Gene Page:S100A9

Summary?
GeneID 6280
Symbol S100A9
同义词 60B8AG|CAGB|CFAG|CGLB|L1AG|LIAG|MAC387|MIF|MRP14|NIF|P14
Description S100 calcium binding protein A9
Reference MIM:123886|HGNC:HGNC:10499|Ensembl:ENSG00000163220|HPRD:00472|Vega:OTTHUMG00000013125
Gene type protein-coding
Map location 1q21
Sherlock p-value 0.587
Fetal beta -0.229
eGene Myers' cis & trans
Support G2Cdb.human_clathrin
G2Cdb.human_Synaptosome
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统atic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0235
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00814
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16982680 chr2 16885880 S100A9 6280 9.225E-4 trans
rs1524554 chr2 16903891 S100A9 6280 0.02 trans
rs17044829 chr2 23351210 S100A9 6280 0.13 trans
rs1882577 chr2 227574206 S100A9 6280 0.04 trans
rs17721983 chr3 71855935 S100A9 6280 0.1 trans
rs17181054 chr4 24000756 S100A9 6280 0.09 trans
rs12190591 chr6 99593257 S100A9 6280 0.04 trans
rs17541846 chr7 122789378 S100A9 6280 0.01 trans
rs6997614 chr8 6217185 S100A9 6280 0.06 trans
rs2916688 chr8 6221560 S100A9 6280 0.01 trans
snp_a-4233588 0 S100A9 6280 0.04 trans
rs16971150 chr15 79898662 S100A9 6280 0.15 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TSC1 0.92 0.94
ZSCAN29 0.92 0.93
GPATCH8 0.92 0.92
DIP2A 0.91 0.92
ZZEF1 0.91 0.93
ZNF318 0.91 0.92
GON4L 0.91 0.92
ZFYVE26 0.91 0.92
EP400 0.91 0.93
TNRC6A 0.91 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.67 -0.73
HIGD1B -0.66 -0.76
IFI27 -0.66 -0.72
MT-CO2 -0.66 -0.72
AF347015.21 -0.66 -0.78
FXYD1 -0.64 -0.70
C1orf54 -0.63 -0.81
VAMP5 -0.63 -0.74
S100A16 -0.63 -0.70
CXCL14 -0.62 -0.68

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004871 signal transducer activity TAS 3313057
GO:0005509 calcium ion binding TAS 2149559
GO:0005515 protein binding 新闻学会 17353931|17620599
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007267 cell-cell signaling TAS 3313057
GO:0006954 inflammatory response TAS 3313057
GO:0030595 leukocyte chemotaxis IEA -
GO:0031532 actin cytoskeleton reorganization IEA -
GO:0045113 regulation of integrin biosynthetic process IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 18029348
GO:0005730 nucleolus IDA 18029348
GO:0005737 cytoplasm IDA 18029348

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID TOLL ENDOGENOUS PATHWAY 25 19 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA DN 349 157 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 175 82 All SZGR 2.0 genes in this pathway
图姆收缩期心力衰竭 423 283 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 116 79 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244 153 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258 141 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D DN 31 19 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205 127 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187 115 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
HUMMERICH BENIGN SKIN TUMOR UP 18 8 All SZGR 2.0 genes in this pathway
HUMMERICH MALIGNANT SKIN TUMOR UP 16 8 All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 142 96 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162 104 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147 101 All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146 104 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 6 84 54 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
MURATA VIRULENCE OF H PILORI 24 16 All SZGR 2.0 genes in this pathway
WIEMANN TELOMERE SHORTENING AND CHRONIC LIVER DAMAGE DN 6 5 All SZGR 2.0 genes in this pathway
HOWLIN PUBERTAL MAMMARY GLAND 69 40 All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION 147 80 All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 9 19 13 All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN 76 52 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
ROSS AML WITH CBFB MYH11 FUSION 52 32 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO HD MTX UP 23 13 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE UP 60 42 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA UP 60 40 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 128 90 All SZGR 2.0 genes in this pathway
TAVOR CEBPA TARGETS UP 48 36 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA DN 41 27 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G3 15 10 All SZGR 2.0 genes in this pathway
SCHLINGEMANN SKIN CARCINOGENESIS TPA UP 42 24 All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 6M 74 47 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 3M 59 36 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245 144 All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN 106 68 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE DN 51 28 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253 147 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN PLEURA DN 27 15 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 147 83 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING UP 56 36 All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL UP 54 29 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252 155 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 131 79 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315 201 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235 144 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP 101 66 All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222 141 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G24 28 19 All SZGR 2.0 genes in this pathway
KAMIKUBO MYELOID CEBPA NETWORK 28 19 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242 146 All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP 121 70 All SZGR 2.0 genes in this pathway
AZARE STAT3 TARGETS 24 12 All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway