Gene Page:CCL7

Summary?
GeneID 6354
Symbol CCL7
Synonyms FIC|MARC|MCP-3|MCP3|NC28|SCYA6|SCYA7
Description C-C motif chemokine ligand 7
Reference MIM:158106|HGNC:HGNC:10634|Ensembl:ENSG00000108688|HPRD:01150|Vega:OTTHUMG00000132889
Gene type protein-coding
Map location 17q11.2-q12
Pascal p-value 0.649
Sherlock p-value 6.858E-5
Fetal beta 0.539
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search 系统ematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.2039

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL类型
rs606565 chr8 90615792 CCL7 6354 0.13 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NDUFA9 0.92 0.91
TMEM111 0.90 0.90
APOA1BP 0.89 0.85
UQCRFSL1 0.88 0.89
COX5A 0.88 0.84
UROD 0.88 0.83
OAZ1 0.87 0.88
MGST3 0.87 0.87
COX4I1 0.87 0.85
MRPS33 0.87 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC005921.3 -0.49 -0.66
AC010300.1 -0.48 -0.59
EIF5B -0.47 -0.54
SFRS18 -0.45 -0.60
IL3RA -0.44 -0.63
ANKRD36B -0.43 -0.59
BAT2D1 -0.43 -0.35
ZNF814 -0.43 -0.54
PRX -0.43 -0.44
SMTN -0.42 -0.52

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0008201 heparin binding IEA -
GO:0008009 chemokine activity IEA -
GO:0008009 chemokine activity TAS 10770925
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007267 cell-cell signaling TAS 7916328
GO:0007165 signal transduction TAS 10201901|10770925
GO:0006955 immune response IEA -
GO:0006954 inflammatory response IEA -
GO:0006935 chemotaxis TAS 9780207
GO:0006874 cellular calcium ion homeostasis TAS 10770925
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -
GO:0005615 extracellular space IEA -
GO:0005615 extracellular space TAS 7916328

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 62 47 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188 108 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES 57 27 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 175 82 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D DN 31 19 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 142 90 All SZGR 2.0 genes in this pathway
唐克斯的目标OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157 104 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215 137 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211 136 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A UP 191 128 All SZGR 2.0 genes in this pathway
BERENJENO通过RHOA转换 536 340 All SZGR 2.0 genes in this pathway
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP DN 35 20 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203 134 All SZGR 2.0 genes in this pathway
HOWLIN PUBERTAL MAMMARY GLAND 69 40 All SZGR 2.0 genes in this pathway
MANTOVANI NFKB TARGETS UP 43 33 All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING UP 86 54 All SZGR 2.0 genes in this pathway
WOTTON RUNX TARGETS UP 21 14 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP 69 55 All SZGR 2.0 genes in this pathway
LEI HOXC8目标了 12 12 All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK 88 62 All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 83 56 All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN 234 137 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 6HR 59 38 All SZGR 2.0 genes in this pathway
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP 18 11 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO CANTHARIDIN UP 19 12 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 108 71 All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN 64 44 All SZGR 2.0 genes in this pathway
CHEN ETV5 TARGETS SERTOLI 20 10 All SZGR 2.0 genes in this pathway
SARTIPY NORMAL AT INSULIN RESISTANCE UP 34 27 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 9 92 59 All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESISTANCE 20 14 All SZGR 2.0 genes in this pathway
YAMASHITA METHYLATED IN PROSTATE CANCER 57 29 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS 73 55 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP 111 70 All SZGR 2.0 genes in this pathway
SOUCEK MYC TARGETS 8 6 All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP 77 56 All SZGR 2.0 genes in this pathway
RAY ALZHEIMERS DISEASE 13 7 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 107 67 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K4ME3 128 68 All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS 44 30 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
ONGUSAHA BRCA1 TARGETS DN 14 9 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 88 59 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 114 62 All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE DN 99 74 All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297 194 All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-23 127 134 1A,m8 hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-323 126 133 1A,m8 hsa-miR-323brain GCACAUUACACGGUCGACCUCU