Gene Page:RPS5

Summary?
GeneID 6193
Symbol RPS5
Synonyms S5
Description ribosomal protein S5
Reference MIM:603630|HGNC:HGNC:10426|Ensembl:ENSG00000083845|HPRD: 04695|Vega:OTTHUMG00000183530
Gene type protein-coding
Map location 19q13.4
Pascal p-value 0.014
Sherlock p-value 0.864
Fetal beta 0.955
DMG 1 (# studies)
eGene Anterior cingulate cortex BA24
Cerebellar Hemisphere
Myers' cis & trans
元
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06830426 19 58898769 RPS5 2.72E-9 -0.019 1.95E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs893179 chr19 58899055 RPS5 6193 0.05 cis
rs734379 chr19 58899181 RPS5 6193 0.01 cis
rs734379 19 58899182 RPS5 ENSG00000083845.4 2.394E-6 0.01 1415 gtex_brain_ba24
rs1529959 19 58899342 RPS5 ENSG00000083845.4 3.262 e-6 0.01 1575 gtex_brain_ba24
rs7250889 19 58900337 RPS5 ENSG00000083845.4 2.927E-6 0.01 2570 gtex_brain_ba24
rs7252333 19 58900747 RPS5 ENSG00000083845.4 2.929E-6 0.01 2980 gtex_brain_ba24
rs62116432 19 58901227 RPS5 ENSG00000083845.4 5.459E-6 0.01 3460 gtex_brain_ba24
rs7255491 19 58901394 RPS5 ENSG00000083845.4 2.952E-6 0.01 3627 gtex_brain_ba24
rs12460553 19 58903304 RPS5 ENSG00000083845.4 4.262E-6 0.01 5537 gtex_brain_ba24
rs8109932 19 58903466 RPS5 ENSG00000083845.4 2.988E-6 0.01 5699 gtex_brain_ba24
rs12460623 19 58903574 RPS5 ENSG00000083845.4 5.363E-6 0.01 5807 gtex_brain_ba24
rs8110182 19 58903699 RPS5 ENSG00000083845.4 7.057E-6 0.01 5932 gtex_brain_ba24
rs559225555 19 58905089 RPS5 ENSG00000083845.4 3.002E-6 0.01 7322 gtex_brain_ba24
rs2241787 19 58906163 RPS5 ENSG00000083845.4 3.023E-6 0.01 8396 gtex_brain_ba24
rs1010036 19 58907095 RPS5 ENSG00000083845.4 1.495E-6 0.01 9328 gtex_brain_ba24
rs12611212 19 58907443 RPS5 ENSG00000083845.4 4.972E-6 0.01 9676 gtex_brain_ba24
rs58682276 19 58909746 RPS5 ENSG00000083845.4 2.078E-6 0.01 11979 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26所示postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG RIBOSOME 88 43 All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION 222 75 All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX 74 24 All SZGR 2.0 genes in this pathway
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 179 53 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 84 30 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE CHAIN ELONGATION 153 41 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518 242 All SZGR 2.0 genes in this pathway
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 176 51 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE 203 72 All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 169 47 All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 176 57 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN 45 29 All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178 108 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 3 28 16 All SZGR 2.0 genes in this pathway
LUI TARGETS OF PAX8 PPARG FUSION 34 23 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE DN 32 22 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION UP 86 55 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRACX UP 20 14 All SZGR 2.0 genes in this pathway
WHITESIDE CISPLATIN RESISTANCE DN 13 9 All SZGR 2.0 genes in this pathway
ABE INNER EAR 48 26 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN 175 103 All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM UP 47 30 All SZGR 2.0 genes in this pathway
FLOTHO PEDIATRIC ALL THERAPY RESPONSE UP 53 33 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 115 74 All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP 143 100 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335 193 All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 VIA ERCC6 DN 46 31 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
LI DCP2 BOUND MRNA 89 57 All SZGR 2.0 genes in this pathway
BILANGES SERUM AND RAPAMYCIN SENSITIVE GENES 68 35 All SZGR 2.0 genes in this pathway
BILANGES SERUM RESPONSE TRANSLATION 37 20 All SZGR 2.0 genes in this pathway
HOLLEMAN ASPARAGINASE RESISTANCE B ALL UP 26 15 All SZGR 2.0 genes in this pathway