基因页:MAPK12
Summary?
基因 | 6300 |
象征 | MAPK12 |
同义词 | erk-6 | erk3 | erk6 | mapk 12 | p38gamma | prkm12 | sapk-3 | sapk3 |
Description | 有丝分裂原激活的蛋白激酶12 |
Reference | MIM:602399|HGNC:HGNC:6874|Ensembl:ENSG00000188130|HPRD:03868|Vega:Otthumg00000030145 |
基因类型 | 蛋白质编码 |
地图位置 | 22q13.33 |
Pascal P值 | 0.014 |
胎儿β | -0.321 |
DMG | 1(# studies) |
主持人 | 前扣带回皮层BA24 尾状基底神经节 小脑半球 小脑 皮质 Frontal Cortex BA9 海马 Hypothalamus 伏隔核基底神经节 Putamen basal ganglia 元 |
基因in Data Sources
基因集名称 | 基因组方法 | Description | 信息 |
---|---|---|---|
简历:PGCNP | 全基因组协会研究 | GWAS | |
DMG:Nishioka_2013 | 全基因组DNA甲基化分析 | 作者研究了来自18例第一期精神分裂症(FESZ)和15个正常对照的18例外周血细胞中DNA的甲基化谱。 | 1 |
Section I. Genetics and epigenetics annotation
差异甲基化基因
探测 | 染色体 | 位置 | 最近的基因 | p(dis) | Beta (dis) | fdr(dis) | 学习 |
---|---|---|---|---|---|---|---|
CG15134628 | 22 | 50699649 | MAPK12 | -0.023 | 0.27 | DMG:Nishioka_2013 |
EQTL注释
SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | PVALUE | QVALUE | TSS距离 | EQTL类型 |
---|---|---|---|---|---|---|---|---|
RS199505423 | 22 | 50670801 | MAPK12 | ENSG00000188130.9 | 1.674E-6 | 0 | 29453 | gtex_brain_ba24 |
rs13055135 | 22 | 50672479 | MAPK12 | ENSG00000188130.9 | 3.453E-7 | 0 | 27775 | gtex_brain_ba24 |
rs67157296 | 22 | 50672877 | MAPK12 | ENSG00000188130.9 | 6.05e-7 | 0 | 27377 | gtex_brain_ba24 |
RS67881086 | 22 | 50673439 | MAPK12 | ENSG00000188130.9 | 3.334e-7 | 0 | 26815 | gtex_brain_ba24 |
rs5771256 | 22 | 50674232 | MAPK12 | ENSG00000188130.9 | 1.004E-6 | 0 | 26022 | gtex_brain_ba24 |
rs5771258 | 22 | 50675648 | MAPK12 | ENSG00000188130.9 | 9.913E-7 | 0 | 24606 | gtex_brain_ba24 |
RS9628271 | 22 | 50676459 | MAPK12 | ENSG00000188130.9 | 4.893E-7 | 0 | 23795 | gtex_brain_ba24 |
RS6010213 | 22 | 50676839 | MAPK12 | ENSG00000188130.9 | 5.548e-7 | 0 | 23415 | gtex_brain_ba24 |
RS200713867 | 22 | 50676973 | MAPK12 | ENSG00000188130.9 | 1.826E-6 | 0 | 23281 | gtex_brain_ba24 |
RS6010216 | 22 | 50679471 | MAPK12 | ENSG00000188130.9 | 5.97E-8 | 0 | 20783 | gtex_brain_ba24 |
RS7290465 | 22 | 50679758 | MAPK12 | ENSG00000188130.9 | 3.087E-8 | 0 | 20496 | gtex_brain_ba24 |
rs200968480 | 22 | 50682063 | MAPK12 | ENSG00000188130.9 | 3.68e-8 | 0 | 18191 | gtex_brain_ba24 |
RS7292864 | 22 | 50683792 | MAPK12 | ENSG00000188130.9 | 6.335E-8 | 0 | 16462 | gtex_brain_ba24 |
RS13058062 | 22 | 50684296 | MAPK12 | ENSG00000188130.9 | 5.796E-8 | 0 | 15958 | gtex_brain_ba24 |
RS738334 | 22 | 50688235 | MAPK12 | ENSG00000188130.9 | 6.152E-13 | 0 | 12019 | gtex_brain_ba24 |
RS1555048 | 22 | 50688348 | MAPK12 | ENSG00000188130.9 | 5.7E-13 | 0 | 11906 | gtex_brain_ba24 |
RS909688 | 22 | 50689030 | MAPK12 | ENSG00000188130.9 | 1.948e-13 | 0 | 11224 | gtex_brain_ba24 |
RS2341111 | 22 | 50690322 | MAPK12 | ENSG00000188130.9 | 1.675E-13 | 0 | 9932 | gtex_brain_ba24 |
rs5771276 | 22 | 50692562 | MAPK12 | ENSG00000188130.9 | 2.964e-12 | 0 | 7692 | gtex_brain_ba24 |
RS2009816 | 22 | 50692848 | MAPK12 | ENSG00000188130.9 | 1.037E-12 | 0 | 7406 | gtex_brain_ba24 |
RS2880034 | 22 | 50692853 | MAPK12 | ENSG00000188130.9 | 1.876E-8 | 0 | 7401 | gtex_brain_ba24 |
RS2009815 | 22 | 50692856 | MAPK12 | ENSG00000188130.9 | 7.845e-10 | 0 | 7398 | gtex_brain_ba24 |
RS4077315 | 22 | 50692908 | MAPK12 | ENSG00000188130.9 | 3.959E-9 | 0 | 7346 | gtex_brain_ba24 |
RS2002766 | 22 | 50692966 | MAPK12 | ENSG00000188130.9 | 1.648e-11 | 0 | 7288 | gtex_brain_ba24 |
rs5771280 | 22 | 50693340 | MAPK12 | ENSG00000188130.9 | 5.21e-14 | 0 | 6914 | gtex_brain_ba24 |
rs5771281 | 22 | 50693479 | MAPK12 | ENSG00000188130.9 | 5.206E-14 | 0 | 6775 | gtex_brain_ba24 |
rs5771282 | 22 | 50693521 | MAPK12 | ENSG00000188130.9 | 4.042E-12 | 0 | 6733 | gtex_brain_ba24 |
RS6010218 | 22 | 50693534 | MAPK12 | ENSG00000188130.9 | 8.961e-12 | 0 | 6720 | gtex_brain_ba24 |
RS6010219 | 22 | 50693538 | MAPK12 | ENSG00000188130.9 | 9.361e-11 | 0 | 6716 | gtex_brain_ba24 |
RS6010220 | 22 | 50693554 | MAPK12 | ENSG00000188130.9 | 1.218e-13 | 0 | 6700 | gtex_brain_ba24 |
RS1129880 | 22 | 50694297 | MAPK12 | ENSG00000188130.9 | 6.495e-12 | 0 | 5957 | gtex_brain_ba24 |
rs5771284 | 22 | 50695270 | MAPK12 | ENSG00000188130.9 | 6.474e-12 | 0 | 4984 | gtex_brain_ba24 |
rs5771285 | 22 | 50695908 | MAPK12 | ENSG00000188130.9 | 3.992E-13 | 0 | 4346 | gtex_brain_ba24 |
rs5771111 | 22 | 50695946 | MAPK12 | ENSG00000188130.9 | 5.147E-14 | 0 | 4308 | gtex_brain_ba24 |
rs5771258 | 22 | 50675648 | MAPK12 | ENSG00000188130.9 | 1.396E-6 | 0 | 24606 | gtex_brain_putamen_basal |
RS7290465 | 22 | 50679758 | MAPK12 | ENSG00000188130.9 | 1.908E-6 | 0 | 20496 | gtex_brain_putamen_basal |
RS7292864 | 22 | 50683792 | MAPK12 | ENSG00000188130.9 | 4.098E-7 | 0 | 16462 | gtex_brain_putamen_basal |
RS13058062 | 22 | 50684296 | MAPK12 | ENSG00000188130.9 | 5.641E-8 | 0 | 15958 | gtex_brain_putamen_basal |
RS738334 | 22 | 50688235 | MAPK12 | ENSG00000188130.9 | 3.187E-8 | 0 | 12019 | gtex_brain_putamen_basal |
RS1555048 | 22 | 50688348 | MAPK12 | ENSG00000188130.9 | 3.066e-8 | 0 | 11906 | gtex_brain_putamen_basal |
RS2341111 | 22 | 50690322 | MAPK12 | ENSG00000188130.9 | 1.578E-8 | 0 | 9932 | gtex_brain_putamen_basal |
rs5771276 | 22 | 50692562 | MAPK12 | ENSG00000188130.9 | 1.621E-9 | 0 | 7692 | gtex_brain_putamen_basal |
RS2009816 | 22 | 50692848 | MAPK12 | ENSG00000188130.9 | 2.11E-8 | 0 | 7406 | gtex_brain_putamen_basal |
RS2880034 | 22 | 50692853 | MAPK12 | ENSG00000188130.9 | 1.233E-8 | 0 | 7401 | gtex_brain_putamen_basal |
RS2009815 | 22 | 50692856 | MAPK12 | ENSG00000188130.9 | 3.79E-9 | 0 | 7398 | gtex_brain_putamen_basal |
RS4077315 | 22 | 50692908 | MAPK12 | ENSG00000188130.9 | 2.837E-8 | 0 | 7346 | gtex_brain_putamen_basal |
RS2002766 | 22 | 50692966 | MAPK12 | ENSG00000188130.9 | 2.04e-9 | 0 | 7288 | gtex_brain_putamen_basal |
rs5771280 | 22 | 50693340 | MAPK12 | ENSG00000188130.9 | 4.67E-9 | 0 | 6914 | gtex_brain_putamen_basal |
rs5771281 | 22 | 50693479 | MAPK12 | ENSG00000188130.9 | 4.655e-9 | 0 | 6775 | gtex_brain_putamen_basal |
RS6010218 | 22 | 50693534 | MAPK12 | ENSG00000188130.9 | 1.384E-8 | 0 | 6720 | gtex_brain_putamen_basal |
RS6010219 | 22 | 50693538 | MAPK12 | ENSG00000188130.9 | 1.219E-9 | 0 | 6716 | gtex_brain_putamen_basal |
RS6010220 | 22 | 50693554 | MAPK12 | ENSG00000188130.9 | 5.11E-9 | 0 | 6700 | gtex_brain_putamen_basal |
RS1129880 | 22 | 50694297 | MAPK12 | ENSG00000188130.9 | 1.225E-8 | 0 | 5957 | gtex_brain_putamen_basal |
rs5771284 | 22 | 50695270 | MAPK12 | ENSG00000188130.9 | 9.217E-9 | 0 | 4984 | gtex_brain_putamen_basal |
rs5771285 | 22 | 50695908 | MAPK12 | ENSG00000188130.9 | 5.183E-9 | 0 | 4346 | gtex_brain_putamen_basal |
rs5771111 | 22 | 50695946 | MAPK12 | ENSG00000188130.9 | 4.597E-9 | 0 | 4308 | gtex_brain_putamen_basal |
第二节。转录组注释
一般基因表达(GTEX)
![无法使用](http://www.tjghsg.com/bioinfo/SZGR/GeneImg/MAPK12_DE_GTEx.png)
Devlopment期间的基因表达(BrainCloud)
Footnote:
总共绘制了269个时间点,n = 38个胎儿样品(x = 1:38)。每个三角形代表一个时间点。
时间变化的基因表达(brainspan)
Footnote:
SC:亚皮质区域;SM:感觉运动区域;FC:额叶皮层;和TP:颞顶皮层
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。
大脑区域的顶级共表达基因
前10个积极共表达的基因 | ||
基因 | 皮尔逊的相关性 | 斯皮尔曼的相关性 |
Rev3l | 0.86 | 0.91 |
RHOBTB1 | 0.83 | 0.84 |
HMGCS1 | 0.82 | 0.88 |
NFE2L3 | 0.81 | 0.88 |
L3MBTL3 | 0.81 | 0.90 |
SCN3A | 0.81 | 0.91 |
KIAA0895 | 0.81 | 0.88 |
disp1 | 0.80 | 0.85 |
FAM161A | 0.80 | 0.87 |
ZBTB8B | 0.79 | 0.87 |
前10个负共表达基因 | ||
基因 | 皮尔逊的相关性 | 斯皮尔曼的相关性 |
HLA-F | -0.59 | -0.76 |
REEP6 | -0.57 | -0.56 |
AIFM3 | -0.56 | -0.72 |
CA4 | -0.56 | -0.73 |
TSC22D4 | -0.56 | -0.75 |
aldoc | -0.56 | -0.68 |
AF347015.31 | -0.55 | -0.80 |
FBXO2 | -0.55 | -0.61 |
S100B | -0.55 | -0.75 |
AF347015.27 | -0.55 | -0.78 |