Gene Page:RRBP1

概括?
基因 6238
Symbol RRBP1
Synonyms ES/130|ES130|RRp|hES
Description 核糖体binding protein 1
Reference MIM：601418|HGNC:HGNC:10448|Ensembl:ENSG00000125844|HPRD:11796|Vega:OTTHUMG00000031945
Gene type protein-coding
Map location 20p12
Pascal p-value 0.007
eGene Myers' cis & trans
Support RNA AND PROTEIN SYNTHESIS
Ascano FMRP targets

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.046
Expression Meta-analysis of gene expression Pvalue: 1.672

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16958358 chr17 55502410 RRBP1 6238 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C16orf89 0.84 0.86
PTGDS 0.84 0.90
CSRP1 0.82 0.92
S100B 0.82 0.90
ROM1 0.82 0.89
ALDH1A1 0.81 0.90
FXYD1 0.80 0.90
SLC25A18 0.80 0.89
NDRG2 0.80 0.91
PAMR1 0.79 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BLMH -0.72 -0.84
PNMA1 -0.71 -0.78
PSPC1 -0.70 -0.84
ARMCX5 -0.70 -0.83
PJA1 -0.70 -0.84
PURG -0.70 -0.79
XPNPEP1 -0.69 -0.81
TOPBP1 -0.69 -0.81
COPG2 -0.69 -0.83
HEATR5B -0.68 -0.80

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity TAS 9628588
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006412 translation TAS 9628588
GO:0007165 signal transduction NAS -
GO:0015031 protein transport IEA -
GO:0065002 intracellular protein transmembrane transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005840 核糖体 TAS 9628588
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005783 endoplasmic reticulum NAS 9628588
去：0016020 membrane IEA -
GO：0016021 integral to membrane IEA -
GO:0030176 integral to endoplasmic reticulum membrane NAS -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
HOLLMANN APOPTOSIS VIA CD40 DN 267 178 该途径中的所有SZGR 2.0基因
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 该途径中的所有SZGR 2.0基因
DAVICIONI MOLECULAR ARMS VS ERMS DN 182 111 该途径中的所有SZGR 2.0基因
Huttmann B Cll生存不佳 276 187 该途径中的所有SZGR 2.0基因
DOANE RESPONSE TO ANDROGEN UP 184 125 该途径中的所有SZGR 2.0基因
RODRIGUES NTN1 TARGETS DN 158 102 该途径中的所有SZGR 2.0基因
BILBAN B CLL LPL UP 63 39 该途径中的所有SZGR 2.0基因
MULLIGHAN MLL SIGNATURE 1 UP 380 236 该途径中的所有SZGR 2.0基因
MULLIGHAN MLL SIGNATURE 2 UP 418 263 该途径中的所有SZGR 2.0基因
LEE NEURAL CREST STEM CELL UP 146 99 该途径中的所有SZGR 2.0基因
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE KERATINOCYTE DN 485 334 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 该途径中的所有SZGR 2.0基因
MISSIAGLIA REGULATED BY METHYLATION UP 126 78 该途径中的所有SZGR 2.0基因
TERAMOTO OPN TARGETS CLUSTER 7 19 16 该途径中的所有SZGR 2.0基因
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229 137 该途径中的所有SZGR 2.0基因
NUYTTEN EZH2 TARGETS UP 1037 673 该途径中的所有SZGR 2.0基因
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283 177 该途径中的所有SZGR 2.0基因
AMIT EGF RESPONSE 480 HELA 164 118 该途径中的所有SZGR 2.0基因
SHEN SMARCA2 TARGETS DN 357 212 该途径中的所有SZGR 2.0基因
MORI PLASMA CELL UP 51 29 该途径中的所有SZGR 2.0基因
PENG GLUCOSE DEPRIVATION DN 169 112 该途径中的所有SZGR 2.0基因
ALCALAY AML BY NPM1 LOCALIZATION UP 140 83 该途径中的所有SZGR 2.0基因
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 该途径中的所有SZGR 2.0基因
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 该途径中的所有SZGR 2.0基因
YAMAZAKI TCEB3 TARGETS UP 175 116 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE UP 1691年 1088 该途径中的所有SZGR 2.0基因
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 该途径中的所有SZGR 2.0基因
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 该途径中的所有SZGR 2.0基因
Heller HDAC靶向被甲基化的沉默 461 298 该途径中的所有SZGR 2.0基因
SWEET LUNG CANCER KRAS UP 491 316 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 该途径中的所有SZGR 2.0基因
BOYAULT肝癌子类G6 DN 19 13 该途径中的所有SZGR 2.0基因
YAGI AML WITH 11Q23 REARRANGED 351 238 该途径中的所有SZGR 2.0基因
WONG ADULT TISSUE STEM MODULE 721 492 该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10 69 38 该途径中的所有SZGR 2.0基因
FEVR CTNNB1 TARGETS UP 682 433 该途径中的所有SZGR 2.0基因
IKEDA MIR1 TARGETS UP 53 39 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 52 58 m8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-124.1 44 50 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 44 50 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
mir-135 122 128 m8 hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b Uauggcuuuucauuccuaugug
miR-25/32/92/363/367 321 327 m8 hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 Aauugcacuuuagcaaugga
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-299-5p 66 72 1A hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-382 31 37 1A hsa-miR-382brain GAAGUUGUUCGUGGUGGAUUCG
mir-542-3p 194 200 1A hsa-miR-542-3p UGUGACAGAUUGAUAACUGAAA