Gene Page:BCR
Summary？
| GeneID | 613 |
| Symbol | BCR |
| Synonyms | ALL|BCR1|CML|D22S11|D22S662|PHL |
| Description | breakpoint cluster region |
| Reference | MIM:151410|HGNC:HGNC:1014|Ensembl:ENSG00000186716|HPRD:01044|Vega:OTTHUMG00000150655 |
| 基因类型 | 蛋白质编码 |
| Map location | 22q11.23 |
| Pascal p-value | 0.773 |
| Sherlock p-value | 0.524 |
| 胎儿β | -0.386 |
| 主持人 | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere 小脑 Cortex Frontal Cortex BA9 海马 Hypothalamus 伏隔核基底神经节 Putamen basal ganglia Meta |
| Support | G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets Ascano FMRP targets |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.031 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | 点击显示详细信息 |
| GO_Annotation | 将与神经相关的关键字映射到基因本体论注释 | Hits with neuro-related keywords: 1 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | PPI网络中最短路径的贡献：0.1296 |
Section I. Genetics and epigenetics annotation
情商TL annotation
情商TL annotation| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | pvalue | QVALUE | TSS距离 | 情商TL type |
|---|---|---|---|---|---|---|---|---|
| rs131684 | 22 | 23646257 | BCR | ENSG00000186716.15 | 1.785E-8 | 0 | 124366 | gtex_brain_ba24 |
| RS140507 | 22 | 23646512 | BCR | ENSG00000186716.15 | 1.785E-8 | 0 | 124621 | gtex_brain_ba24 |
| rs131686 | 22 | 23646953 | BCR | ENSG00000186716.15 | 1.785E-8 | 0 | 125062 | gtex_brain_ba24 |
| rs131689 | 22 | 23647845 | BCR | ENSG00000186716.15 | 1.788E-7 | 0 | 125954 | gtex_brain_ba24 |
| rs131690 | 22 | 23648009 | BCR | ENSG00000186716.15 | 1.786E-8 | 0 | 126118 | gtex_brain_ba24 |
| rs131691 | 22 | 23648625 | BCR | ENSG00000186716.15 | 1.51E-8 | 0 | 126734 | gtex_brain_ba24 |
| RS140508 | 22 | 23648913 | BCR | ENSG00000186716.15 | 1.785E-7 | 0 | 127022 | gtex_brain_ba24 |
| rs131693 | 22 | 23649242 | BCR | ENSG00000186716.15 | 1.796E-8 | 0 | 127351 | gtex_brain_ba24 |
| rs149904420 | 22 | 23649868 | BCR | ENSG00000186716.15 | 3.245e-8 | 0 | 127977 | gtex_brain_ba24 |
| rs28405226 | 22 | 23649994 | BCR | ENSG00000186716.15 | 1.225E-8 | 0 | 128103 | gtex_brain_ba24 |
| RS131703 | 22 | 23652201 | BCR | ENSG00000186716.15 | 1.294E-7 | 0 | 130310 | gtex_brain_ba24 |
| RS140509 | 22 | 23652212 | BCR | ENSG00000186716.15 | 1.299E-7 | 0 | 130321 | gtex_brain_ba24 |
| rs180797 | 22 | 23652956 | BCR | ENSG00000186716.15 | 1.944E-7 | 0 | 131065 | gtex_brain_ba24 |
| rs180801 | 22 | 23653880 | BCR | ENSG00000186716.15 | 1.246E-7 | 0 | 131989 | gtex_brain_ba24 |
| rs180805 | 22 | 23654993 | BCR | ENSG00000186716.15 | 5.211E-8 | 0 | 133102 | gtex_brain_ba24 |
| rs180806 | 22 | 23655219 | BCR | ENSG00000186716.15 | 1.317E-7 | 0 | 133328 | gtex_brain_ba24 |
| rs180810 | 22 | 23657477 | BCR | ENSG00000186716.15 | 1.273E-7 | 0 | 135586 | gtex_brain_ba24 |
| rs180811 | 22 | 23657495 | BCR | ENSG00000186716.15 | 1.371E-6 | 0 | 135604 | gtex_brain_ba24 |
| rs180812 | 22 | 23657735 | BCR | ENSG00000186716.15 | 1.457E-7 | 0 | 135844 | gtex_brain_ba24 |
| rs392389 | 22 | 23657874 | BCR | ENSG00000186716.15 | 1.507E-7 | 0 | 135983 | gtex_brain_ba24 |
| rs440531 | 22 | 23657875 | BCR | ENSG00000186716.15 | 1.507E-7 | 0 | 135984 | gtex_brain_ba24 |
| rs113629387 | 22 | 23657939 | BCR | ENSG00000186716.15 | 5.657E-7 | 0 | 136048 | gtex_brain_ba24 |
| rs28379041 | 22 | 23657966 | BCR | ENSG00000186716.15 | 1.469E-7 | 0 | 136075 | gtex_brain_ba24 |
| rs180816 | 22 | 23657980 | BCR | ENSG00000186716.15 | 1.29E-7 | 0 | 136089 | gtex_brain_ba24 |
| rs180817 | 22 | 23658007 | BCR | ENSG00000186716.15 | 1.182E-7 | 0 | 136116 | gtex_brain_ba24 |
| rs201326729 | 22 | 23662657 | BCR | ENSG00000186716.15 | 5.284e-7 | 0 | 140766 | gtex_brain_ba24 |
| rs12163260 | 22 | 23662671 | BCR | ENSG00000186716.15 | 5.636E-8 | 0 | 140780 | gtex_brain_ba24 |
| rs4632463 | 22 | 23662897 | BCR | ENSG00000186716.15 | 5.757E-7 | 0 | 141006 | gtex_brain_ba24 |
| rs4822384 | 22 | 23663848 | BCR | ENSG00000186716.15 | 2.012E-7 | 0 | 141957 | gtex_brain_ba24 |
| rs131684 | 22 | 23646257 | BCR | ENSG00000186716.15 | 6.52E-8 | 0 | 124366 | gtex_brain_putamen_basal |
| RS140507 | 22 | 23646512 | BCR | ENSG00000186716.15 | 5.125E-8 | 0 | 124621 | gtex_brain_putamen_basal |
| rs131686 | 22 | 23646953 | BCR | ENSG00000186716.15 | 3.399E-8 | 0 | 125062 | gtex_brain_putamen_basal |
| rs131689 | 22 | 23647845 | BCR | ENSG00000186716.15 | 6.637E-8 | 0 | 125954 | gtex_brain_putamen_basal |
| rs131690 | 22 | 23648009 | BCR | ENSG00000186716.15 | 1.56E-8 | 0 | 126118 | gtex_brain_putamen_basal |
| rs131691 | 22 | 23648625 | BCR | ENSG00000186716.15 | 1.37E-8 | 0 | 126734 | gtex_brain_putamen_basal |
| RS140508 | 22 | 23648913 | BCR | ENSG00000186716.15 | 6.63E-8 | 0 | 127022 | gtex_brain_putamen_basal |
| rs131693 | 22 | 23649242 | BCR | ENSG00000186716.15 | 1.505E-8 | 0 | 127351 | gtex_brain_putamen_basal |
| rs149904420 | 22 | 23649868 | BCR | ENSG00000186716.15 | 4.142E-8 | 0 | 127977 | gtex_brain_putamen_basal |
| rs28405226 | 22 | 23649994 | BCR | ENSG00000186716.15 | 1.377E-8 | 0 | 128103 | gtex_brain_putamen_basal |
| RS131703 | 22 | 23652201 | BCR | ENSG00000186716.15 | 8.154e-13 | 0 | 130310 | gtex_brain_putamen_basal |
| RS140509 | 22 | 23652212 | BCR | ENSG00000186716.15 | 8.101E-13 | 0 | 130321 | gtex_brain_putamen_basal |
| rs180797 | 22 | 23652956 | BCR | ENSG00000186716.15 | 1.237E-12 | 0 | 131065 | gtex_brain_putamen_basal |
| rs180801 | 22 | 23653880 | BCR | ENSG00000186716.15 | 1.153E-12 | 0 | 131989 | gtex_brain_putamen_basal |
| RS56024092 | 22 | 23654807 | BCR | ENSG00000186716.15 | 1.382E-6 | 0 | 132916 | gtex_brain_putamen_basal |
| rs180805 | 22 | 23654993 | BCR | ENSG00000186716.15 | 1.233E-12 | 0 | 133102 | gtex_brain_putamen_basal |
| rs11558697 | 22 | 23655084 | BCR | ENSG00000186716.15 | 1.155E-6 | 0 | 133193 | gtex_brain_putamen_basal |
| rs180806 | 22 | 23655219 | BCR | ENSG00000186716.15 | 3.123E-12 | 0 | 133328 | gtex_brain_putamen_basal |
| rs66569843 | 22 | 23656148 | BCR | ENSG00000186716.15 | 1.109E-6 | 0 | 134257 | gtex_brain_putamen_basal |
| rs180809 | 22 | 23657326 | BCR | ENSG00000186716.15 | 5.684E-8 | 0 | 135435 | gtex_brain_putamen_basal |
| rs180810 | 22 | 23657477 | BCR | ENSG00000186716.15 | 2.953E-9 | 0 | 135586 | gtex_brain_putamen_basal |
| rs180811 | 22 | 23657495 | BCR | ENSG00000186716.15 | 8.444E-11 | 0 | 135604 | gtex_brain_putamen_basal |
| rs180812 | 22 | 23657735 | BCR | ENSG00000186716.15 | 3.142E-12 | 0 | 135844 | gtex_brain_putamen_basal |
| rs392389 | 22 | 23657874 | BCR | ENSG00000186716.15 | 3.057E-12 | 0 | 135983 | gtex_brain_putamen_basal |
| rs440531 | 22 | 23657875 | BCR | ENSG00000186716.15 | 3.057E-12 | 0 | 135984 | gtex_brain_putamen_basal |
| rs113629387 | 22 | 23657939 | BCR | ENSG00000186716.15 | 3.868e-12 | 0 | 136048 | gtex_brain_putamen_basal |
| rs28379041 | 22 | 23657966 | BCR | ENSG00000186716.15 | 1.227E-8 | 0 | 136075 | gtex_brain_putamen_basal |
| rs180816 | 22 | 23657980 | BCR | ENSG00000186716.15 | 6.116E-9 | 0 | 136089 | gtex_brain_putamen_basal |
| rs180817 | 22 | 23658007 | BCR | ENSG00000186716.15 | 1.91E-11 | 0 | 136116 | gtex_brain_putamen_basal |
| RS2330350 | 22 | 23660942 | BCR | ENSG00000186716.15 | 1.58E-8 | 0 | 139051 | gtex_brain_putamen_basal |
| rs13057338 | 22 | 23660980 | BCR | ENSG00000186716.15 | 2.706E-10 | 0 | 139089 | gtex_brain_putamen_basal |
| RS9612293 | 22 | 23661273 | BCR | ENSG00000186716.15 | 1.232E-9 | 0 | 139382 | gtex_brain_putamen_basal |
| rs201326729 | 22 | 23662657 | BCR | ENSG00000186716.15 | 1.815E-9 | 0 | 140766 | gtex_brain_putamen_basal |
| rs12163260 | 22 | 23662671 | BCR | ENSG00000186716.15 | 7.83E-10 | 0 | 140780 | gtex_brain_putamen_basal |
| rs4632463 | 22 | 23662897 | BCR | ENSG00000186716.15 | 6.085e-10 | 0 | 141006 | gtex_brain_putamen_basal |
| rs8140083 | 22 | 23663722 | BCR | ENSG00000186716.15 | 1.471E-10 | 0 | 141831 | gtex_brain_putamen_basal |
| RS13053509 | 22 | 23663772 | BCR | ENSG00000186716.15 | 9.671E-7 | 0 | 141881 | gtex_brain_putamen_basal |
| rs4822384 | 22 | 23663848 | BCR | ENSG00000186716.15 | 9.318E-10 | 0 | 141957 | gtex_brain_putamen_basal |
第二节。转录组注释
一般基因表达（GTEX）
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。
No co-expressed genes in brain regions
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| GO:0005089 | Rho鸟苷核苷酸交换因子活性 | IEA | - | |
| GO:0005085 | 鸟苷核苷酸交换因子活性 | IEA | - | |
| GO:0005096 | GTPase激活剂活性 | nas | - | |
| GO:0005096 | GTPase激活剂活性 | TAS | 1903516 | |
| 去：0004674 | protein serine/threonine kinase activity | nas | - | |
| 去：0004674 | protein serine/threonine kinase activity | TAS | 1657398 | |
| GO：0016740 | transferase activity | IEA | - | |
| 去：0016301 | kinase activity | IEA | - | |
| Biological process | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0007420 | brain development | IEA | 大脑（GO期限：7） | - |
| GO:0006468 | 蛋白质磷酸化氨基酸 | TAS | 1657398 | |
| GO:0007242 | 细胞内信号传导级联 | IEA | - | |
| GO:0007242 | 细胞内信号传导级联 | nas | - | |
| GO：0035023 | 调节Rho蛋白信号转导的调节 | IEA | - | |
| GO：0051726 | regulation of cell cycle | IEA | - | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0005575 | cellular_component | ND | - | |
| 去：0005622 | 细胞内 | IEA | - |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL |JTK7 |BCR/ABL |c-abl |P150 |V-ABL | C-ABL癌基因1，受体酪氨酸激酶 | BCR与C-ABL相互作用。这种相互作用是在未指定源和人C-ABL的BCR之间证明的相互作用上建模的。 | 绑定 | 1383690 |
| ABL1 | ABL |JTK7 |BCR/ABL |c-abl |P150 |V-ABL | C-ABL癌基因1，受体酪氨酸激酶 | - | HPRD | 11780146 |
| ABL1 | ABL |JTK7 |BCR/ABL |c-abl |P150 |V-ABL | C-ABL癌基因1，受体酪氨酸激酶 | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 1712671|8112292 |12543778 |
| ABL2 | ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441 | V-ABLAbelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | BCR与ARG相互作用。这种相互作用是根据来自未指定的来源和人类ARG的BCR之间的相互作用进行了建模的。 | 绑定 | 1383690 |
| BCR | 全部|BCR-ABL1 |BCR1 |CML |D22S11 |D22S662 |FLJ16453 |phl | breakpoint cluster region | - | HPRD | 11780146 |
| BCR | 全部|BCR-ABL1 |BCR1 |CML |D22S11 |D22S662 |FLJ16453 |phl | breakpoint cluster region | p210 Bcr-Abl phosphorylates p160 Bcr. | 绑定 | 8112292 |
| BLK | MGC10442 | B淋巴酪氨酸激酶 | - | HPRD | 8756631 |
| CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | Co-purification | Biogrid | 8641358 |
| CRKL | - | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 亲和力捕获 - 韦斯特恩 Far Western Two-hybrid |
Biogrid | 8978305|9747873 |10194128|15143164 |
| ERCC3 | BTF2 |GTF2H |rad25 |tfiih |XPB | 切除修复交叉补充的啮齿动物修复缺陷，互补组3（Xeroderma色素组B组补充） | - | HPRD, BioGRID | 9874796 |
| FES | FPS | feline sarcoma oncogene | - | HPRD, BioGRID | 7529874 |
| GAB2 | KIAA0571 | GRB2-associated binding protein 2 | 亲和力捕获 - 韦斯特恩 | Biogrid | 15143164 |
| GRB10 | grb-ir |GRB-10 |IRBP |KIAA0207 |MEG1 |RSS | growth factor receptor-bound protein 10 | - | HPRD, BioGRID | 9747873 |
| GRB2 | 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 | growth factor receptor-bound protein 2 | Grb2 interacts with Bcr-Abl. | 绑定 | 9872323 |
| GRB2 | 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 | growth factor receptor-bound protein 2 | - | HPRD, BioGRID | 8112292|9178913 |
| GRB2 | 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 | growth factor receptor-bound protein 2 | Tyrosine phosphorylated Bcr-Abl interacts with Grb2. | 绑定 | 8112292 |
| HCK | JTK9 | 血压细胞激酶 | 亲和力捕获 - 韦斯特恩 | Biogrid | 10849448|12592324 |
| Hoxa9 | ABD-B | HOX1 | HOX1.7 | HOX1G | MGC1934 | homeobox A9 | Phenotypic Enhancement | Biogrid | 12393433 |
| IGSF21 | FLJ41177 |MGC15730 | 免疫球蛋白超家族，成员21 | Two-hybrid | Biogrid | 16169070 |
| JAK2 | JTK10 | Janus kinase 2 (a protein tyrosine kinase) | - | HPRD, BioGRID | 12023981|12370803 |
| KIT | c-kit |CD117 |PBT |scfr | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 亲和力捕获 - 韦斯特恩 | Biogrid | 8757502 |
| MAP4K5 | GCKR | KHS | KHS1 | MAPKKKK5 | 有丝分裂原激活的蛋白激酶激酶激酶激酶5 | - | HPRD | 9949177 |
| MLLT4 | AF-6 |AF6 |Afadin |FLJ34371 |RP3-431P23.3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | - | HPRD, BioGRID | 12808105 |
| NCK2 | grb4 |NCKBETA | NCK adaptor protein 2 | - | HPRD | 10887126 |
| pik3cg | PI3CG | PI3K | PI3Kgamma | PIK3 | 磷酸肌醇3-激酶，催化，伽马多肽 | 亲和力捕获 - 韦斯特恩 Co-purification Two-hybrid |
Biogrid | 7606002|8641358 |9747873 |
| PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | BCRinteracts with PLCgamma1. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and bovine PLCgamma1. | 绑定 | 1383690 |
| PTPN11 | bptp3 |CFC |MGC14433 |NS1 |PTP-1D |PTP2C |SH-PTP2 |sh-ptp3 |SHP2 | protein tyrosine phosphatase, non-receptor type 11 | Phosphorylated p210bcr-abl interacts with phosphorylated Syp. This interaction was modeled on a demonstrated interaction between human p210bcr-abl and mouse Syp. | 绑定 | 8195176 |
| PTPN11 | bptp3 |CFC |MGC14433 |NS1 |PTP-1D |PTP2C |SH-PTP2 |sh-ptp3 |SHP2 | protein tyrosine phosphatase, non-receptor type 11 | - | HPRD | 12115002 |
| PTPN6 | HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1 | 蛋白质酪氨酸磷酸酶，非受体6型 | - | HPRD, BioGRID | 9211920 |
| PXN | FLJ16691 | paxillin | 亲和力捕获 - 韦斯特恩 Co-purification |
Biogrid | 7534286|8641358 |
| RASA1 | CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAP | RAS p21 protein activator (GTPase activating protein) 1 | BCRinteracts with GAP. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human GAP. | 绑定 | 1383690 |
| RB1 | OSRC |RB |P105-RB |PRB |PP110 | retinoblastoma 1 | 亲和力捕获 - 韦斯特恩 | Biogrid | 9071815 |
| SH2B1 | DKFZP547G1110 |FLJ30542 |KIAA1299 |SH2-B |SH2B | SH2B适配器蛋白1 | 亲和力捕获 - 韦斯特恩 | Biogrid | 12370803 |
| SHC1 | FLJ26504 | SHC | SHCA | SHC（SRC同源性2结构域）转化蛋白1 | - | HPRD, BioGRID | 9209414 |
| SOS1 | GF1 | GGF1 | GINGF | HGF | NS4 | 七个无同胞1的儿子（果蝇） | 亲和力捕获 - 韦斯特恩 | Biogrid | 8112292 |
| SRC | ASV | SRC1 | c-SRC | p60-Src | V-SRC肉瘤（Schmidt-Ruppin A-2）病毒癌基因同源物（Avian） | BCRinteracts with Src. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and Src from Rous Sarcoma virus. | 绑定 | 1383690 |
| TLN1 | ilweq |KIAA1027 |TLN | talin 1 | Co-purification | Biogrid | 8641358 |
| TP53 | FLJ92943 | LFS1 | TRP53 | p53 | 肿瘤蛋白p53 | Two-hybrid | Biogrid | 16169070 |
| UNC119 | HRG4 | unc-119 homolog (C. elegans) | Two-hybrid | Biogrid | 16169070 |
| VAV1 | VAV | vav 1 guanine nucleotide exchange factor | - | HPRD | 11790798 |
| YWHAZ | KCIP-1 |MGC111427 |MGC126532 |MGC138156 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | - | HPRD | 7939633 |
Section V. Pathway annotation
| 路径名 | 路径大小 | # SZGR 2.0 genes in pathway | 信息 |
|---|---|---|---|
| 癌症中的KEGG途径 | 328 | 259 | All SZGR 2.0 genes in this pathway |
| KEGG慢性髓细胞性白血病 | 73 | 59 | All SZGR 2.0 genes in this pathway |
| Biocarta Gleevec途径 | 23 | 17 | All SZGR 2.0 genes in this pathway |
| BIOCARTA INTEGRIN PATHWAY | 38 | 29 | All SZGR 2.0 genes in this pathway |
| SA B细胞受体复合物 | 24 | 20 | All SZGR 2.0 genes in this pathway |
| SIG PIP3 SIGNALING IN B LYMPHOCYTES | 36 | 31 | All SZGR 2.0 genes in this pathway |
| SIG BCR SIGNALING PATHWAY | 46 | 38 | All SZGR 2.0 genes in this pathway |
| ST B CELL ANTIGEN RECEPTOR | 40 | 32 | All SZGR 2.0 genes in this pathway |
| PID RHOA REG PATHWAY | 46 | 30 | All SZGR 2.0 genes in this pathway |
| PID RAC1 REG PATHWAY | 38 | 25 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY RHO GTPASES | 113 | 81 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY FGFR IN DISEASE | 127 | 88 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY FGFR1 MUTANTS | 30 | 20 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | 19 | 12 | All SZGR 2.0 genes in this pathway |
| FGFR突变体的Reactome信号传导 | 44 | 29 | All SZGR 2.0 genes in this pathway |
| 中村肿瘤区周围与中央DN | 634 | 384 | All SZGR 2.0 genes in this pathway |
| HOLLMANN APOPTOSIS VIA CD40 DN | 267 | 178 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN | 116 | 79 | All SZGR 2.0 genes in this pathway |
| LIU CMYB TARGETS UP | 165 | 106 | All SZGR 2.0 genes in this pathway |
| 刘vmyb的目标 | 127 | 78 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP | 450 | 256 | All SZGR 2.0 genes in this pathway |
| Mullighan MLL签名1 DN | 242 | 165 | All SZGR 2.0 genes in this pathway |
| Mullighan MLL签名2 DN | 281 | 186 | All SZGR 2.0 genes in this pathway |
| 甲状腺癌的Rodrigues分化不佳的DN | 805 | 505 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP | 211 | 136 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| BARRIER CANCER RELAPSE NORMAL SAMPLE DN | 31 | 19 | All SZGR 2.0 genes in this pathway |
| myllykangas放大热点22 | 13 | 9 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC | 108 | 74 | All SZGR 2.0 genes in this pathway |
| 里克曼转移DN | 261 | 155 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| FAELT B CLL WITH VH3 21 UP | 44 | 30 | All SZGR 2.0 genes in this pathway |
| Krige对Tosedostat 6小时DN的响应 | 911 | 527 | All SZGR 2.0 genes in this pathway |
| Krige对Tosedostat 24小时DN的反应 | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS DN | 543 | 317 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
| Martinez RB1和TP53靶向DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
| Rizki肿瘤侵入性3D | 210 | 124 | All SZGR 2.0 genes in this pathway |
| 格雷希克癌症复制号码 | 323 | 240 | All SZGR 2.0 genes in this pathway |
| Nutt GBM与AO Glioma DN | 45 | 22 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER DN | 238 | 145 | All SZGR 2.0 genes in this pathway |
| Zhan变量早期分化基因上升 | 15 | 9 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH T 8 21 TRANSLOCATION | 368 | 247 | All SZGR 2.0 genes in this pathway |
| CHYLA CBFA2T3靶向 | 387 | 225 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| 棕熊UVC响应迟到 | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| Linsley mir16目标 | 206 | 127 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| ewsr1 fli1融合DN的TORCHIA目标 | 321 | 200 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |
| 霍尔曼天冬酰胺酶抗性B | 26 | 15 | All SZGR 2.0 genes in this pathway |
| 霍尔曼天冬酰胺酶抗性全部 | 22 | 14 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
| miRNA family | Target position | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| miR-145 | 2008 | 2015 | 1A，M8 | HSA-MIR-145 | GUCCAGUUUUCCCAGGAAUCCCUU |
| miR-15/16/195/424/497 | 419 | 425 | M8 | HSA-MIR-15Abrain | UAGCAGCACAUAAUGGUUUGUG |
| hsa-miR-16brain | UAGCAGCACGUAAAUAUUGGCG | ||||
| HSA-MIR-15Bbrain | UAGCAGCACAUCAUGGUUUACA | ||||
| HSA-MIR-195SZ | uagcagaaaaauauuggc | ||||
| hsa-miR-424 | CAGCAGCAAUUCAUGUUUUGAA | ||||
| HSA-MIR-497 | CAGCAGCACACUGUGGUUUGU | ||||
| miR-181 | 1059 | 1065 | 1A | hsa-miR-181abrain | AACAUUCAACGCUGUCGGUGAGU |
| hsa-miR-181bSZ | AACAUUCAUUGCUGUCGGUGGG | ||||
| hsa-miR-181cbrain | AACAUUCAACCUGUCGGUGAGU | ||||
| hsa-miR-181dbrain | AACAUUCAUUGUUGUCGGUGGGUU | ||||
| miR-26 | 983 | 990 | 1A，M8 | HSA-MIR-26Abrain | UUCAAGUAAUCCAGGAUAGGC |
| HSA-MIR-26BSZ | UUCAAGUAAUUCAGGAUAGGUU | ||||
| miR-96 | 2034 | 2040 | M8 | hsa-miR-96brain | uuuggcacuagcacauuuuugc |