Gene Page:RP1

Summary?
GeneID 6101
Symbol RP1
Synonyms DCDC4A|ORP1
Description retinitis pigmentosa 1 (autosomal dominant)
Reference MIM:603937|HGNC:HGNC:10263|Ensembl:ENSG00000104237|HPRD:04896|Vega:OTTHUMG00000164379
Gene type protein-coding
Map location 8q12.1
Pascal p-value 0.002

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@认为table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
RP1 chr8 55538878 T C NM_006269 . silent Schizophrenia 认为:Fromer_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26所示postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TIMM8B 0.73 0.59
RBX1 0.68 0.52
RPS10L 0.68 0.53
AC009171.1 0.68 0.51
AC010468.1 0.68 0.54
COX7A2 0.67 0.49
PFDN5 0.67 0.61
RPL10AP3 0.67 0.45
MRPS28 0.66 0.49
NDUFB7 0.65 0.36
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PLEC1 -0.49 -0.57
TECPR2 -0.46 -0.48
MYH9 -0.46 -0.48
AGPAT3 -0.45 -0.46
ZBTB47 -0.44 -0.52
FICD -0.44 -0.47
MAFK -0.44 -0.56
ACTN4 -0.42 -0.49
SYNM -0.42 -0.51
JAKMIP3 -0.42 -0.48

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LIAN LIPA TARGETS 6M 74 47 All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA 81 64 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway