SZGR2 - Beplay体育中心

Summary?

GeneID	6279
Symbol	S100A8
Synonyms	60B8AG\|CAGA\|CFAG\|CGLA\|CP-10\|L1Ag\|MA387\|MIF\|MRP8\|NIF\|P8
Description	S100 calcium binding protein A8
Reference	MIM:123885\|HGNC:HGNC:10498\|Ensembl:ENSG00000143546\|HPRD:00471\|Vega:OTTHUMG00000013124
Gene type	protein-coding
Map location	1q21
Sherlock p-value	0.885
Fetal beta	-2.241
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.0235
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.00814
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs16982680	chr2	16885880	S100A8	6279	0.13	trans
rs1882577	chr2	227574206	S100A8	6279	0.01	trans
rs6762670	chr3	140756258	S100A8	6279	0.15	trans
rs11915229	chr3	140758709	S100A8	6279	0.1	trans
rs2916688	chr8	6221560	S100A8	6279	0.04	trans
rs12547480	chr8	13397698	S100A8	6279	0.16	trans
rs17111522	chr14	41634403	S100A8	6279	0.19	trans
rs11850244	chr14	82523917	S100A8	6279	0.1	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005509	calcium ion binding	TAS		2149559
GO:0005515	protein binding	新闻学会		17353931
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006954	inflammatory response	TAS		3313057

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ASB3	ASB-3 \| FLJ10123 \| FLJ10421 \| MGC12531 \| MGC132002 \| MGC996	ankyrin repeat and SOCS box-containing 3	Affinity Capture-MS	BioGRID	17353931
C14orf1	ERG28 \| NET51	chromosome 14 open reading frame 1	Two-hybrid	BioGRID	16169070
C1orf103	FLJ11269 \| RIF1 \| RP11-96K19.1	chromosome 1 open reading frame 103	Two-hybrid	BioGRID	16169070
CEACAM3	CD66D \| CEA \| CGM1 \| MGC119875 \| W264 \| W282	carcinoembryonic antigen-related cell adhesion molecule 3	-	HPRD	11708798
CHGB	SCG1	chromogranin B (secretogranin 1)	Two-hybrid	BioGRID	16169070
GDF9	-	growth differentiation factor 9	Two-hybrid	BioGRID	16169070
IGSF21	FLJ41177 \| MGC15730	immunoglobin superfamily, member 21	Two-hybrid	BioGRID	16169070
LRRK1	FLJ23119 \| FLJ27465 \| KIAA1790 \| RIPK6 \| Roco1	leucine-rich repeat kinase 1	Affinity Capture-MS	BioGRID	17353931
MOBKL1B	C2orf6 \| FLJ10788 \| FLJ11595 \| MATS1 \| MOB1 \| MOBK1B \| Mob4B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	Affinity Capture-MS	BioGRID	17353931
NUAK1	ARK5 \| KIAA0537	NUAK family, SNF1-like kinase, 1	Affinity Capture-MS	BioGRID	17353931
PDCD11	ALG-4 \| ALG4 \| KIAA0185 \| NFBP	programmed cell death 11	Two-hybrid	BioGRID	16169070
PPIA	CYPA \| CYPH \| MGC117158 \| MGC12404 \| MGC23397	peptidylprolyl isomerase A (cyclophilin A)	Two-hybrid	BioGRID	16169070
PPM1B	MGC21657 \| PP2C-beta-X \| PP2CB \| PP2CBETA \| PPC2BETAX	protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform	Affinity Capture-MS	BioGRID	17353931
PRMT1	ANM1 \| HCP1 \| HRMT1L2 \| IR1B4	protein arginine methyltransferase 1	Two-hybrid	BioGRID	16169070
S100A8	60B8AG \| CAGA \| CFAG \| CGLA \| CP-10 \| L1Ag \| MA387 \| MIF \| MRP8 \| NIF \| P8	S100 calcium binding protein A8	-	HPRD,BioGRID	10771424
S100A9	60B8AG \| CAGB \| CFAG \| CGLB \| L1AG \| LIAG \| MAC387 \| MIF \| MRP14 \| NIF \| P14	S100 calcium binding protein A9	-	HPRD	11867565
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Two-hybrid	BioGRID	16169070
UNC119	HRG4	unc-119 homolog (C. elegans)	Two-hybrid	BioGRID	16169070
USF2	FIP \| bHLHb12	upstream transcription factor 2, c-fos interacting	Affinity Capture-MS	BioGRID	17353931

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID TOLL ENDOGENOUS PATHWAY	25	19	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN	175	82	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN	116	79	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP	450	256	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL UP	121	45	All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 DN	48	28	All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN	244	153	All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN	258	141	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D DN	31	19	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN	205	127	All SZGR 2.0 genes in this pathway
PEPPER CHRONIC LYMPHOCYTIC LEUKEMIA UP	33	28	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP	78	41	All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA UP	141	75	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN	226	132	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP	293	179	All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN	25	13	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK UP	116	68	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN	79	54	All SZGR 2.0 genes in this pathway
DUNNE TARGETS OF AML1 MTG8 FUSION UP	52	32	All SZGR 2.0 genes in this pathway
HUMMERICH BENIGN SKIN TUMOR UP	18	8	All SZGR 2.0 genes in this pathway
HUMMERICH MALIGNANT SKIN TUMOR UP	16	8	All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP	142	96	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP	162	104	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP	147	101	All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP	146	104	All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS UP	28	14	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 6	84	54	All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL	116	62	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL	326	213	All SZGR 2.0 genes in this pathway
AIYAR COBRA1 TARGETS UP	39	25	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN	156	106	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN	382	224	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 6	11	9	All SZGR 2.0 genes in this pathway
不知道是携带者TARGETS 2 DN	464	276	All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS UP	50	30	All SZGR 2.0 genes in this pathway
ROSS AML WITH CBFB MYH11 FUSION	52	32	All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP	71	51	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP	87	58	All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO HD MTX UP	23	13	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN	128	90	All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS	126	90	All SZGR 2.0 genes in this pathway
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS	31	21	All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR DN	63	41	All SZGR 2.0 genes in this pathway
SCHLINGEMANN SKIN CARCINOGENESIS TPA UP	42	24	All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART DN	42	32	All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY UP	45	29	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN	371	218	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 24HR	43	30	All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN	245	144	All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP	253	147	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6	189	112	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN	220	147	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN	154	101	All SZGR 2.0 genes in this pathway
YAMASHITA METHYLATED IN PROSTATE CANCER	57	29	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN	315	197	All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN	564	326	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP	147	83	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING UP	56	36	All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL UP	54	29	All SZGR 2.0 genes in this pathway
DAVIES MULTIPLE MYELOMA VS MGUS DN	28	18	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN	252	155	All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP	131	79	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP	101	66	All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN	222	141	All SZGR 2.0 genes in this pathway
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN	9	7	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP	221	135	All SZGR 2.0 genes in this pathway
KAMIKUBO MYELOID CEBPA NETWORK	28	19	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP	857	456	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN	88	59	All SZGR 2.0 genes in this pathway
金所有障碍CALB1 CORR DN	37	20	All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN	242	146	All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP	121	70	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF	367	231	All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES	275	155	All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL PROGENITOR UP	58	30	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS	344	197	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Gene Page:S100A8