Gene Page:SCNN1G

Summary?
GeneID 6340
Symbol SCNN1G
Synonyms BESC3|ENaCg|ENaCgamma|PHA1|SCNEG
Description sodium channel epithelial 1 gamma subunit
Reference MIM:600761|HGNC:HGNC:10602|Ensembl:ENSG00000166828|HPRD:02862|Vega:OTTHUMG00000131609
Gene type protein-coding
Map location 16p12
Pascal p-value 0.046
eGene Cerebellar Hemisphere
Cerebellum

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01775

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FMNL1 0.92 0.89
RASGRF1 0.89 0.83
CTSB 0.89 0.85
PTPRN 0.89 0.85
GRIN1 0.88 0.82
TMEM38A 0.88 0.93
CNNM1 0.88 0.76
ADAMTS8 0.88 0.89
PRRT3 0.88 0.89
TMEM132D 0.87 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TUBB2B -0.47 -0.58
KIAA1949 -0.47 -0.47
TRAF4 -0.46 -0.60
RPL23A -0.46 -0.63
RBMX2 -0.46 -0.66
FADS2 -0.46 -0.49
CARHSP1 -0.46 -0.63
BCL7C -0.45 -0.60
DYNLT1 -0.45 -0.65
GPR125 -0.45 -0.46

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 11244092
GO:0005216 ion channel activity IEA -
GO:0015280 amiloride-sensitive sodium channel activity TAS 8640238
GO:0031402 sodium ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007588 excretion TAS 8640238
GO:0006814 sodium ion transport TAS 8521520
GO:0006811 ion transport IEA -
GO:0050896 response to stimulus IEA -
GO:0050909 sensory perception of taste IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 8640238
GO:0016324 apical plasma membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TASTE TRANSDUCTION 52 28 All SZGR 2.0 genes in this pathway
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION 42 29 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244 153 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291 176 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS UP 77 62 All SZGR 2.0 genes in this pathway
BALLIF DEVELOPMENTAL DISABILITY P16 P12 DELETION 13 8 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K27ME3 79 59 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 All SZGR 2.0 genes in this pathway