SZGR2 - Beplay体育中心

Summary？

基因	6196
象征	RPS6KA2
Synonyms	Hu-2 \| mapkapk1c \| rsk \| rsk3 \| s6k-alpha \| s6k-alpha2 \| p90-rsk3 \| p90rsk2 \| pp90rsk3
Description	核糖体蛋白S6激酶A2
Reference	MIM：601685\|HGNC:HGNC:10431\|ENSEMBL：ENSG00000071242\|HPRD：03403\|Vega：Otthumg0000000016007
基因类型	蛋白质编码
Map location	6q27
Pascal p-value	0.061
胎儿β	-0.629
DMG	1 (# studies)
主持人	Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:GWASdb	Genome-wide Association Studies	精神分裂症的GWASDB记录
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	4
Network	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.0033

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
CG12983741	6	167136259	RPS6KA2	1.55E-5	0.625	0.015	DMG：Wockner_2014
cg22610106	6	167136367	RPS6KA2	5.6E-5	0.609	0.022	DMG：Wockner_2014
CG03107179	6	167065376	RPS6KA2	1.519E-4	0.566	0.032	DMG：Wockner_2014
CG15321401	6	166884430	RPS6KA2	2.179E-4	0.331	0.036	DMG：Wockner_2014

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS4322086	Chr9	85787717	RPS6KA2	6196		0.19		反式
RS1551831	CHR15	70055300	RPS6KA2	6196		0.13		反式

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC:分皮质区域;SM:感觉运动区域s; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene	Pearson's Correlation	斯皮尔曼的相关性
RPL30	0.96	0.94
RPS8	0.96	0.94
RPL6P10	0.96	0.92
RPL23	0.96	0.95
RPL27A	0.95	0.94
RPL35A	0.95	0.92
RPS25P8	0.94	0.93
RPL38	0.93	0.91
RPS20	0.93	0.92
RPL11	0.93	0.91

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
ATP10A	-0.62	-0.81
FBXO2	-0.58	-0.68
HLA-F	-0.58	-0.69
ZNF385A	-0.57	-0.72
tinagl1	-0.57	-0.76
BCl2L2	-0.57	-0.78
LDHD	-0.57	-0.69
SLC6A12	-0.57	-0.77
ptprb	-0.56	-0.73
EDN3	-0.56	-0.71

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0000166	nucleotide binding	IEA		-
去：0000287	镁离子结合	IEA		-
去：0005524	ATP binding	IEA		-
去：0004674	protein serine/threonine kinase activity	经验		9770464
去：0004674	protein serine/threonine kinase activity	TAS		7623830
GO：0016740	转移酶活性	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
去：0006468	protein amino acid phosphorylation	IEA		-
GO:0007243	蛋白激酶级联反应	TAS		8141249
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005634	nucleus	TAS		7623830
去：0005654	核质	经验		9770464\|16626623

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg mapk信号通路	267	205	All SZGR 2.0 genes in this pathway
Kegg卵母细胞减数分裂	114	79	All SZGR 2.0 genes in this pathway
kegg mtor信号通路	52	40	All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION	70	57	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG孕酮介导的卵母细胞成熟	86	59	All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY	87	68	All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK途径	32	25	All SZGR 2.0 genes in this pathway
SIG PIP3在心脏肌周期中发出信号	67	54	All SZGR 2.0 genes in this pathway
心肌细胞中的SIG胰岛素受体途径	51	41	All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN B LYMPHOCYTES	36	31	All SZGR 2.0 genes in this pathway
ST磷酸肌醇3激酶途径	37	29	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
Reactome NGF信号通过TRKA从质膜发出	137	105	All SZGR 2.0 genes in this pathway
Reactome胃胃CREB信号传导途径通过PKC和MAPK	205	136	All SZGR 2.0 genes in this pathway
Reactome核事件激酶和转录因子激活	24	20	All SZGR 2.0 genes in this pathway
REACTOME ERK MAPK TARGETS	21	17	All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
反应组神经递质受体结合和突触后细胞中的下游传播	137	110	All SZGR 2.0 genes in this pathway
Reactome Axon指导	251	188	All SZGR 2.0 genes in this pathway
NMDA受体在谷氨酸结合和突触后事件上的反应组激活	37	32	All SZGR 2.0 genes in this pathway
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	27	23	All SZGR 2.0 genes in this pathway
反应组后NMDA受体激活事件	33	28	All SZGR 2.0 genes in this pathway
TLR级联反应组MAP激酶激活	50	37	All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	30	24	All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS	86	62	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1	34	25	All SZGR 2.0 genes in this pathway
REACTOME RECYCLING PATHWAY OF L1	27	15	All SZGR 2.0 genes in this pathway
Reactome Traf6在TLR7 8或9激活上介导的NFKB和MAP激酶的诱导	77	57	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
Reactome myd88 mal级联反应于质膜发起	83	63	All SZGR 2.0 genes in this pathway
Reactome先天免疫系统	279	178	All SZGR 2.0 genes in this pathway
Reactome激活的TLR4信号传导	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
Reactome收费受体级联	118	84	All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤	783	507	All SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血红斑dn	493	298	All SZGR 2.0 genes in this pathway
Chemnitz对前列腺素E2 DN的反应	391	222	All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP	165	106	All SZGR 2.0 genes in this pathway
刘vmyb的目标	127	78	All SZGR 2.0 genes in this pathway
NUP98 HOXA9融合8D DN的Takeda目标	205	127	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN	142	90	All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 16d DN的Takeda目标	143	83	All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP	95	64	All SZGR 2.0 genes in this pathway
Mullighan MLL签名2 DN	281	186	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
ENK UV响应表皮DN	508	354	All SZGR 2.0 genes in this pathway
甲状腺癌	443	294	All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS DN	14	14	All SZGR 2.0 genes in this pathway
Markey RB1慢性LOF DN	118	78	All SZGR 2.0 genes in this pathway
环氧素DN的浓凋亡	172	112	All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合目标G DN	35	18	All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
Benporath Myc Max目标	775	494	All SZGR 2.0 genes in this pathway
Onder CDH1目标2向上	256	159	All SZGR 2.0 genes in this pathway
马纳洛缺氧	207	145	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN	184	132	All SZGR 2.0 genes in this pathway
NPM1突变DN的Verhaak AML	246	180	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN	148	102	All SZGR 2.0 genes in this pathway
Browne HCMV感染18小时DN	178	121	All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN	220	147	All SZGR 2.0 genes in this pathway
海勒被甲基化DN沉默	105	67	All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默	461	298	All SZGR 2.0 genes in this pathway
riggi ewing肉瘤祖先DN	191	123	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP	439	257	All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存次优秀	510	309	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN	216	143	All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜	425	298	All SZGR 2.0 genes in this pathway
Shedden肺癌良好生存A4	196	124	All SZGR 2.0 genes in this pathway
Han Satb1靶向DN	442	275	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 9	35	26	All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA UP	75	43	All SZGR 2.0 genes in this pathway
fontaine乳头状甲状腺癌	66	38	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
由PML Rara Fusion绑定的Martens	456	287	All SZGR 2.0 genes in this pathway
lu eszh2靶向DN	414	237	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
EWSR1 ETS融合DN的Miyagawa目标	229	135	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-200bc/429	2912	2918	M8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
mir-218	2986	2992	M8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-26	2313	2319	M8	HSA-MIR-26A^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	2313	2319	M8	HSA-MIR-26B^SZ	UUCAAGUAAUUCAGGAUAGGUU
mir-30-5p	3243	3250	1A，M8	HSA-MIR-30A-5P	uguaaaacauccuccugagaag
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	uguaaacauccuaccucucagcu
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
mir-9	551	557	1a	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:RPS6KA2