Gene Page:ACOT6

Summary?
GeneID 641372
Symbol ACOT6
Synonyms C14orf42|c14_5530
Description acyl-CoA thioesterase 6
Reference MIM:614267|HGNC:HGNC:33159|Ensembl:ENSG00000205669|Vega:OTTHUMG00000171609
Gene type protein-coding
Map location 14q24.3
Pascal p-value 0.226
eGene Anterior cingulate cortex BA24
Caudate basal ganglia
Cortex
Frontal Cortex BA9
Nucleus accumbens basal ganglia
Putamen basal ganglia
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Xu_2012 Whole Exome Sequencing analysis 新创基因突变4 were identified by exome sequencing of 795 samples in this study

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
ACOT6 chr14 74086428 A G NM_001037162 p.170Y>C missense Schizophrenia DNM:Xu_2012

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10150828 14 74077485 ACOT6 ENSG00000205669.2 1.423E-6 0.01 -164 gtex_brain_ba24
rs12587206 14 74079486 ACOT6 ENSG00000205669.2 1.164E-6 0.01 1837 gtex_brain_ba24
rs11620812 14 74081365 ACOT6 ENSG00000205669.2 1.057E-6 0.01 3716 gtex_brain_ba24
rs10136341 14 74083456 ACOT6 ENSG00000205669.2 1.08E-6 0.01 5807 gtex_brain_ba24
rs5809620 14 74084619 ACOT6 ENSG00000205669.2 4.887E-7 0.01 6970 gtex_brain_ba24
rs58429599 14 74085327 ACOT6 ENSG00000205669.2 1.08E-6 0.01 7678 gtex_brain_ba24
rs7156422 14 74087563 ACOT6 ENSG00000205669.2 1.084E-6 0.01 9914 gtex_brain_ba24
rs12436753 14 74087919 ACOT6 ENSG00000205669.2 1.112E-6 0.01 10270 gtex_brain_ba24
rs7202 14 73742281 ACOT6 ENSG00000205669.2 6.042E-7 0 -335368 gtex_brain_putamen_basal
rs10137126 14 74025873 ACOT6 ENSG00000205669.2 4.067E-7 0 -51776 gtex_brain_putamen_basal
rs201125749 14 74043640 ACOT6 ENSG00000205669.2 5.843E-7 0 -34009 gtex_brain_putamen_basal
rs56013842 14 74043641 ACOT6 ENSG00000205669.2 3.541E-7 0 -34008 gtex_brain_putamen_basal
rs11620997 14 74044260 ACOT6 ENSG00000205669.2 3.281E-7 0 -33389 gtex_brain_putamen_basal
rs10144816 14 74045907 ACOT6 ENSG00000205669.2 3.872E-7 0 -31742 gtex_brain_putamen_basal
rs28410246 14 74046219 ACOT6 ENSG00000205669.2 1.598E-7 0 -31430 gtex_brain_putamen_basal
rs11159027 14 74047516 ACOT6 ENSG00000205669.2 2.85E-7 0 -30133 gtex_brain_putamen_basal
rs10143135 14 74049986 ACOT6 ENSG00000205669.2 3.375E-7 0 -27663 gtex_brain_putamen_basal
rs3742819 14 74058832 ACOT6 ENSG00000205669.2 8.79E-7 0 -18817 gtex_brain_putamen_basal
rs2009883 14 74061457 ACOT6 ENSG00000205669.2 4.163E-8 0 -16192 gtex_brain_putamen_basal
rs11624125 14 74064707 ACOT6 ENSG00000205669.2 4.799E-8 0 -12942 gtex_brain_putamen_basal
rs10138579 14 74068301 ACOT6 ENSG00000205669.2 4.108E-8 0 -9348 gtex_brain_putamen_basal
rs199680410 14 74069787 ACOT6 ENSG00000205669.2 1.661E-9 0 -7862 gtex_brain_putamen_basal
rs12590899 14 74070844 ACOT6 ENSG00000205669.2 4.108E-8 0 -6805 gtex_brain_putamen_basal
rs11159029 14 74071251 ACOT6 ENSG00000205669.2 6.376E-9 0 -6398 gtex_brain_putamen_basal
rs10137762 14 74073461 ACOT6 ENSG00000205669.2 4.109E-8 0 -4188 gtex_brain_putamen_basal
rs7156378 14 74073516 ACOT6 ENSG00000205669.2 4.109E-8 0 -4133 gtex_brain_putamen_basal
rs12323653 14 74074391 ACOT6 ENSG00000205669.2 4.072E-8 0 -3258 gtex_brain_putamen_basal
rs10141401 14 74074804 ACOT6 ENSG00000205669.2 2.777E-9 0 -2845 gtex_brain_putamen_basal
rs12590145 14 74076794 ACOT6 ENSG00000205669.2 2.479E-8 0 -855 gtex_brain_putamen_basal
rs10150828 14 74077485 ACOT6 ENSG00000205669.2 1.348E-8 0 -164 gtex_brain_putamen_basal
rs12587206 14 74079486 ACOT6 ENSG00000205669.2 3.606E-9 0 1837 gtex_brain_putamen_basal
rs11620812 14 74081365 ACOT6 ENSG00000205669.2 3.728E-9 0 3716 gtex_brain_putamen_basal
rs10136341 14 74083456 ACOT6 ENSG00000205669.2 3.775E-9 0 5807 gtex_brain_putamen_basal
rs12891009 14 74083846 ACOT6 ENSG00000205669.2 2.479E-8 0 6197 gtex_brain_putamen_basal
rs5809620 14 74084619 ACOT6 ENSG00000205669.2 4.108E-9 0 6970 gtex_brain_putamen_basal
rs58429599 14 74085327 ACOT6 ENSG00000205669.2 3.775E-9 0 7678 gtex_brain_putamen_basal
rs11626046 14 74085707 ACOT6 ENSG00000205669.2 4.072E-8 0 8058 gtex_brain_putamen_basal
rs7156422 14 74087563 ACOT6 ENSG00000205669.2 3.741E-9 0 9914 gtex_brain_putamen_basal
rs12436753 14 74087919 ACOT6 ENSG00000205669.2 3.705E-9 0 10270 gtex_brain_putamen_basal
rs12878358 14 74088234 ACOT6 ENSG00000205669.2 2.293E-8 0 10585 gtex_brain_putamen_basal
rs10134911 14 74095256 ACOT6 ENSG00000205669.2 1.533E-7 0 17607 gtex_brain_putamen_basal
rs4899474 14 74096603 ACOT6 ENSG00000205669.2 6.633E-7 0 18954 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS UP 77 62 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
BERNARD PPAPDC1B TARGETS DN 58 39 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242 146 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway