Gene Page:BLK

Summary?
GeneID 640
Symbol BLK
Synonyms MODY11
Description BLK proto-oncogene, Src family tyrosine kinase
Reference MIM:191305|HGNC:HGNC:1057|Ensembl:ENSG00000136573|HPRD:01866|Vega:OTTHUMG00000090729
Gene type protein-coding
Map location 8p23-p22
Pascal p-value 1.997E-4
Fetal beta 0.114
DMG 2 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg22826986 8 11351507 BLK 3.256的军医 -0.735 0.04 DMG:Wockner_2014
cg03860768 8 11351571 BLK 2.71E-6 -7.301 DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某羊乳酪l (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BCAS2 DAM1 breast carcinoma amplified sequence 2 - HPRD 12406557
BCL2 Bcl-2 B-cell CLL/lymphoma 2 - HPRD,BioGRID 9525867
BCL2L1 BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xS BCL2-like 1 Reconstituted Complex BioGRID 9525867
BCR ALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHL breakpoint cluster region - HPRD 8756631
CBL C-CBL | CBL2 | RNF55 Cas-Br-M (murine) ecotropic retroviral transforming sequence - HPRD 8083187
CD79A IGA | MB-1 CD79a molecule, immunoglobulin-associated alpha - HPRD,BioGRID 7592958
CD79B B29 | IGB CD79b molecule, immunoglobulin-associated beta - HPRD,BioGRID 7592958
CTR9 KIAA0155 | SH2BP1 | TSBP | p150 | p150TSP Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) - HPRD 8636124
FCGR2A CD32 | CD32A | CDw32 | FCG2 | FCGR2 | FCGR2A1 | FcGR | IGFR2 | MGC23887 | MGC30032 Fc fragment of IgG, low affinity IIa, receptor (CD32) - HPRD 8756631
PLCG2 - phospholipase C, gamma 2 (phosphatidylinositol-specific) - HPRD,BioGRID 8395016
UBE3A ANCR | AS | E6-AP | EPVE6AP | FLJ26981 | HPVE6A ubiquitin protein ligase E3A - HPRD,BioGRID 10449731


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID GLYPICAN 1PATHWAY 27 20 All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY 52 40 All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY 31 25 All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 57 43 All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 102 78 All SZGR 2.0 genes in this pathway
PID PI3KCI PATHWAY 49 40 All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY 41 32 All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY 34 29 All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129 103 All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY 30 25 All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY 33 25 All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS 29 24 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 126 90 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230 156 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE DN 77 49 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION UP 38 25 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE DN 38 25 All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP 50 35 All SZGR 2.0 genes in this pathway
YU MYC TARGETS DN 55 38 All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293 193 All SZGR 2.0 genes in this pathway
GREENBAUM E2A TARGETS DN 21 11 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR DN 56 37 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN 148 102 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
EHRLICH ICF SYNDROM DN 15 13 All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK 75 47 All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161 105 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN 42 29 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222 147 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 All SZGR 2.0 genes in this pathway