Gene Page:ROCK1

Summary?
GeneID 6093
Symbol ROCK1
Synonyms P160ROCK|ROCK-I
Description Rho associated coiled-coil containing protein kinase 1
Reference MIM:601702|HGNC:HGNC:10251|Ensembl:ENSG00000067900|HPRD:03414|Vega:OTTHUMG00000131723
Gene type protein-coding
Map location 18q11.1
Pascal p-value 0.916
Fetal beta 1.738
DMG 1 (# studies)
eGene Cortex
Myers' cis & trans
Support INTRACELLULAR SIGNAL TRANSDUCTION

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed的genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0021

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg23360087 18 18691952 ROCK1 1.48E-5 -0.726 0.015 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1507047 chr16 50932778 ROCK1 6093 0.06 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC:分皮质区域;SM:感觉-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RPS8 0.97 0.94
BTF3 0.97 0.94
RPL4 0.96 0.94
RPS6 0.96 0.95
NACA 0.95 0.94
TUT1 0.95 0.91
RPL10A 0.95 0.97
IGBP1 0.94 0.89
RPL6P10 0.94 0.93
RPS3P3 0.94 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FBXO2 -0.67 -0.71
HLA-F -0.67 -0.74
ATP10A -0.67 -0.79
AIFM3 -0.65 -0.72
ARHGAP22 -0.64 -0.71
APOL1 -0.64 -0.79
SLC6A12 -0.63 -0.79
TINAGL1 -0.63 -0.77
APOL3 -0.63 -0.79
LDHD -0.63 -0.69

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005524 ATP binding IEA -
GO:0004674 protein serine/threonine kinase activity TAS 8798490
GO:0016740 transferase activity IEA -
GO:0008270 zinc ion binding IEA -
GO:0042802 identical protein binding 新闻学会 16249185
GO:0019992 diacylglycerol binding IEA -
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0043524 negative regulation of neuron apoptosis IEA neuron (GO term level: 9) -
GO:0000910 cytokinesis IEA -
GO:0022614 membrane to membrane docking IDA 12082081
GO:0006468 protein amino acid phosphorylation TAS 10436159
GO:0007266 Rho protein signal transduction TAS 8798490
GO:0007242 intracellular signaling cascade IEA -
GO:0006915 apoptosis IEA -
GO:0030036 actin cytoskeleton organization TAS 10436159
GO:0050901 leukocyte tethering or rolling IDA 12082081
GO:0050900 leukocyte migration IDA 12082081
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000139 Golgi membrane IEA -
GO:0005794 Golgi apparatus IEA -
GO:0005829 cytosol EXP 16983089
GO:0005622 intracellular IEA -
GO:0005737 cytoplasm IEA -
GO:0016020 membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY 151 112 All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY 86 64 All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 118 78 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION 59 36 All SZGR 2.0 genes in this pathway
BIOCARTA ECM PATHWAY 24 17 All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY 38 29 All SZGR 2.0 genes in this pathway
BIOCARTA MYOSIN PATHWAY 31 22 All SZGR 2.0 genes in this pathway
BIOCARTA RHO PATHWAY 32 23 All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY 19 17 All SZGR 2.0 genes in this pathway
BIOCARTA PAR1 PATHWAY 37 28 All SZGR 2.0 genes in this pathway
SIG CHEMOTAXIS 45 37 All SZGR 2.0 genes in this pathway
SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES 35 25 All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY 82 62 All SZGR 2.0 genes in this pathway
ST GA13 PATHWAY 37 32 All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 65 54 All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY 23 17 All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY 45 33 All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY 32 26 All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 40 38 All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 57 43 All SZGR 2.0 genes in this pathway
PID THROMBIN PAR4 PATHWAY 15 11 All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY 41 32 All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY 75 53 All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY 34 29 All SZGR 2.0 genes in this pathway
PID ECADHERIN STABILIZATION PATHWAY 42 34 All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 69 57 All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 43 32 All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY 33 32 All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 40 26 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 74 56 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 32 22 All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS 68 53 All SZGR 2.0 genes in this pathway
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 27 21 All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 148 94 All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE 54 37 All SZGR 2.0 genes in this pathway
BERENJENO ROCK SIGNALING NOT VIA RHOA DN 48 34 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE IMMORTALIZED DN 31 26 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149 101 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206 136 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195 138 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION 171 102 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP 56 34 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203 130 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 12 36 18 All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA DN 23 14 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185 116 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 1HR DN 10 8 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 931 938 1A,m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 930 937 1A,m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-135 699 706 1A,m8 hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-139 538 545 1A,m8 hsa-miR-139brain UCUACAGUGCACGUGUCU
miR-145 1357 1363 1A hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/152 1414 1420 1A hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-150 653 659 1A hsa-miR-150 UCUCCCAACCCUUGUACCAGUG
miR-153 684 690 m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-182 694 700 m8 hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-190 1438 1444 m8 hsa-miR-190 UGAUAUGUUUGAUAUAUUAGGU
miR-199 1356 1362 1A hsa-miR-199a CCCAGUGUUCAGACUACCUGUUC
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-217 1330 1336 1A hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU
miR-323 1335 1341 m8 hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-33 218 224 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-335 472 478 m8 hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
miR-34/449 956 962 1A hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-493-5p 745 751 1A hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-494 631 638 1A,m8 hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
miR-496 880 886 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-539 1535 1541 1A hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU