SZGR2 - Beplay体育中心

Summary？

基因	6117
象征	RPA1
Synonyms	HSSB \| MST075 \| repa1 \| rf-a \| rp-a \| rpa70
Description	replication protein A1
Reference	MIM：179835\|HGNC：HGNC：10289\|Ensembl:ENSG00000132383\|HPRD:01565\|Vega：Otthumg0000000090579
基因类型	蛋白质编码
Map location	17p13.3
Pascal p-value	0.127
Sherlock p-value	0.761
DMG	1 (# studies)
主持人	元
Support	Ascano FMRP targets

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	2

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
CG02316852	17	1737342	RPA1	1.356E-4	0.259	0.031	DMG：Wockner_2014
CG22295628	17	1733433	rpa1; smyd4	1.932E-4	-0.357	0.035	DMG：Wockner_2014

第二节。转录组注释

一般基因表达（GTEX）

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
AKTIP	ft1 \|fts	AKT interacting protein	Two-hybrid	Biogrid	16169070
ASCC2	ASC1p100	activating signal cointegrator 1 complex subunit 2	Two-hybrid	Biogrid	16169070
ATR	frp1 \|mec1 \|sckl \|SCKL1	ataxia telangiectasia and Rad3 related	蛋白质肽	Biogrid	10608806
一次旅行	DKFZp762J2115 \| FLJ12343 \| MGC20625 \| MGC21482 \| MGC26740	ATR interacting protein	共定位	Biogrid	12791985
BLM	BS \|MGC126616 \|MGC131618 \|MGC131620 \|recq2 \|recql2 \|RECQL3	布卢姆综合症	生化活动共定位重构的复合物	Biogrid	10825162\|11950880 \|12181313
BRCA2	brcc2 \|FACD \|时尚\|Fad1 \|Fancb \|fancd \|FANCD1	breast cancer 2, early onset	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	12527904
C8orf30A	FLJ40907	染色体8开放阅读框30a	Two-hybrid	Biogrid	16169070
CPE	-	羧肽酶e	Two-hybrid	Biogrid	16169070
Fanca	fa \|FA-H \|FA1 \|FAA \|FACA \|法\|Fanch \|MGC75158	Fanconi贫血，互补小组A	Affinity Capture-MS	Biogrid	12973351
HELB	-	解旋酶（DNA）B	-	HPRD	12181327
KIN	BTCD \| KIN17	KIN, antigenic determinant of recA protein homolog (mouse)	共同分级	Biogrid	12754299
MCM2	BM28 \| CCNL1 \| CDCL1 \| D3S3194 \| KIAA0030 \| MGC10606 \| MITOTIN \| cdc19	微型鲜体维护复杂组件2	-	HPRD,BioGRID	12614612
MCM4	cdc21 \|cdc54 \|MGC33310 \|P1-CDC21 \|HCDC21	微型鲜体维护复杂组件4	Two-hybrid	Biogrid	12614612
MCM6	MCG40308 \|MIS5 \|P105MCM	微型鲜体维护复杂组件6	Two-hybrid	Biogrid	12614612
MCM7	CDABP0042 \| CDC47 \| MCM2 \| P1.1-MCM3 \| P1CDC47 \| P85MCM \| PNAS-146	微型鲜体维护复杂组件7	-	HPRD,BioGRID	12614612
MSH4	-	mutS homolog 4 (E. coli)	共定位	Biogrid	11950880
MUTYH	MGC4416 \|嗯	Muty同源物（大肠杆菌）	hMYH is associated in vivo with replication protein A (RPA)	绑定	11092888
MUTYH	MGC4416 \|嗯	Muty同源物（大肠杆菌）	-	HPRD,BioGRID	11092888
ORC2L	ORC2	起源识别综合体，亚基2样（酵母）	-	HPRD,BioGRID	12614612
ORC6L	ORC6	origin recognition complex, subunit 6 like (yeast)	Two-hybrid	Biogrid	12614612
PCNA	MGC8367	增殖细胞核抗原	-	HPRD,BioGRID	12171929
prkdc	DNA-PKCS \|dnapk \|DNPK1 \|hyrc \|hyrc1 \|XRCC7 \|P350	protein kinase, DNA-activated, catalytic polypeptide	-	HPRD,BioGRID	10064605
RAD51	BRCC5 \|hrad51 \|HSRAD51 \|HST16930 \|rad51a \|reca	RAD51homolog (RecA homolog, E. coli) (S. cerevisiae)	重构的复合物	Biogrid	12077133
RAD52	-	RAD52同源物（S. cerevisiae）	重构的复合物	Biogrid	12077133
rad9a	RAD9	RAD9同源物A（S。Pombe）	RAD9与RPA70相互作用。	绑定	15897895
RBM23	Caperbeta \|FLJ10482 \|MGC4458 \|pp239 \|RNPC4	RNA结合基序蛋白23	Two-hybrid	Biogrid	16169070
RPA1	HSSB \|repa1 \|RF-A \|RP-A \|RPA70	复制蛋白A1，70KDA	-	HPRD,BioGRID	11927569
RPA2	REPA2 \| RPA32	复制蛋白A2，32KDA	-	HPRD	9461578\|12754299
RPA2	REPA2 \| RPA32	复制蛋白A2，32KDA	亲和力捕获 - 韦斯特恩共晶结构	Biogrid	10064605\|11927569
RPA3	repa3	复制蛋白A3，14KDA	-	HPRD,BioGRID	9461578
RPA4	HSU24186 \| MGC120333 \| MGC120334	复制蛋白A4，34KDA	-	HPRD,BioGRID	7760808
Selenbp1	FLJ13813 \| LPSB \| SP56 \| hSBP \| hSP56	硒结合蛋白1	Two-hybrid	Biogrid	16169070
TCEA2	TFIIS	transcription elongation factor A (SII), 2	Two-hybrid	Biogrid	16169070
提示	FLJ20516	永恒的相互作用蛋白质	亲和力捕获 - 韦斯特恩共定位	Biogrid	17296725
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	肿瘤蛋白p53	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	11751427\|15489903
TP53BP1	53bp1 \|FLJ41424 \|MGC138366 \|P202	肿瘤蛋白p53binding protein 1	Affinity Capture-MS 亲和力捕获 - 韦斯特恩	Biogrid	15856006
TREX1	AGS1 \|AGS5 \|CRV \|DKFZP434J0310 \|drn3 \|herns	三个Prime维修外切酶1	-	HPRD	12791985
XPA	XP1 \| XPAC	xeroderma pigmentosum, complementation group A	-	HPRD,BioGRID	7565690

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG DNA REPLICATION	36	21	All SZGR 2.0 genes in this pathway
KEGG核苷酸切除修复	44	25	All SZGR 2.0 genes in this pathway
KEGG不匹配维修	23	14	All SZGR 2.0 genes in this pathway
KEGG HOMOLOGOUS RECOMBINATION	28	17	All SZGR 2.0 genes in this pathway
Biocarta P53Hypoxia途径	23	21	All SZGR 2.0 genes in this pathway
PID FANCONI PATHWAY	47	28	All SZGR 2.0 genes in this pathway
PID ATR途径	39	25	All SZGR 2.0 genes in this pathway
复制前复合物的反应组激活	31	16	All SZGR 2.0 genes in this pathway
Reactome减数分裂	116	81	All SZGR 2.0 genes in this pathway
反应组细胞周期	421	253	All SZGR 2.0 genes in this pathway
REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	10	All SZGR 2.0 genes in this pathway
反应组细胞周期MITOTIC	325	185	All SZGR 2.0 genes in this pathway
Reactome细胞周期检查点	124	70	All SZGR 2.0 genes in this pathway
REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	17	11	All SZGR 2.0 genes in this pathway
Reactome转录耦合ner tc ner	45	24	All SZGR 2.0 genes in this pathway
Reactome M G1过渡	81	45	All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION	112	63	All SZGR 2.0 genes in this pathway
反应组核苷酸切除修复	51	27	All SZGR 2.0 genes in this pathway
REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	14	11	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA	92	53	All SZGR 2.0 genes in this pathway
Reactome Double Strand Break修复	24	14	All SZGR 2.0 genes in this pathway
Reactome有丝分裂G1 G1 S相	137	79	All SZGR 2.0 genes in this pathway
Reactome有丝分裂M M G1相	172	98	All SZGR 2.0 genes in this pathway
Reactome DNA修复	112	59	All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE	122	80	All SZGR 2.0 genes in this pathway
Reactome全球基因组NER GG NER	35	20	All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF INCISION COMPLEX IN GG NER	23	11	All SZGR 2.0 genes in this pathway
Reactome减数分裂重组	86	62	All SZGR 2.0 genes in this pathway
REACTOME LAGGING STRAND SYNTHESIS	19	12	All SZGR 2.0 genes in this pathway
Reactome DNA复制	192	110	All SZGR 2.0 genes in this pathway
ATR的反应组激活复制应力	38	18	All SZGR 2.0 genes in this pathway
Reactome端粒维护	75	57	All SZGR 2.0 genes in this pathway
REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	10	8	All SZGR 2.0 genes in this pathway
REACTOME EXTENSION OF TELOMERES	27	17	All SZGR 2.0 genes in this pathway
REACTOME G2 M CHECKPOINTS	45	23	All SZGR 2.0 genes in this pathway
REACTOME S PHASE	109	66	All SZGR 2.0 genes in this pathway
REACTOME DNA STRAND ELONGATION	30	18	All SZGR 2.0 genes in this pathway
周炎症反应生活的DN	384	220	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病	1382	904	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
奥斯曼膀胱癌DN	406	230	All SZGR 2.0 genes in this pathway
莱茵所有糖皮质激素治疗DN	362	238	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment	536	340	All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLICON 12P11 12 UP	33	17	All SZGR 2.0 genes in this pathway
牛津拉拉对准	9	7	All SZGR 2.0 genes in this pathway
OXFORD RALB TARGETS DN	9	6	All SZGR 2.0 genes in this pathway
牛津·拉拉（Oxford Rala）和拉尔布（Ralb）的目标	10	7	All SZGR 2.0 genes in this pathway
Mohankumar TLX1靶向	414	287	All SZGR 2.0 genes in this pathway
Pujana乳腺癌点燃int网络	101	73	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT网络	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
Pujana BRCA2 PCC网络	423	265	All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC网络	779	480	All SZGR 2.0 genes in this pathway
Pujana BRCA中心网络	117	72	All SZGR 2.0 genes in this pathway
Shen Smarca2目标	424	268	All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN	76	52	All SZGR 2.0 genes in this pathway
Collis PrkDC底物	20	15	All SZGR 2.0 genes in this pathway
Kauffmann DNA修复基因	230	137	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES	147	87	All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast DN	309	206	All SZGR 2.0 genes in this pathway
Sasaki成人T细胞白血病	176	122	All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN	184	132	All SZGR 2.0 genes in this pathway
TBH和H2O2的Weigel氧化应激	36	24	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN	141	99	All SZGR 2.0 genes in this pathway
MA PITUITARY FETAL VS ADULT UP	29	21	All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN	60	42	All SZGR 2.0 genes in this pathway
Bild E2F3致癌特征	246	153	All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向	673	430	All SZGR 2.0 genes in this pathway
Martinez TP53靶向	602	364	All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向	601	369	All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上	863	514	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
对Salirasib dn的Blum响应	342	220	All SZGR 2.0 genes in this pathway
Mueller Plurinet	299	189	All SZGR 2.0 genes in this pathway
霍夫曼大到小淋巴细胞向上	163	102	All SZGR 2.0 genes in this pathway
霍夫曼不成熟到成熟的B淋巴细胞	43	34	All SZGR 2.0 genes in this pathway
Ferrando Hox11邻居	23	13	All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN	42	29	All SZGR 2.0 genes in this pathway
Ishida E2F目标	53	27	All SZGR 2.0 genes in this pathway
Boyault肝癌子类G1 UP	113	70	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER WITH BRCA1 MUTATED UP	56	27	All SZGR 2.0 genes in this pathway
开罗肝母细胞瘤	207	143	All SZGR 2.0 genes in this pathway
Chicas RB1靶向衰老	572	352	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到	1137	655	All SZGR 2.0 genes in this pathway
Lee BMP2靶向DN	882	538	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN	553	343	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway

Gene Page:RPA1