FLJ44613 \|Neas	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	-	HPRD	9209005
SPTBN2	Gtrap41 \|SCA5	spectrin, beta, non-erythrocytic 2	重构的复合物	Biogrid	11357136
SSH1	FLJ38102 \|KIAA1298 \|SSH-1	弹弓同源物1（果蝇）	重构的复合物	Biogrid	11832213
SSH2	KIAA1725 \| MGC78588 \| SSH-2	弹弓同源2（果蝇）	重构的复合物	Biogrid	11832213
synj2bp	ARIP2 \| FLJ11271 \| FLJ41973 \| OMP25	synaptojanin 2 binding protein	-	HPRD	11673475\|11696420
TANC1	KIAA1728 \| ROLSB \| TANC	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	-	HPRD	15673434
TPM2	AMCD1 \| DA1 \| DA2B \| TMSB	肌球蛋白2（beta）	-	HPRD	9108196
TPM3	FLJ41118 \|MGC14582 \|MGC3261 \|MGC72094 \|Nem1 \|OK/SW-CL.5 \|TM-5 \|TM3 \|TM30 \|TM30NM \| TPMsk3 \| TRK \| hscp30	tropomyosin 3	-	HPRD	9108196
XPO6	EXP6 \|FLJ22519 \|KIAA0370 \|RANBP20	导出6	-	HPRD	14592989

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg焦点粘附	201	138	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION	118	78	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
Kegg Vibrio霍乱感染	56	32	All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION	59	36	All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM	85	65	All SZGR 2.0 genes in this pathway
KEGG心律失常右心肌病ARVC	76	59	All SZGR 2.0 genes in this pathway
KEGG扩张心肌病	92	68	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
wnt信令	89	71	All SZGR 2.0 genes in this pathway
REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	28	15	All SZGR 2.0 genes in this pathway
反应组蛋白折叠	53	30	All SZGR 2.0 genes in this pathway
蛋白质的反应组代谢	518	242	All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤	783	507	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE DN	21	13	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR UP	55	34	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP	265	158	All SZGR 2.0 genes in this pathway
Mayburd对L663536 DN的反应	56	32	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP	211	136	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
Graessmann对MC和阿霉素DN的反应	770	415	All SZGR 2.0 genes in this pathway
Berenjeno由Rhoa DN转变	394	258	All SZGR 2.0 genes in this pathway
CAVARD LIVER CANCER MALIGNANT VS BENIGN	32	19	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 3	48	31	All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE EARLY	66	48	All SZGR 2.0 genes in this pathway
DACOSTA LOW DOSE UV RESPONSE VIA ERCC3 XPCS DN	9	6	All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP	108	66	All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP	390	236	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络	1442	892	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
RAHMAN TP53 TARGETS PHOSPHORYLATED	21	18	All SZGR 2.0 genes in this pathway
Benporath MYC带Ebox的目标	230	156	All SZGR 2.0 genes in this pathway
Petretto心脏肥大	34	26	All SZGR 2.0 genes in this pathway
Nikolsky乳腺癌7p22 Amplicon	38	27	All SZGR 2.0 genes in this pathway
Iizuka肝癌进展G1 G2 DN	25	18	All SZGR 2.0 genes in this pathway
GNATENKO PLATELET SIGNATURE	48	28	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP	87	58	All SZGR 2.0 genes in this pathway
CHEN LUNG CANCER SURVIVAL	28	22	All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST EXPRESSION	40	29	All SZGR 2.0 genes in this pathway
Magrangeas多发性骨髓瘤IgG与IgA DN	26	16	All SZGR 2.0 genes in this pathway
Flechner PBL肾脏移植OK vs捐助者	151	100	All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE UP	79	58	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
郭十六进制靶向DN	65	36	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP	412	249	All SZGR 2.0 genes in this pathway
TBH和H2O2的Weigel氧化应激	36	24	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN	141	99	All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX UP	36	27	All SZGR 2.0 genes in this pathway
胡GENOTOXIN行动直接和间接4人力资源	37	22	All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS DN	57	39	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN	148	102	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS NEONATAL	35	25	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP	244	165	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN	298	200	All SZGR 2.0 genes in this pathway
Maclachlan BRCA1靶向DN	16	12	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE UP	43	33	All SZGR 2.0 genes in this pathway
CUI TCF21目标2向上	428	266	All SZGR 2.0 genes in this pathway
敏锐的回应罗格列酮DN	106	68	All SZGR 2.0 genes in this pathway
WHITESIDE CISPLATIN RESISTANCE DN	13	9	All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP	95	64	All SZGR 2.0 genes in this pathway
Browne HCMV感染6小时	71	48	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN	96	71	All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS UP	47	31	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE	77	50	All SZGR 2.0 genes in this pathway
肺癌和内皮的钟分泌组	66	47	All SZGR 2.0 genes in this pathway
肺癌和成纤维细胞的钟分泌组	132	93	All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向	673	430	All SZGR 2.0 genes in this pathway
Martinez TP53靶向	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN	80	66	All SZGR 2.0 genes in this pathway
Labbe Wnt3a靶向	112	71	All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS UP	102	64	All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP	111	70	All SZGR 2.0 genes in this pathway
Hsiao家政基因	389	245	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2	86	50	All SZGR 2.0 genes in this pathway
YAO对孕酮簇的时间反应17	181	101	All SZGR 2.0 genes in this pathway
萨森对促性腺营养蛋白的反应	91	59	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN	88	68	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
Pilon KLF1靶向	504	321	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP	140	94	All SZGR 2.0 genes in this pathway
Johnstone Parvb目标3	430	288	All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到	1137	655	All SZGR 2.0 genes in this pathway
Dormoy Elavl1目标	17	10	All SZGR 2.0 genes in this pathway
CTBP1和SATB1的Purbey目标	87	52	All SZGR 2.0 genes in this pathway
Gobert少突胶质细胞分化DN	1080	713	All SZGR 2.0 genes in this pathway
GUO TARGETS OF IRS1 AND IRS2	98	67	All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS DN	72	52	All SZGR 2.0 genes in this pathway
斯坦纳红细胞膜基因	15	10	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	mirna seq
miRNA family	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
mir-124.1	412	418	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-145	145	152	1A，M8	HSA-MIR-145	GUCCAGUUUUCCCAGGAAUCCCUU
mir-205	500	506	M8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-486	272	278	1A	HSA-MIR-486	UCCUGUACUGAGCUGCCCCGAG
mir-544	53	59	1A	hsa-miR-544	auucugcauuuuuuagcaagu

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhere查看与大脑相关的miRNA列表。

Gene Page:ACTB