Gene Page:FASTKD5
Summary?
| GeneID | 60493 |
| Symbol | FASTKD5 |
| Synonyms | dJ1187M17.5 |
| Description | FAST kinase domains 5 |
| Reference | MIM:614272|HGNC:HGNC:25790|Ensembl:ENSG00000215251|HPRD:07813|Vega:OTTHUMG00000031727 |
| Gene type | protein-coding |
| Map location | 20p13 |
| Pascal p-value | 0.479 |
| Sherlock p-value | 0.169 |
| Fetal beta | 0.189 |
| eGene | Myers' cis & trans |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| 认为:Xu_2012 | Whole Exome Sequencing analysis | 新创4基因的突变是鉴别ified by exome sequencing of 795 samples in this study |
Section I. Genetics and epigenetics annotation
认为table
认为table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FASTKD5 | chr20 | 3128479 | G | C | NM_001267584 NM_014948 NM_021826 NM_199415 NR_038395 |
. . p.413A>G . . |
intronic intronic missense intronic intronic |
Schizophrenia | 认为:Xu_2012 |
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg03183872 | 20 | 3140552 | FASTKD5;UBOX5 | 1.554E-4 | -0.294 | 0.032 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1111986 | chr4 | 153949046 | FASTKD5 | 60493 | 0.12 | trans | ||
| rs16239 | chr17 | 37278947 | FASTKD5 | 60493 | 0.07 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| TIEN INTESTINE PROBIOTICS 24HR UP | 557 | 331 | All SZGR 2.0 genes in this pathway |
| ELVIDGE HYPOXIA DN | 146 | 94 | All SZGR 2.0 genes in this pathway |
| ELVIDGE HIF1A TARGETS UP | 67 | 40 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |