Gene Page:年代DHA

年代ummary?
GeneID 6389
年代ymbol 年代DHA
年代ynonyms CMD1GG|FP|PGL5|SDH1|SDH2|SDHF
Description succinate dehydrogenase complex flavoprotein subunit A
Reference MIM:600857|HGNC:HGNC:10680|Ensembl:ENSG00000073578|HPRD:02914|Vega:OTTHUMG00000090275
Gene type protein-coding
Map location 5p15
Pascal p-value 0.296
年代herlock p-value 0.04
Fetal beta -0.732

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 年代ystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

年代ection I. Genetics and epigenetics annotation


年代ection II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
FOLR1 0.69 0.26
RBM47 0.66 0.29
CLDN3 0.65 0.30
CLIC6 0.65 0.27
CP 0.65 0.22
PRLR 0.64 0.45
KCNJ13 0.63 0.09
F5 0.63 0.24
COL8A2 0.63 0.45
C1QTNF5 0.62 0.18
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
AF347015.21 -0.22 -0.22
AP000679.1 -0.21 -0.23
CHRDL1 -0.20 -0.14
AF347015.2 -0.20 -0.22
PLAC9 -0.20 -0.20
年代OX5 -0.20 0.09
AF347015.31 -0.19 -0.21
RLBP1 -0.19 -0.19
ANP32C -0.19 -0.28
CLEC2B -0.19 -0.20

年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CITRATE CYCLE TCA CYCLE 32 23 All SZGR 2.0 genes in this pathway
KEGG OXIDATIVE PHOSPHORYLATION 135 73 All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169 110 All SZGR 2.0 genes in this pathway
KEGG PARKINSONS DISEASE 133 78 All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185 109 All SZGR 2.0 genes in this pathway
BIOCARTA ETC PATHWAY 12 7 All SZGR 2.0 genes in this pathway
BIOCARTA KREB PATHWAY 8 8 All SZGR 2.0 genes in this pathway
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 48 32 All SZGR 2.0 genes in this pathway
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 141 85 All SZGR 2.0 genes in this pathway
REACTOME CITRIC ACID CYCLE TCA CYCLE 26 16 All SZGR 2.0 genes in this pathway
REACTOME RESPIRATORY ELECTRON TRANSPORT 79 44 All SZGR 2.0 genes in this pathway
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 98 56 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178 108 All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 4NM DN 7 6 All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214 139 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 5P15 AMPLICON 26 15 All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS DN 52 34 All SZGR 2.0 genes in this pathway
MOOTHA VOXPHOS 87 51 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 87 57 All SZGR 2.0 genes in this pathway
年代ESTO RESPONSE TO UV C8 72 56 All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS POSTNATAL 63 50 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261 183 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165 106 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163 113 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS DN 142 94 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189 112 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 473 224 All SZGR 2.0 genes in this pathway
年代TEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA 51 35 All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 UP 111 69 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
MOOTHA TCA 16 13 All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447 277 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298 174 All SZGR 2.0 genes in this pathway
年代TEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
金所有障碍少突细胞数量。柯尔 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway