Gene Page:RPA2

Summary?
GeneID 6118
Symbol RPA2
Synonyms REPA2|RP-A p32|RP-A p34|RPA32
Description replication protein A2
Reference MIM:179836|HGNC:HGNC:10290|Ensembl:ENSG00000117748|HPRD:01566|Vega:OTTHUMG00000003915
Gene type protein-coding
Map location 1p35
Pascal p-value 0.137
Sherlock p-value 0.303
Fetal beta 0.453
DMG 2 (# studies)
eGene Anterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg26339992 1 28241106 RPA2 1.78E-6 -0.402 0.008 DMG:Wockner_2014
cg09844983 1 28240714 RPA2 6.04E-10 -0.016 9.07E-7 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs8079075 chr17 38010814 RPA2 6118 0.18 trans
rs17185038 1 28219658 RPA2 ENSG00000117748.5 1.51449E-8 0.01 21599 gtex_brain_ba24
rs17185052 1 28241083 RPA2 ENSG00000117748.5 2.53049E-7 0.01 174 gtex_brain_ba24
rs28904914 1 28217354 RPA2 ENSG00000117748.5 1.04024E-6 0 23903 gtex_brain_putamen_basal
rs17185038 1 28219658 RPA2 ENSG00000117748.5 3.27453E-10 0 21599 gtex_brain_putamen_basal
rs17257252 1 28220484 RPA2 ENSG00000117748.5 1.04024E-6 0 20773 gtex_brain_putamen_basal
rs17185052 1 28241083 RPA2 ENSG00000117748.5 2.23183E-9 0 174 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
POLR2I 0.88 0.81
SSNA1 0.85 0.78
POLR2L 0.85 0.78
TCEB2 0.84 0.74
DGCR6L 0.84 0.80
FAM128B 0.83 0.71
RABAC1 0.82 0.76
C16orf13 0.82 0.76
GAMT 0.82 0.74
TIMM13 0.82 0.74
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FLT1 -0.36 -0.35
SDPR -0.36 -0.33
NFAT5 -0.33 -0.27
LRP1B -0.33 -0.27
MYSM1 -0.33 -0.26
COBLL1 -0.33 -0.26
MAN2A1 -0.33 -0.30
PLCL1 -0.32 -0.28
FMNL2 -0.32 -0.28
VPS13C -0.32 -0.25

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ACP5 MGC117378 | TRAP acid phosphatase 5, tartrate resistant Two-hybrid BioGRID 16169070
C1orf103 FLJ11269 | RIF1 | RP11-96K19.1 chromosome 1 open reading frame 103 Two-hybrid BioGRID 16169070
C7orf64 DKFZP564O0523 | DKFZp686D1651 | HSPC304 chromosome 7 open reading frame 64 Two-hybrid BioGRID 16169070
CCNO CCNU | FLJ22422 | UDG2 | UNG2 cyclin O - HPRD,BioGRID 10393198|11081631|11081631
CDC2 CDC28A | CDK1 | DKFZp686L20222 | MGC111195 cell division cycle 2, G1 to S and G2 to M - HPRD 1318195
COPS6 CSN6 | MOV34-34KD COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) Two-hybrid BioGRID 16169070
CREBBP CBP | KAT3A | RSTS CREB binding protein Affinity Capture-Western BioGRID 17525332
CRMP1 DPYSL1 | DRP-1 | DRP1 collapsin response mediator protein 1 Two-hybrid BioGRID 16169070
EEF1A1 CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1 eukaryotic translation elongation factor 1 alpha 1 Two-hybrid BioGRID 16169070
GAPDH G3PD | GAPD | MGC88685 glyceraldehyde-3-phosphate dehydrogenase Two-hybrid BioGRID 16169070
GOLM1 C9orf155 | FLJ22634 | FLJ23608 | GOLPH2 | GP73 | PSEC0257 | bA379P1.3 golgi membrane protein 1 Two-hybrid BioGRID 16169070
HERPUD1 HERP | KIAA0025 | Mif1 | SUP homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 Two-hybrid BioGRID 16169070
HUS1 - HUS1 checkpoint homolog (S. pombe) Hus1 interacts with RPA32. BIND 15897895
KIAA1377 - KIAA1377 Two-hybrid BioGRID 16169070
KIN BTCD | KIN17 KIN, antigenic determinant of recA protein homolog (mouse) Co-fractionation BioGRID 12754299
MCM2 BM28 | CCNL1 | CDCL1 | D3S3194 | KIAA0030 | MGC10606 | MITOTIN | cdc19 minichromosome maintenance complex component 2 - HPRD,BioGRID 12614612
MCM3 HCC5 | MGC1157 | P1-MCM3 | P1.h | RLFB minichromosome maintenance complex component 3 Two-hybrid BioGRID 12614612
MCM4 CDC21 | CDC54 | MGC33310 | P1-CDC21 | hCdc21 minichromosome maintenance complex component 4 Two-hybrid BioGRID 12614612
MCM5 CDC46 | MGC5315 | P1-CDC46 minichromosome maintenance complex component 5 Two-hybrid BioGRID 12614612
MED31 3110004H13Rik | CGI-125 | FLJ27436 | FLJ36714 | Soh1 mediator complex subunit 31 Two-hybrid BioGRID 16169070
MEN1 MEAI | SCG2 multiple endocrine neoplasia I - HPRD,BioGRID 12509449
ORC1L HSORC1 | ORC1 | PARC1 origin recognition complex, subunit 1-like (yeast) Two-hybrid BioGRID 12614612
ORC2L ORC2 origin recognition complex, subunit 2-like (yeast) - HPRD,BioGRID 12614612
ORC4L ORC4 | ORC4P origin recognition complex, subunit 4-like (yeast) Two-hybrid BioGRID 12614612
ORC5L ORC5 | ORC5P | ORC5T origin recognition complex, subunit 5-like (yeast) Two-hybrid BioGRID 12614612
PRKDC DNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350 protein kinase, DNA-activated, catalytic polypeptide DNA-PKcs interacts with RPA2. BIND 11000264
PRKDC DNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350 protein kinase, DNA-activated, catalytic polypeptide - HPRD,BioGRID 10064605|11731442
RAD1 HRAD1 | REC1 RAD1 homolog (S. pombe) An unspecified isoform of Rad1 interacts with RPA32. BIND 15897895
RAD52 - RAD52同族体(酵母) Affinity Capture-Western BioGRID 12139939
RAD9A RAD9 RAD9 homolog A (S. pombe) Rad9 interacts with RPA32. BIND 15897895
RPA1 HSSB | REPA1 | RF-A | RP-A | RPA70 replication protein A1, 70kDa - HPRD 9461578|12754299
RPA1 HSSB | REPA1 | RF-A | RP-A | RPA70 replication protein A1, 70kDa Affinity Capture-Western
Co-crystal Structure		 BioGRID 10064605|11927569
RPA3 REPA3 replication protein A3, 14kDa Co-crystal Structure
Co-purification		 BioGRID 9461578|11927569
RPA3 REPA3 replication protein A3, 14kDa - HPRD 9461578|11173472|11081631
RPA4 HSU24186 | MGC120333 | MGC120334 replication protein A4, 34kDa Affinity Capture-Western
Two-hybrid		 BioGRID 7760808
RPLP1 FLJ27448 | MGC5215 | P1 | RPP1 ribosomal protein, large, P1 Two-hybrid BioGRID 16169070
SERTAD3 RBT1 SERTA domain containing 3 - HPRD,BioGRID 10982866
STAT3 APRF | FLJ20882 | HIES | MGC16063 signal transducer and activator of transcription 3 (acute-phase response factor) - HPRD,BioGRID 10875894
TLE1 ESG | ESG1 | GRG1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) Two-hybrid BioGRID 16169070
TP53BP1 53BP1 | FLJ41424 | MGC138366 | p202 tumor protein p53 binding protein 1 Affinity Capture-MS
Affinity Capture-Western		 BioGRID 15856006
TUBB2A TUBB | TUBB2 | dJ40E16.7 tubulin, beta 2A Two-hybrid BioGRID 16169070
UNC119 HRG4 unc-119 homolog (C. elegans) Two-hybrid BioGRID 16169070
UNG DGU | DKFZp781L1143 | HIGM4 | UDG | UNG1 | UNG15 | UNG2 uracil-DNA glycosylase - HPRD,BioGRID 9045683
UTP14A KIAA0266 | NY-CO-16 | SDCCAG16 | dJ537K23.3 UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) Two-hybrid BioGRID 16169070
XPA XP1 | XPAC xeroderma pigmentosum, complementation group A - HPRD,BioGRID 7565690|11081631|11081631
XRCC6 CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAA X-ray repair complementing defective repair in Chinese hamster cells 6 Affinity Capture-Western BioGRID 10064605


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG DNA REPLICATION 36 21 All SZGR 2.0 genes in this pathway
KEGG NUCLEOTIDE EXCISION REPAIR 44 25 All SZGR 2.0 genes in this pathway
KEGG MISMATCH REPAIR 23 14 All SZGR 2.0 genes in this pathway
KEGG HOMOLOGOUS RECOMBINATION 28 17 All SZGR 2.0 genes in this pathway
PID FANCONI PATHWAY 47 28 All SZGR 2.0 genes in this pathway
PID ATR PATHWAY 39 25 All SZGR 2.0 genes in this pathway
REACTOME活性ATION OF THE PRE REPLICATIVE COMPLEX 31 16 All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS 116 81 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 10 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS 124 70 All SZGR 2.0 genes in this pathway
REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS 17 11 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION COUPLED NER TC NER 45 24 All SZGR 2.0 genes in this pathway
REACTOME M G1 TRANSITION 81 45 All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 112 63 All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE EXCISION REPAIR 51 27 All SZGR 2.0 genes in this pathway
REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER 14 11 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA 92 53 All SZGR 2.0 genes in this pathway
REACTOME DOUBLE STRAND BREAK REPAIR 24 14 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 137 79 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 172 98 All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR 112 59 All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE 122 80 All SZGR 2.0 genes in this pathway
REACTOME GLOBAL GENOMIC NER GG NER 35 20 All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF INCISION COMPLEX IN GG NER 23 11 All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC RECOMBINATION 86 62 All SZGR 2.0 genes in this pathway
REACTOME LAGGING STRAND SYNTHESIS 19 12 All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192 110 All SZGR 2.0 genes in this pathway
REACTOME活性ATION OF ATR IN RESPONSE TO REPLICATION STRESS 38 18 All SZGR 2.0 genes in this pathway
REACTOME TELOMERE MAINTENANCE 75 57 All SZGR 2.0 genes in this pathway
REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND 10 8 All SZGR 2.0 genes in this pathway
REACTOME EXTENSION OF TELOMERES 27 17 All SZGR 2.0 genes in this pathway
REACTOME G2 M CHECKPOINTS 45 23 All SZGR 2.0 genes in this pathway
REACTOME S PHASE 109 66 All SZGR 2.0 genes in this pathway
REACTOME DNA STRAND ELONGATION 30 18 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
SLEBOS HEAD AND NECK CANCER WITH HPV UP 84 43 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
AMUNDSON GENOTOXIC SIGNATURE 105 68 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 101 73 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209 139 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230 137 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 147 87 All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS UP 50 30 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP 63 48 All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP 203 135 All SZGR 2.0 genes in this pathway
APRELIKOVA BRCA1 TARGETS 49 33 All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 77 57 All SZGR 2.0 genes in this pathway
KALMA E2F1 TARGETS 11 7 All SZGR 2.0 genes in this pathway
LOPES METHYLATED IN COLON CANCER DN 28 26 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP 111 70 All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A DN 159 105 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP 84 60 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277 166 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335 193 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 162 86 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414 237 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 107 72 All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 6HR 85 49 All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR 128 73 All SZGR 2.0 genes in this pathway