Gene Page:RYR3

Summary?
GeneID 6263
Symbol RYR3
Synonyms RYR-3
Description ryanodine receptor 3
Reference MIM:180903|HGNC:HGNC:10485|Ensembl:ENSG00000198838|HPRD:01620|Vega:OTTHUMG00000172253
Gene type protein-coding
Map location 15q13.3
Pascal p-value 0.015
Sherlock p-value 0.69
TADA p-value 0.007
Fetal beta -0.426
Support INTRACELLULAR SIGNAL TRANSDUCTION
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccur High-throughput literature-search 系统搜索PubMed的共病的基因with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
RYR3 chr15 33999249 G A NM_001036
NM_001243996		 p.2205V>M
p.2205V>M		 missense
missense		 Schizophrenia DNM:Fromer_2014
RYR3 chr15 34151822 T C NM_001036
NM_001243996		 p.4730I>T
p.4725I>T		 missense
missense		 Schizophrenia DNM:Fromer_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DDR1 0.90 0.90
HEATR2 0.87 0.87
LIX1L 0.87 0.91
FHL1 0.86 0.86
GOLM1 0.86 0.86
DAG1 0.86 0.86
AC130686.2 0.85 0.84
SEPN1 0.85 0.89
FYN 0.85 0.88
FAM57A 0.85 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.65 -0.71
AF347015.31 -0.63 -0.75
MT-CO2 -0.63 -0.75
AF347015.27 -0.61 -0.73
CA4 -0.61 -0.68
AF347015.33 -0.60 -0.71
MYL3 -0.60 -0.72
FXYD1 -0.59 -0.70
AF347015.21 -0.59 -0.78
COX4I2 -0.59 -0.69

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169 110 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP 94 59 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390 236 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
ROSS AML OF FAB M7 TYPE 68 44 All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191 131 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway