Gene Page:SLC22A23

概括?
基因 63027
Symbol SLC22A23
Synonyms C6orf85
Description solute carrier family 22 member 23
Reference MIM:611697|HGNC:HGNC:21106|Ensembl:ENSG00000137266|HPRD:12904|Vega：Otthumg0000000014144
Gene type protein-coding
Map location 6p25.2
Pascal p-value 0.086
Sherlock p-value 0.434
Fetal beta 1.435
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。
CV:PGCnp Genome-wide Association Study GWAS
DNM：Guipponi_2014 Whole Exome Sequencing analysis 49 DNMs were identified by comparing the exome of 53 individuals with sporadic SCZ and of their non-affected parents
PMID:cooccur High-throughput literature-search 系统的搜索in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type 筛 CG46 Trait Study
SLC22A23 T G NM_015482 p.L245R missense 0 1 Schizophrenia DNM：Guipponi_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2985953 chr13 46056950 SLC22A23 63027 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005215 transporter activity IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0006811 ion transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
去：0016020 membrane IEA -
GO：0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 该途径中的所有SZGR 2.0基因
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 该途径中的所有SZGR 2.0基因
HOOI ST7 TARGETS DN 123 78 该途径中的所有SZGR 2.0基因
CORRE MULTIPLE MYELOMA UP 74 45 该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 该途径中的所有SZGR 2.0基因
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 该途径中的所有SZGR 2.0基因
MARKEY RB1 CHRONIC LOF DN 118 78 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
PATIL LIVER CANCER 747 453 该途径中的所有SZGR 2.0基因
LE EGR2 TARGETS UP 108 75 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS MATURE CELL 293 160 该途径中的所有SZGR 2.0基因
RODWELL AGING KIDNEY NO BLOOD DN 150 93 该途径中的所有SZGR 2.0基因
MARIADASON REGULATED BY HISTONE ACETYLATION UP 83 49 该途径中的所有SZGR 2.0基因
RODWELL AGING KIDNEY DN 145 88 该途径中的所有SZGR 2.0基因
XU GH1 AUTOCRINE TARGETS DN 142 94 该途径中的所有SZGR 2.0基因
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 该途径中的所有SZGR 2.0基因
STEARMAN LUNG CANCER EARLY VS LATE UP 125 89 该途径中的所有SZGR 2.0基因
IZADPANAH STEM CELL ADIPOSE VS BONE DN 108 68 该途径中的所有SZGR 2.0基因
ZHANG TLX TARGETS 36HR UP 221 150 该途径中的所有SZGR 2.0基因
ZHANG TLX TARGETS 60HR UP 293 203 该途径中的所有SZGR 2.0基因
ZHANG TLX TARGETS UP 108 78 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 该途径中的所有SZGR 2.0基因
CHYLA CBFA2T3 TARGETS DN 242 146 该途径中的所有SZGR 2.0基因
WIERENGA STAT5A TARGETS DN 213 127 该途径中的所有SZGR 2.0基因
PILON KLF1 TARGETS UP 504 321 该途径中的所有SZGR 2.0基因
BHAT ESR1 TARGETS NOT VIA AKT1 DN 88 61 该途径中的所有SZGR 2.0基因
BHAT ESR1 TARGETS VIA AKT1 DN 82 51 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 该途径中的所有SZGR 2.0基因
EWSR1 ETS融合DN的Miyagawa目标 229 135 该途径中的所有SZGR 2.0基因
FEVR CTNNB1 TARGETS UP 682 433 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-142-5p 261 267 m8 hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d 259 266 1A,m8 hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-183 3220 3227 1A,m8 hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-218 3468 3474 1A hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-26 650 656 m8 hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ uucaaguaauucaggauagguu
miR-329 3359 3365 m8 hsa-miR-329brain AACACACCUGGUUAACCUCUUU
mir-493-5p 3563 3569 m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-93.hd/291-3p/294/295/302/372/373/520 258 264 m8 hsa-miR-93brain AAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c UAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e AAAGUGCUUCCUUUUUGAGGG
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU