Gene Page:RPL6

Summary?
GeneID 6128
Symbol RPL6
Synonyms L6|SHUJUN-2|TAXREB107|TXREB1
Description ribosomal protein L6
Reference MIM:603703|HGNC:HGNC:10362|Ensembl:ENSG00000089009|HPRD:04745|Vega:OTTHUMG00000169685
Gene type protein-coding
Map location 12q24.1
Pascal p-value 0.139
Sherlock p-value 0.4
Fetal beta 1.023
DMG 1 (# studies)
eGene Myers' cis & trans
Support RNA AND PROTEIN SYNTHESIS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25689940 12 112847715 RPL6 3.438E-4 0.587 0.041 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
snp_a-2162733 0 RPL6 6128 0.18 trans
rs9933246 chr16 7497701 RPL6 6128 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RPL27 0.93 0.90
PFDN5 0.92 0.95
RPL35 0.91 0.88
RPS23 0.90 0.92
RPS20 0.90 0.91
RPL34 0.90 0.90
RPL24 0.90 0.89
RPS15A 0.89 0.90
RPS21 0.88 0.94
RPS3AP47 0.88 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SYNM -0.61 -0.77
SEMA3G -0.59 -0.72
PK4P -0.58 -0.67
SLC20A2 -0.58 -0.70
PTPRB -0.58 -0.71
COBLL1 -0.58 -0.69
RRBP1 -0.58 -0.73
TNS1 -0.57 -0.75
ZBTB47 -0.56 -0.64
EPAS1 -0.56 -0.76

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG RIBOSOME 88 43 All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION 222 75 All SZGR 2.0 genes in this pathway
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 179 53 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE CHAIN ELONGATION 153 41 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518 242 All SZGR 2.0 genes in this pathway
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 176 51 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE 203 72 All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 169 47 All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 176 57 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP 121 71 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
PARK HSC VS MULTIPOTENT PROGENITORS DN 18 12 All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN 85 56 All SZGR 2.0 genes in this pathway
BHATTACHARYA EMBRYONIC STEM CELL 89 60 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT 51 41 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165 106 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
FLOTHO PEDIATRIC ALL THERAPY RESPONSE UP 53 33 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 89 56 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 181 97 All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER WITH EPCAM UP 53 25 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
BILANGES SERUM AND RAPAMYCIN SENSITIVE GENES 68 35 All SZGR 2.0 genes in this pathway
BILANGES SERUM RESPONSE TRANSLATION 37 20 All SZGR 2.0 genes in this pathway
HOLLEMAN ASPARAGINASE RESISTANCE B ALL UP 26 15 All SZGR 2.0 genes in this pathway
HOLLEMAN ASPARAGINASE RESISTANCE ALL UP 22 14 All SZGR 2.0 genes in this pathway