Gene Page:RREB1

Summary?
GeneID 6239
Symbol RREB1
Synonyms FINB|HNT|LZ321|RREB-1|Zep-1
Description ras responsive element binding protein 1
Reference MIM:602209|HGNC:HGNC:10449|Ensembl:ENSG00000124782|HPRD:03733|Vega:OTTHUMG00000014201
Gene type protein-coding
Map location 6p25
Pascal p-value 0.035
Sherlock p-value 2.787E-4
Fetal beta -0.449
DMG 2 (# studies)
eGene 元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 3
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
GSMA_I Genome scan meta-analysis Psr: 0.0159

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg08355568 6 7108248 RREB1 2.968E-4 -0.387 0.039 DMG:Wockner_2014
cg08651674 6 7108441 RREB1 -0.035 0.35 DMG:Nishioka_2013
cg18533466 6 7107952 RREB1 -0.02 0.94 DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RAPGEF5 0.93 0.86
LANCL1 0.90 0.89
PRUNE2 0.90 0.82
ENPP4 0.89 0.87
ENDOD1 0.89 0.82
FAM73A 0.89 0.87
ARFGEF2 0.89 0.88
MFSD6 0.89 0.88
CLIP4 0.89 0.82
PCDH9 0.88 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BCL7C -0.47 -0.52
AC006276.2 -0.47 -0.48
RPL35 -0.44 -0.50
RPL36 -0.43 -0.48
TBC1D10A -0.43 -0.35
ST20 -0.42 -0.49
RPL12 -0.42 -0.42
RPLP1 -0.41 -0.42
C9orf46 -0.41 -0.41
RPL31 -0.40 -0.46

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding IEA -
GO:0008270 zinc ion binding IEA -
GO:0016563 transcription activator activity TAS 9305772
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
去:0006355 regulation of transcription, DNA-dependent TAS 9305772
去:0006350 transcription IEA -
GO:0006366 transcription from RNA polymerase II promoter TAS 8816445
GO:0007265 Ras protein signal transduction TAS 8816445
GO:0007275 multicellular organismal development TAS 8816445
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005634 nucleus TAS 9305772
GO:0005737 cytoplasm TAS 9305772
GO:0016607 nuclear speck IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
HOOI ST7 TARGETS DN 123 78 所有SZGR 2.0genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244 147 所有SZGR 2.0genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 所有SZGR 2.0genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 所有SZGR 2.0genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170 114 所有SZGR 2.0genes in this pathway
MIDORIKAWA AMPLIFIED IN LIVER CANCER 55 38 所有SZGR 2.0genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 所有SZGR 2.0genes in this pathway
THEODOROU MAMMARY TUMORIGENESIS 31 24 所有SZGR 2.0genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 所有SZGR 2.0genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 所有SZGR 2.0genes in this pathway
KOYAMA SEMA3B TARGETS UP 292 168 所有SZGR 2.0genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN 85 67 所有SZGR 2.0genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 所有SZGR 2.0genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 所有SZGR 2.0genes in this pathway
BURTON ADIPOGENESIS 5 126 78 所有SZGR 2.0genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 所有SZGR 2.0genes in this pathway
TAYLOR METHYLATED IN ACUTE LYMPHOBLASTIC LEUKEMIA 77 52 所有SZGR 2.0genes in this pathway
YOSHIOKA LIVER CANCER EARLY RECURRENCE DN 65 31 所有SZGR 2.0genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7 76 46 所有SZGR 2.0genes in this pathway
KIM ALL DISORDERS CALB1 CORR DN 37 20 所有SZGR 2.0genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 所有SZGR 2.0genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 所有SZGR 2.0genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 所有SZGR 2.0genes in this pathway
DELACROIX RAR BOUND ES 462 273 所有SZGR 2.0genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 所有SZGR 2.0genes in this pathway
LIM MAMMARY STEM CELL DN 428 246 所有SZGR 2.0genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 所有SZGR 2.0genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 995 1001 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-124.1 218 225 1A,m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 217 224 1A,m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-144 995 1001 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-145 457 464 1A,m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-155 335 341 m8 hsa-miR-155 UUAAUGCUAAUCGUGAUAGGGG
miR-23 472 478 1A hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC